2-(4-ethyl-thiazol-5-yl)-ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-ethyl-thiazol-5-yl)-ethanol
• 英文别名: 4-Aethyl-5-<2-hydroxy-aethyl>-thiazol；5-Thiazoleethanol, 4-ethyl-；2-(4-ethyl-1,3-thiazol-5-yl)ethanol
• 化学式: C₇H₁₁NOS
• 分子量: 157.236
• InChiKey: SBNDHNYUQZYQSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  61.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-ethyl-thiazol-5-yl)-ethanol 、 alkaline earth salt of/the/ methylsulfuric acid 生成 3-<4-Amino-2-methyl-pyrimidinyl-(5)-methyl>-4-aethyl-5-<2-hydroxy-aethyl>-thiazolium Bromid-hydrobromid
  参考文献：
  名称：

  US2386766

  摘要：

  公开号：
• 作为产物：
  描述：

  硫代甲酰胺 、 6-acetossi-4-cloro-3-esanone 以 1,4-二氧六环 为溶剂， 反应 0.5h， 生成 2-(4-ethyl-thiazol-5-yl)-ethanol
  参考文献：
  名称：

  Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

  摘要：

  Tumor cells extensively utilize the pentose phosphate pathway for the synthesis of ribose. Transketolase is a key enzyme in this pathway and has been suggested as a target for inhibition in the treatment of cancer. In a pharmacodynamic study, nude mice with xenografted HCT-116 tumors were dosed with 1 ('N3'-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxyethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an analog of thiamine, the co-factor of transketolase. Transketolase activity was almost completely suppressed in blood, spleen, and tumor cells, but there was little effect on the activity of the other thiamine-utilizing enzymes alpha-ketoglutarate dehydrogenase or glucose-6-phosphate dehydrogenase. Synthesis and SAR of transketolase inhibitors is described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.101

文献信息

• 1-Carbacephalosporin antibiotics
  申请人：ELI LILLY AND COMPANY

  公开号：EP0232623A1

  公开（公告）日：1987-08-19

  7β-Acylamino-3-alkoxycarbonyl-(and 3-keto)-1-carba (1-dethia)-3-cephem-4-carboxylic acids and derivatives and related 3-substituted compounds are provided as antibiotics useful for treating infections in man and other animals. Pharmaceutical formulations comprising the antibiotics, intermediates, and a process for their preparation are also provided.

  本发明提供了 7β-乙酰氨基-3-烷氧基羰基-（和 3-酮基）-1-咔巴（1-二硫杂）-3-头孢-4-羧酸及其衍生物和相关的 3-取代化合物，作为抗生素可用于治疗人类和其他动物的感染。此外，还提供了包含这些抗生素、中间体及其制备工艺的药物制剂。
• DE685032
  申请人：——

  公开号：——

  公开（公告）日：——
• US4791106A
  申请人：——

  公开号：US4791106A

  公开（公告）日：1988-12-13
• US4892942A
  申请人：——

  公开号：US4892942A

  公开（公告）日：1990-01-09