PAPAVERINE ANALOGS. IV. 1-CYCLOALIPHATIC-6,7-DIMETHOXYISOQUINOLINES
作者:EDWIN R. SHEPARD、JOHN F. NOTH
DOI:10.1021/jo01368a020
日期:1954.3
PHARMACOLOGICAL AGENTS FOR TREATING OCULAR DISEASES
申请人:CALASIA PHARMACEUTICALS, INC.
公开号:US20210154213A1
公开(公告)日:2021-05-27
Methods of treating presbyopia or cataract in a subject in need thereof are provided. The methods require administering to the subject an effective amount of a composition comprising a compound that inhibits the formation of high molecular weight aggregates of human α-A-crystallin. Compositions containing certain compounds are believed to be also effective in the treatment of transthyretin (TTR)-associated amyloidosis and Parkinson's disease.