20,21-二去氢-(15alpha)-18-去甲柯楠-19-醛 | 136573-96-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 20,21-二去氢-(15alpha)-18-去甲柯楠-19-醛
• 英文名称: (2R,12bS)-2-ethyl-1,2,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine-3-carbaldehyde
• CAS: 136573-96-1
• 化学式: C₁₈H₂₀N₂O
• 分子量: 280.37
• InChiKey: JBKVPQNVVZLHBE-PXAZEXFGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  36.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (1R,2R)-N,N'-二甲基-1,2-二苯基-1,2-乙二胺 在 二甲基硫 、 4 A molecular sieve 、 copper(I) bromide 、 lithium bromide 作用下， 以 乙醚 为溶剂， 反应 0.83h， 生成 20,21-二去氢-(15alpha)-18-去甲柯楠-19-醛
  参考文献：
  名称：

  Preparation and Utilization of Chiral Dihydropyridines. Synthesis of Chiral Indoloquinolizines and Benzoquinolizines

  摘要：

  An asymmetric synthesis of 3-formyl-1,4-dihydropyridines is described that entails the addition of organocopper reagents to activated 3-imidazolidinylpyridine, prepared with chiral diamines. The activator can be a chloroformate or an acid chloride. The methodology was used for the asymmetric syntheses of the indoloquinolizine and benzoquinolizine alkaloid frameworks.

  DOI：

  10.1021/jo00086a045

文献信息

• Enantioselective synthesis of indoloquinolizidines
  作者：Pierre Mangeney、Romain Gosmini、Alexandre Alexakis

  DOI：10.1016/0040-4039(91)80605-6

  日期：1991.8

  Asymmetric synthesis of indoloquinolizidine has been accomplished by using acyl pyridinium salt bearing in 3 position a chiral aminal.

  通过使用在手性缩醛的3位上带有酰基吡啶鎓盐，可以完成吲哚并喹喔啉的不对称合成。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577B1

  公开（公告）日：2018-12-12
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
• Preparation and Utilization of Chiral Dihydropyridines. Synthesis of Chiral Indoloquinolizines and Benzoquinolizines
  作者：Pierre Mangeney、Romain Gosmini、Sabine Raussou、Monique Commercon、Alexandre Alexakis

  DOI：10.1021/jo00086a045

  日期：1994.4

  An asymmetric synthesis of 3-formyl-1,4-dihydropyridines is described that entails the addition of organocopper reagents to activated 3-imidazolidinylpyridine, prepared with chiral diamines. The activator can be a chloroformate or an acid chloride. The methodology was used for the asymmetric syntheses of the indoloquinolizine and benzoquinolizine alkaloid frameworks.