benzyl methoxymethyl sulfide | 98954-22-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl methoxymethyl sulfide
• 英文别名: Benzylmercapto-dimethylether；benzylsulfanyl-methoxy-methane；Benzylmercapto-methoxy-methan；Methoxymethyl-benzyl-sulfid；Methoxymethylsulfanylmethylbenzene
• CAS: 98954-22-4
• 化学式: C₉H₁₂OS
• 分子量: 168.26
• InChiKey: GPDUJBBYEIRPPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  benzyl methoxymethyl sulfide 在 N-氯代丁二酰亚胺 、 水 作用下， 以 溶剂黄146 为溶剂， 反应 0.83h， 以89%的产率得到苄磺酰氯
  参考文献：
  名称：

  A New and Facile Synthesis of Sulfonyl Chlorides

  摘要：

  苯磺酰氯和苄磺酰氯的合成在出色产率下通过芳基（或苄基）甲氧基甲基硫醚的水相氯化反应完成。功能化硫醚可以从溴苯基甲氧基甲基硫醚轻松制备。

  DOI：

  10.1055/s-1992-26333
• 作为产物：
  描述：

  苄基氯甲基硫醚 在 甲醇 、 氢氟酸 作用下， 生成 benzyl methoxymethyl sulfide
  参考文献：
  名称：

  Petrow; Sokol'skii, Zhurnal Obshchei Khimii, 1957, vol. 27, p. 2711,2713; engl. Ausg. S. 2751, 2753

  摘要：

  DOI：

文献信息

• PROCESS FOR PRODUCING IMIDAZOPYRIDINE DERIVATIVE AND INTERMEDIATE
  申请人：Eisai Co., Ltd.

  公开号：EP0627433A1

  公开（公告）日：1994-12-07

  The invention provides an industrially excellent process for producing a 2-alkyl-3-(biphenyl-4-yl)-methyl-3H-imidazo[4,5-b]pyridine derivative represented by general formula (II), serving as a precursor of the angiotensin II receptor antagonist useful as an antihypertensive, a biphenyl derivative serving as a precursor of the substituent of the imidazopyridine derivative, a process for producing the biphenyl derivative, and an intermediate useful for producing the biphenyl derivative. The imidazopyridine derivative (II) can be produced in a high yield according to the process of the invention by subjecting a 2-amino-5-halogeno-3-nitropyridine derivative to amidation, N-alkylation and reductive cyclization. This process is industrially excellent, because the halogen atom introduced into the 5-position as a protective group in the nitration step can be eliminated simultaneously in the subsequent step. The above biphenyl derivative is excellent in reactivity and product purity, thus being an intermediate suitable for industrial production.

  本发明提供了一种生产通式(II)代表的 2-烷基-3-(联苯-4-基)-甲基-3H-咪唑并[4,5-b]吡啶衍生物的工业化优良工艺，该衍生物可作为血管紧张素 II 受体拮抗剂的前体，用于抗高血压、作为咪唑并吡啶衍生物取代基前体的联苯衍生物，生产联苯衍生物的工艺，以及生产联苯衍生物的中间体。根据本发明的工艺，通过对 2-氨基-5-卤代-3-硝基吡啶衍生物进行酰胺化、N-烷基化和还原环化，可以高产率生产出咪唑吡啶衍生物 (II)。由于在硝化步骤中作为保护基团引入 5 位的卤素原子可以在后续步骤中同时消除，因此该工艺在工业上非常出色。上述联苯衍生物在反应活性和产品纯度方面都非常出色，因此是一种适合工业化生产的中间体。
• Aluminum-26 in H4 chondrites: Implications for its production and its usefulness as a fine-scale chronometer for early solar system events
  作者：Ernst Zinner、Christa Göpel

  DOI：10.1111/j.1945-5100.2002.tb00872.x

  日期：2002.7

  Abstract— In order to investigate whether or not 26Al can be used as a fine‐scale chronometer for early solar system events we measured, with an ion microprobe, Mg isotopes and Al/Mg ratios in separated plagioclase, olivine, and pyroxene crystals from the H4 chondrites Ste Marguerite (SM), Forest Vale (FV), Beaver Creek and Quenggouk and compared the results with the canonical 26Al/27Al ratio for calcium‐aluminum‐rich inclusions (CAIs). For SM and FV, Pb/Pb and Mn‐Cr ages have previously been determined (Göpel et al., 1994; Polnau et al., 2000; Polnau and Lugmair, 2001). Plagioclase grains from these two meteorites show clear excesses of 26Mg. The 26Al/27Al ratios inferred from these excesses and from isotopically normal Mg in pyroxene and olivine are (2.87 ± 0.64) × 10−7 for SM and (1.52 ± 0.52) × 10−7 for FV. The differences between these ratios and the ratio of 5 times 10−5 in CAIs indicate time differences of 5.4 ± 0.1 Ma and 6.1 ± 0.2 Ma for SM and FV, respectively. These differences are in agreement with the absolute Pb/Pb ages for CAIs and SM and FV phosphates but there are large discrepancies between the U‐Pb and Mn‐Cr system for the relative ages for CAIs, SM and FV. For example, Mn‐Cr ages of carbonates from Kaidun are older than the Pb/Pb age of CAIs. However, even if we require that CAIs are older than these carbonates, the time difference between this “adjusted” CAI age and the Mn‐Cr ages of SM and FV require that 26 Al was widely distributed in the early solar system at the time of CAI formation and was not mostly present in CAIs, a feature of the X‐wind model proposed by Shu and collaborators (Gounelle et al., 2001; Shu et al., 2001). From this we conclude that there was enough 26Al to melt small planetary bodies as long as they formed within 2 Ma of CAIs, and that 26Al can serve as a fine‐scale chronometer for early solar system events.
• Sulfinate Esters from Methoxymethyl Sulfides
  作者：Young Kwan Ko、Dong Wan Koo、Jeong Soon Kim、Dae-Whang Kim

  DOI：10.1080/00397919508011835

  日期：1995.9

  Several benzene(or phenylmethane) sulfinate esters were synthesized in 53-98% yields from the corresponding methoxymethyl(MOM) sulfides employing NBS as oxidant.
• US5554757A
  申请人：——

  公开号：US5554757A

  公开（公告）日：1996-09-10
• US5587504A
  申请人：——

  公开号：US5587504A

  公开（公告）日：1996-12-24