tert-butyl cyclohexyl(4-methoxybenzyl)carbamate | 1396518-01-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: tert-butyl cyclohexyl(4-methoxybenzyl)carbamate
• CAS: 1396518-01-6
• 化学式: C₁₉H₂₉NO₃
• 分子量: 319.444
• InChiKey: XISLDTVFLGREBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.77
• 重原子数：
  23.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  38.77
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  N-甲基环己胺 在 四甲基乙二胺 、 仲丁基锂 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 、 环己烷 为溶剂， 反应 36.67h， 生成 tert-butyl cyclohexyl(4-methoxybenzyl)carbamate
  参考文献：
  名称：

  Ligand-Controlled α- and β-Arylation of Acyclic N-Boc Amines

  摘要：

  AbstractThe palladium‐catalyzed ligand‐controlled arylation of α‐zincated acyclic amines, obtained by directed α‐lithiation and transmetalation, is described. Whereas PtBu3 gave rise to α‐arylated Boc‐protected amines, more flexible N‐phenylazole‐based phosphine ligands induced major β‐arylation through migrative cross‐coupling.

  DOI：

  10.1002/anie.201310904

文献信息

• Potassium Boc-Protected Secondary Aminomethyltrifluoroborates: Synthesis and Suzuki–Miyaura Cross-Coupling Reactions
  作者：Gary A. Molander、Inji Shin

  DOI：10.1021/ol301955s

  日期：2012.9.7

  Seven potassium Boc-protected secondary aminomethyltrifluoroborates were prepared in a standardized two-step process. The Suzuki-Miyaura cross-coupling reaction was studied with this new class of nucleophiles, and a large variety of aryl and hetaryl chlorides provided the desired products in good to excellent yields, thereby allowing easy access to secondary aminomethyl substructures.