Establishing a Flow Process to Coumarin-8-Carbaldehydes as Important Synthetic Scaffolds
作者:Jaroslav Zak、David Ron、Elena Riva、Heather P. Harding、Benedict C. S. Cross、Ian R. Baxendale
DOI:10.1002/chem.201201039
日期:2012.8.6
Despite their usefulness as fluorophores and synthetic precursors, efficient and reliable routes to coumarin‐8‐carbaldehydes are lacking. We describe here a high‐yielding continuous flow synthesis that requires no manual intermediate purification or work‐up, giving access to multigram quantities of the aldehyde product.