1-[3-(4-iodophenoxy)propyl]pyrrolidine | 415934-29-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[3-(4-iodophenoxy)propyl]pyrrolidine
• CAS: 415934-29-1
• 化学式: C₁₃H₁₈INO
• 分子量: 331.197
• InChiKey: PUTMAMYIBZIZPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-tert-butyldimethylsilyloxyethyl)-1H-indole 、 1-[3-(4-iodophenoxy)propyl]pyrrolidine 在 copper(l) iodide 、 N,N'-二甲基乙二胺 potassium phosphate 作用下， 以 甲苯 为溶剂， 生成 2-[2-(tert-butyldimethylsilanyloxy)ethyl]-1-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1H-indole
  参考文献：
  名称：

  WO2007/47775

  摘要：

  公开号：
• 作为产物：
  描述：

  1-(3-氯丙基)吡咯烷 、 4-碘苯酚 在 sodium hydride 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以90%的产率得到1-[3-(4-iodophenoxy)propyl]pyrrolidine
  参考文献：
  名称：

  WO2007/47775

  摘要：

  公开号：

文献信息

• Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders
  申请人：Bennani Youssef L.

  公开号：US20090036446A1

  公开（公告）日：2009-02-05

  This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain indole derivatives and their salts and solvates. These compounds have H 3 histamine receptor antagonist activity. This invention also relates to pharmaceutical compositions containing these compounds and to a method of treating disorders in which histamine H 3 receptor blockade is beneficial.

  本发明涉及具有药理活性的化合物、含有这些化合物的组合物以及使用这些化合物和组合物的治疗方法。更具体地说，本发明涉及某些吲哚衍生物及其盐和溶剂化物。这些化合物具有H3组胺受体拮抗活性。本发明还涉及含有这些化合物的药物组合物以及一种治疗组胺H3受体阻滞有益的疾病的方法。
• INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS
  申请人：Bennani Youssef L.

  公开号：US20110059966A1

  公开（公告）日：2011-03-10

  This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain indole derivatives and their salts and solvates. These compounds have H 3 histamine receptor antagonist activity. This invention also relates to pharmaceutical compositions containing these compounds and to a method of treating disorders in which histamine H 3 receptor blockade is beneficial.

  本发明涉及具有药理活性的化合物，含有这些化合物的组合物，以及使用这些化合物和组合物的治疗方法。更具体地，本发明涉及某些吲哚衍生物及其盐和溶剂。这些化合物具有H3组胺受体拮抗活性。本发明还涉及含有这些化合物的制药组合物以及一种治疗组胺H3受体阻断有益的疾病的方法。
• Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives
  作者：Stephan A. Ohnmacht、Marialuisa Micco、Vanessa Petrucci、Alan K. Todd、Anthony P. Reszka、Mekala Gunaratnam、Marta A. Carvalho、Mire Zloh、Stephen Neidle

  DOI：10.1016/j.bmcl.2012.07.065

  日期：2012.9

  The HSP90 protein is an important target in cancer. We report here that stable quadruplex DNAs can be formed from a promoter sequence in the HSP90 gene, on the basis of melting, circular and NMR studies, and show that these can be selectively targeted by non-macrocyclic quadruplex-stabilizing phenyl bis-oxazole derivatives. These do not bind significantly to duplex DNA and show low stabilization of the human telomeric quadruplex. These results suggest an approach to targeting HSP90 at the DNA level. (C) 2012 Elsevier Ltd. All rights reserved.
• TETRACYCLIC CARBOLINE DERATIVES FOR INHIBITING ANGIOGENESIS
  申请人：PTC Therapeutics, Inc.

  公开号：EP1732543B1

  公开（公告）日：2017-05-10
• US7528262B2
  申请人：——

  公开号：US7528262B2

  公开（公告）日：2009-05-05