N-methyl N-phenyl carbamate d'isopropyle | 3295-92-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl N-phenyl carbamate d'isopropyle
• 英文别名: isopropyl N-methyl-N-phenylcarbamate；N-methyl Probham；Carbanilic acid, N-methyl-, isopropyl ester；propan-2-yl N-methyl-N-phenylcarbamate
• CAS: 3295-92-9
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: OGQJEQNWJVFSGO-UHFFFAOYSA-N

物化性质

• 沸点：
  329.46°C (rough estimate)
• 密度：
  1.0945 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  N-methyl N-phenyl carbamate d'isopropyle 在 Beauveria sulfurescens ATCC 7159 作用下， 反应 96.0h， 生成 (4-羟基苯基)-氨基甲酸异丙酯
  参考文献：
  名称：

  微生物转化：第4（1）部分：真菌球孢白僵菌对芳香环的区域选择性对羟基化反应使异丙基正苯基代谢

  摘要：

  真菌白僵菌已实现了异丙基N-苯基氨基甲酸酯1芳香环的特定对羟基化。氘标记的化合物的研究表明该转化具有很高的保留（NIH位移），这一事实表明所暗示的机理与芳烃氧化物的中间形成是一致的。另外，已经观察到苯酚的葡糖苷共轭物的形成。

  DOI：

  10.1016/0040-4020(86)80008-4
• 作为产物：
  描述：

  2-(甲基(苯基)氨基)乙腈 在 copper(l) iodide 、 氧气 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 12.75h， 生成 N-methyl N-phenyl carbamate d'isopropyle
  参考文献：
  名称：

  2-(N-methylanilino)-2-phenylsulfanylacetonitrile, a reagent tested for electrophilic, nucleophilic and radical reactions

  摘要：

  2-(N-Methylanilino) -2-phenylsulfanylacetonitrile 1 has been readily prepared from 2-(N-methylanilino)acetonitrile and diphenyl disulfide. Alkylation of the anion of 1 with halogenoalkanes resulted in concurrent elimination of benzenethiol to give conjugated alpha-aminoalkenenitriles of 2E-configuration. Autoxidation of 1 in the presence of alkoxide ions afforded alkyl N-methyl-N-phenylcarbamates. Nucleophilic substitution of 1 with Grignard reagent or appropriate silyl compounds were promoted by Cul or Lewis acids to give varied alpha-amino nitriles. The 4-oxo-2-amino nitriles 9 obtained by condensation of 1 and titanium enolates can be considered as derivatives of 1,3-dicarbonyl compounds with the aldehyde group being activated to give an amino nitrile umpolung. When 1 was treated with tributylstannane, the corresponding amino nitrile alpha-radical was formed and the self-coupling product was isolated.

  DOI：

  10.1039/p19940002217

文献信息

• ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY
  申请人：Ghosh Arun K.

  公开号：US20100286145A1

  公开（公告）日：2010-11-11

  The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.

  本发明提供了新型的β-分泌酶抑制剂及其使用方法，包括治疗阿尔茨海默病的方法。
• Nucleotide sequence and method for controlling insect infestation
  申请人：BEIJING DABEINONG BIOTECHNOLOGY CO., LTD.

  公开号：US10676741B2

  公开（公告）日：2020-06-09

  Disclosed are a nucleotide sequence and a method for controlling insect invasions, the isolated polynucleotide sequence comprising: (a) a polynucleotide sequence as shown in SEQ ID NO: 1, 2 or 3; or (b) a polynucleotide sequence hybridizing with the polynucleotide sequence defined in (a) under stringent conditions; or (c) a polynucleotide sequence having an identity of not less than 80% to the polynucleotide sequence defined in (a); or (d) a polynucleotide sequence of at least 19 consecutive nucleotides of the polynucleotide sequence defined in (a), wherein a double-stranded RNA comprising at least one strand complementary to the polynucleotide sequence, when ingested by an insect pest from Hemiptera, inhibits growth of the insect pest; or (e) a complementary sequence of the polynucleotide sequence as defined in (a), (b), (c) or (d). The three target sequences for controlling an insect pest from Hemiptera, Lygus, have the advantages of efficiency, specificity, convenience and low cost.

  公开了一种用于控制昆虫入侵的核苷酸序列和方法，该分离的多核苷酸序列包括：(a) SEQ ID NO：1、2 或 3 中所示的多核苷酸序列；或 (b) 在严格条件下与(a)中定义的多核苷酸序列杂交的多核苷酸序列；或 (c) 与(a)中定义的多核苷酸序列的同一性不低于 80%的多核苷酸序列；或(d)(a)中定义的多核苷酸序列的至少19个连续核苷酸的多核苷酸序列，其中包含至少一条与该多核苷酸序列互补的链的双链RNA，当被半翅目害虫摄食时，可抑制该害虫的生长；或(e)(a)、(b)、(c)或(d)中定义的多核苷酸序列的互补序列。这三种用于控制半翅目害虫蝇蛆的靶序列具有高效、特异、方便和成本低的优点。
• Dembele, Albert; Deshayes, Henri; Pete, Jean-Pierre, Bulletin de la Societe Chimique de France, 1988, # 4, p. 671 - 680
  作者：Dembele, Albert、Deshayes, Henri、Pete, Jean-Pierre

  DOI：——

  日期：——
• CHUANG, TSUNG-HSUN;YANG, CHAU-CHEN;CHANG, CHIH-JUNG;FANG, JIM-MIN, SYNLETT.,(1990) N2, C. 733-734
  作者：CHUANG, TSUNG-HSUN、YANG, CHAU-CHEN、CHANG, CHIH-JUNG、FANG, JIM-MIN

  DOI：——

  日期：——
• VIGNE B.; ARCHELAS A.; FOURNERON J. D.; FURSTOSS R., TETRAHEDRON, 42,(1986) N 9, 2451-2456
  作者：VIGNE B.、 ARCHELAS A.、 FOURNERON J. D.、 FURSTOSS R.

  DOI：——

  日期：——

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