Alkyl hydrogen α-(benzyloxycarbonylamino)benzylphosphonates are prepared from substituted benzaldehydes, benzyl carbamate, and phosphorus(III) chloride in acetic acid containing thionyl chloride and subsequent alcoholysis. The reactions proceed smoothly at room temperature and afford the title compounds in moderate to good yield.
烷基氢α-(苄氧羧
氨基)苄基
膦酸酯是由取代的
苯甲醛、苄基
氨基甲酸酯和
氯化
磷(III)在含有
氯化亚
硫酰的
醋酸中合成的,随后进行醇解。反应在室温下顺利进行,能够以中等到良好的收率得到目标化合物。