ethyl 4,4-diethoxy-2-methyl-3-oxobutanoate | 24132-51-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: ethyl 4,4-diethoxy-2-methyl-3-oxobutanoate
• 英文别名: Ethyl-2-diethoxyacetylpropionat；Ethyl-4,4-diethoxy-2-methyl-oxobutyrat；4,4-diethoxy-2-methyl-acetoacetic acid ethyl ester；4,4-Diaethoxy-2-methyl-acetessigsaeure-aethylester；ethyl α-(diethoxyacetyl)-propionate
• CAS: 24132-51-2
• 化学式: C₁₁H₂₀O₅
• 分子量: 232.277
• InChiKey: IYNJJALHAZEHMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 4,4-diethoxy-2-methyl-3-oxobutanoate 在 2,6-二甲基吡啶 、 calcium hydroxide 、 戴斯-马丁氧化剂 、 三氟乙酸 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 61.0h， 生成
  参考文献：
  名称：

  C-6芳基甲基官能化S-DABO及其相关类似物的通用途径。

  摘要：

  自1992年被发现以来，为了获得更好的非核苷逆转录酶抑制剂（NNRTIs），3,4-二氢-2-烷氧基-6-苄基-4-氧嘧啶（DABO）进行了许多结构修饰艾滋病 在这里，我们报告了一种新颖的C-6芳基甲基官能化的S-DABO的合成的直接途径和通用途径，这是一类开发不多的衍生物。最后，对合成衍生物的生物学评估导致鉴定出有前途的抗HIV-1铅化合物。

  DOI：

  10.1021/ol071225i
• 作为产物：
  描述：

  2,2-二乙氧基乙酸乙酯 在 乙醇 、 sodium 作用下， 生成 ethyl 4,4-diethoxy-2-methyl-3-oxobutanoate
  参考文献：
  名称：

  Density and Water Exchange-Dependent Growth and Survival of Litopenaeus setiferus Postlarvae

  摘要：

  AbstractThis present study was designed to investigate the effects of stocking density and water exchange on the growth rate, survival and performance index of L. setiferus postlarvae under controlled laboratory conditions. The experiment was done with postlarvae (PL10 to PL40) at densities of 50, 150, 250 and 350 shrimp/m2 and various different water exchanges rate per day (0, 6, 12 and 18%). The maximum growth rate was obtained for shrimp with 12% water exchange per day at all densities. A reduction of the maximum growth rate was observed in relation to density with the highest values in shrimp stocked in a density of 50 and 150 shrimp/m2 (mean value of 0.53 mg/d) and the lowest in shrimp stocked in a density of 350 shrimp/m2 (0.24 mg/d). The multiple regression equation obtained to relate performance index (growth rate* survival : PI), shrimp density (X1) and water exchange (X2) was: PI = 0.31 + (0.001) X1+ 0.039 X2+ 2.28 × 10−6 X12+ (−0.0017) X22+ (0.000026)X1X2,R2= 0.78; P > 0.03. According to this equation the optimum shrimp density‐water exchange comhination was between 5 to 12% of water exchange at stocking density of between 50 and 150 shrimp/m2. Salinity, ammonia‐N and nitrite‐N increased according to the time spent in tanks without water exchange. With no (0%) water exchange, water quality parameters measured were outside the optimum for L. setiferus postlarvae. The use of optimum density and water exchange in a nursery system for L. setiferus with optimum variables established is proposed.

  DOI：

  10.1111/j.1749-7345.2001.tb01091.x

文献信息

• 2-Oxopropionaldehyde bis(thiosemicarbazone) derivatives
  申请人：Nihon Medi-Physics Co., Ltd.

  公开号：US04287362A1

  公开（公告）日：1981-09-01

  A radioactive diagnostic agent which comprises a protein and a radioactive metallic element combined with intervention of a bifunctional chelating agent of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group and is characteristic in having high stability even after administered into a human body.

  一种放射性诊断剂，包括蛋白质和与双功能螯合剂的干预结合的放射性金属元素，该螯合剂的结构公式为：##STR1## 其中R.sup.1、R.sup.2、R.sup.3和R.sup.4分别是氢原子或C.sub.1-C.sub.3烷基基团，并具有高稳定性，即使在人体内投入后也能保持稳定。
• Johnson; Cretcher, Journal of Biological Chemistry, 1916, vol. 26, p. 110
  作者：Johnson、Cretcher

  DOI：——

  日期：——
• Vakulova,L.A. et al., Journal of general chemistry of the USSR, 1975, vol. 45, p. 2454 - 2460
  作者：Vakulova,L.A. et al.

  DOI：——

  日期：——
• 2-Oxopropionaldehyde bis(thiosemicarbazone)derivatives and their production and use
  申请人：NIHON MEDI-PHYSICS CO., LTD.

  公开号：EP0024464B1

  公开（公告）日：1982-05-12
• US4287362A
  申请人：——

  公开号：US4287362A

  公开（公告）日：1981-09-01