IR-797氯化物

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: IR-797氯化物
• 中文别名: 2-[2-[2-氯-3-[2-(1,3-二氢-1,3,3-三甲基-2H-吲哚-2-亚基)-亚乙基]-1-环戊烯-1-基-乙烯基]-1,3,3-三甲基-3H-吲哚氯化物
• 英文名称: IR-797 chloride
• 英文别名: (2E)-2-[(2Z)-2-[2-chloro-3-[(E)-2-(1,3,3-trimethylindol-1-ium-2-yl)ethenyl]cyclopent-2-en-1-ylidene]ethylidene]-1,3,3-trimethylindole;chloride
• 化学式: C₃₁H₃₄ClN₂*Cl
• 分子量: 505.53
• InChiKey: OATKVFFCVUJOEX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.78
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  6.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  IR-797氯化物 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 30.25h， 生成
  参考文献：
  名称：

  用于近红外光增强细胞毒性和细胞成像的七次甲基花青铂 (II) 络合物

  摘要：

  用近红外光控制产生细胞毒性剂是光激活癌症治疗的当前焦点，包括涉及细胞毒性铂类的治疗。 IR797-Platin 是一种七次甲基花青支架 Pt II复合物，在近红外光下表现出前所未有的 Pt-O 键断裂和 DNA 铂化增强。该复合物还表现出显着的单线态氧量子产率，因此有资格作为近红外光动力治疗剂。该复合物在近红外光下对多种癌细胞系的细胞毒性增强了 30-60 倍。细胞成像特性也被用来观察其在细胞质细胞器中的显着共定位。这是近红外光引发疗法的首次演示，涉及活性顺铂和单线态氧的细胞毒性作用。

  DOI：

  10.1002/anie.201806911

文献信息

• [EN] NEAR-IR ACTIVATABLE FLUORESCENT SMALL MOLECULES WITH DUAL MODES OF CYTOTOXICITY<br/>[FR] PETITES MOLÉCULES FLUORESCENTES ACTIVABLES DANS L'IR PROCHE PRÉSENTANT UN DOUBLE MODE DE CYTOTOXICITÉ
  申请人：UNIV VIRGINIA COMMONWEALTH

  公开号：WO2019217606A1

  公开（公告）日：2019-11-14

  Near-infrared activatable fluorescent small molecules for the photodynamic treatment of cancer are provided. Methods of treatment include contacting a plurality of cells of the cancer with a near-infrared activatable fluorescent small molecule and directing a near-IR light to the molecule for an amount of time sufficient to induce release of the active platinum species and a reactive oxygen species.

  提供了一种用于光动力治疗癌症的近红外可激活荧光小分子。治疗方法包括将多个癌细胞与近红外可激活荧光小分子接触，并将近红外光直接照射于该分子上，以诱导活性铂物种和反应性氧化物种的释放，持续一定时间。
• COMPOSITIONS AND METHODS OF USE FOR DETECTION AND IMAGING OF PRINTS BY SURFACE-ENHANCED SPECTROSCOPIC TECHNIQUES
  申请人：Lewis Linda Anne

  公开号：US20140065290A1

  公开（公告）日：2014-03-06

  The present invention relates to a print detection composition comprising nanoparticles having an aerogel metal oxide core covered by a layer of zerovalent noble metal, and optionally, a fluorescent organic dye, wherein the fluorescent organic dye is within an interacting distance of the plasmon resonance field of the layer of zerovalent noble metal. The invention is also directed to surface-enhanced spectroscopic methods for imaging a latent print, particularly a latent fingerprint, by use of the print detection composition.

  本发明涉及一种印迹检测组合物，包括具有气凝胶金属氧化物核心的纳米颗粒，其表面覆盖有零价贵金属层，以及可选的荧光有机染料，其中荧光有机染料位于零价贵金属层的等离子共振场的相互作用距离内。本发明还涉及利用印迹检测组合物进行表面增强光谱成像的方法，特别是用于成像潜在的印迹，特别是潜在指纹。
• Thermally reactive infrared absorption polymers and their use in a heat sensitive lithographic printing plate
  申请人：Ipagsa Industrial, SL.

  公开号：EP1655317A1

  公开（公告）日：2006-05-10

  The invention provides a near infrared absorption polymer comprising at least two different pendent infra-red chromophoric moieties covalently bonded to the backbone of an alkali-soluble resin, at least one of which is an indole cyanine dye and the other of which is a benz [e]-indole cyanine dye. When used in the coating of a heat sensitive positive working lithographic printing plate precursor the stabilization time needed after manufacture is significantly reduced, avoiding further conditioning processes before use. The precursors are preferably imagewise exposed with a near-infrared laser emitting at between 780 nm and 850 nm.

  本发明提供了一种近红外吸收聚合物，它由至少两个不同的下垂红外发色分子共价键合到碱溶性树脂的骨架上，其中至少一个是吲哚氰染料，另一个是苯[e]-吲哚氰染料。当用于热敏正片工作平版印刷版前驱体的涂层时，生产后所需的稳定时间大大缩短，从而避免了使用前的进一步调节过程。前驱体最好使用波长在 780 纳米到 850 纳米之间的近红外激光进行图像曝光。
• Thermally Reactive Infrared Absorption Polymers and Their Use in a Heat Sensitive Lithographic Printing Plate
  申请人：Bentley Peter Jonathan

  公开号：US20080261151A1

  公开（公告）日：2008-10-23

  The invention provides a near infrared absorption polymer comprising at least two different pendent infra-red chromophoric moieties covalently bonded to the backbone of an alkali-soluble resin, at least one of which is an indole cyanine dye and the other of which is a benz[e]-indole cyanine dye. When used in the coating of a heat sensitive positive working lithographic printing plate precursor the stabilization time needed after manufacture is significantly reduced, avoiding further conditioning processes before use. The precursors are preferably imagewise exposed with a near-infrared laser emitting at between 780 nm and 850 nm.
• US8632947B2
  申请人：——

  公开号：US8632947B2

  公开（公告）日：2014-01-21