3,4,5-triacetoxy-6-(4-methyl-2-oxo-2H-chromen-7-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester | 929549-08-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3,4,5-triacetoxy-6-(4-methyl-2-oxo-2H-chromen-7-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
• CAS: 929549-08-6
• 化学式: C₂₃H₂₄O₁₂
• 分子量: 492.436
• InChiKey: TXEVHMZINNBIAP-DLBZZEGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.17
• 重原子数：
  35.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  153.87
• 氢给体数：
  0.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  3,4,5-triacetoxy-6-(4-methyl-2-oxo-2H-chromen-7-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 在 甲醇 、 sodium methylate 作用下， 反应 1.0h， 生成
  参考文献：
  名称：

  Profiling of Glycosidase Activities Using Coumarin-Conjugated Glycoside Cocktails

  摘要：

  Glycosidases are a large subgroup of carbohydrate-processing enzymes that hydrolytically cleave the glycosidic bond. Glycans formed by the action of glycosidases are involved in various biological processes. Genetic abnormalities in glycosidases are associated with inherited diseases. Thus, characterization of the catalytic activities of glycosidases is of great importance. Herein, we describe a simple and rapid approach for determining glycosidase activity profiles using coumarin-conjugated glycoside cocktails.

  DOI：

  10.1021/ol062889f
• 作为产物：
  描述：

  sodium 4-methylumbelliferonate 、 methyl (2,3,4-tri-O-acetyl-α-D-galactopyranosyl bromide)uronate 在 sodium hydroxide 、 苄基三乙基氯化铵 作用下， 以 氯仿 为溶剂， 反应 5.0h， 以71%的产率得到3,4,5-triacetoxy-6-(4-methyl-2-oxo-2H-chromen-7-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Profiling of Glycosidase Activities Using Coumarin-Conjugated Glycoside Cocktails

  摘要：

  Glycosidases are a large subgroup of carbohydrate-processing enzymes that hydrolytically cleave the glycosidic bond. Glycans formed by the action of glycosidases are involved in various biological processes. Genetic abnormalities in glycosidases are associated with inherited diseases. Thus, characterization of the catalytic activities of glycosidases is of great importance. Herein, we describe a simple and rapid approach for determining glycosidase activity profiles using coumarin-conjugated glycoside cocktails.

  DOI：

  10.1021/ol062889f