α,α,α',α'-Tetramethyl-adipinsaeure-dimethylester | 17219-17-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: α,α,α',α'-Tetramethyl-adipinsaeure-dimethylester
• 英文别名: Dimethyl 2,2,5,5-tetramethylhexanedioate
• CAS: 17219-17-9
• 化学式: C₁₂H₂₂O₄
• 分子量: 230.304
• InChiKey: CLZWWDIVPSKZIL-UHFFFAOYSA-N

物化性质

• 熔点：
  46-47 °C
• 沸点：
  106-109 °C(Press: 6 Torr)
• 密度：
  0.985±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  α,α,α',α'-Tetramethyl-adipinsaeure-dimethylester 在 4-二甲氨基吡啶 、 sodium 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 76.0h， 生成 (1'S,2'S)-(2'-hydroxy-3',3',6',6'-tetramethyl)cyclohexyl (S)-1-benzoyl-2-pyrrolidine-carboxylate
  参考文献：
  名称：

  Syntheses of new C2-symmetric, optically active 1,2-diols bearing tertiary alkyl groups

  摘要：

  New C-2-symmetric chiral 1,2-diols, 1,2-bis(1-adamantyl)-1,2-ethanediol and 3,3,6,6-tetramethyl-1,2-cyclohexanediol, were synthesized by the use of a new resolution method. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00325-0
• 作为产物：
  描述：

  2,2-Dimethylcyclopropanon-methyl-hemiacetal 在 ammonium hydroxide 、 copper(II) sulfate 作用下， 生成 α,α,α',α'-Tetramethyl-adipinsaeure-dimethylester
  参考文献：
  名称：

  Schaafsma,S.E. et al., Recueil des Travaux Chimiques des Pays-Bas, 1968, vol. 87, p. 1301 - 1312

  摘要：

  DOI：

文献信息

• [EN] SYNTHESIS OF LIGANDS FOR USE IN ACTINIDE EXTRACTION<br/>[FR] SYNTHÈSE DE LIGANDS UTILISABLES POUR L'EXTRACTION D'ACTINIDES
  申请人：UNIV READING

  公开号：WO2011077081A1

  公开（公告）日：2011-06-30

  The invention discloses an improved process for the preparation of 2,2,5,5-tetrasubstituted hexane-1,6-dicarbonyl compounds, and in particular diethyl 2,2,5,5-tetramethylhexanedioate and dimethyl 2,2,5,5-tetramethylhexanedioate, by the alkylation of 1,2-difunctional ethane compounds with enolates of carbonyl compounds. The process provides higher yields and greater synthetic brevity than existing processes.

  该发明披露了一种改进的工艺，用于制备2,2,5,5-四取代己烷-1,6-二酮化合物，特别是通过将1,2-二官能乙烷化合物与羰基化合物的烯醇酸盐进行烷基化来制备二乙酯-2,2,5,5-四甲基己二酸和二甲酯-2,2,5,5-四甲基己二酸。该工艺提供了比现有工艺更高的收率和更大的合成简洁性。
• [EN] BRANCHED ADIPIC ACID BASED ESTERS AS NOVEL BASE STOCKS AND LUBRICANTS<br/>[FR] ESTERS À BASE D'ACIDE ADIPIQUE RAMIFIÉ UTILISÉS EN TANT QUE NOUVELLES HUILES DE BASE ET LUBRIFIANTS
  申请人：BASF SE

  公开号：WO2019110355A1

  公开（公告）日：2019-06-13

  The presently claimed invention is directed to the use of branched adipic acid esters as lubricants as well as lubricant compositions containing the branched adipic acid esters.

  目前所声称的发明涉及使用分支脂肪族己二酸酯作为润滑剂，以及包含分支脂肪族己二酸酯的润滑剂组合物。
• Effects of oral and transdermal 17β-estradiol with cyclical oral norethindrone acetate on insulin sensitivity, secretion, and elimination in postmenopausal women
  作者：Christopher P. Spencer、Ian F. Godsland、Alison J. Cooper、David Ross、Malcolm I. Whitehead、John C. Stevenson

  DOI：10.1053/meta.2000.6238

  日期：2000.6

  Few studies have examined the effects of 17 beta-estradiol on parameters of insulin and glucose metabolism. We studied 42 healthy, untreated postmenopausal women seeking relief from menopausal symptoms. They were randomized to receive either oral 17 beta-estradiol 2 mg daily combined with sequential oral norethindrone acetate (NETA) 1 mg daily from days 12 to 22, or transdermal 17 beta-estradiol 0.05 mg daily combined with sequential oral NETA 1 mg daily from days 17 to 28. Intravenous glucose tolerance tests (IVGTTs) were performed at baseline and after 48 weeks (estrogen-alone phase) and 48 weeks (combined phase) of completed therapy. Mathematical modeling analysis of plasma glucose, insulin, and C-peptide concentration profiles provided measures of insulin resistance, secretion, and elimination. Both types of therapy were associated with a decrease in fasting insulin and glucose levels. Insulin sensitivity was increased by oral estradiol during the estrogen-alone phase but was reversed by the addition of NETA. Transdermal estradiol did not affect insulin sensitivity. Hepatic insulin uptake and insulin secretion were increased with both types of treatment. The oral regimen of estradiol therapy was favorable to both insulin elimination and sensitivity. Transdermal estradiol therapy had relatively few effects on insulin metabolism. Copyright (C) 2000 by W.B. Saunders Company.
• Abderrahman, Ben Moufida; Laurent, Eliane; Marquet, Bernard, Bulletin de la Societe Chimique de France, 1988, # 3, p. 571 - 578
  作者：Abderrahman, Ben Moufida、Laurent, Eliane、Marquet, Bernard

  DOI：——

  日期：——
• SYNTHESIS OF LIGANDS FOR USE IN ACTINIDE EXTRACTION
  申请人：The University of Reading

  公开号：EP2516378A1

  公开（公告）日：2012-10-31