3-(1,1-dimethyl-2-oxo-propyl)-glutaric acid | 99974-72-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(1,1-dimethyl-2-oxo-propyl)-glutaric acid
• 英文别名: 3-(1,1-Dimethyl-2-oxo-propyl)-glutarsaeure；Isoketocamphersaeure；Isooxycamphersaeure
• CAS: 99974-72-8
• 化学式: C₁₀H₁₆O₅
• 分子量: 216.234
• InChiKey: WLXCRBOZJKAXCC-UHFFFAOYSA-N

物化性质

• 熔点：
  133 °C
• 沸点：
  401.9±25.0 °C(Predicted)
• 密度：
  1.198±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.17
• 重原子数：
  15.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  91.67
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  3-(1,1-dimethyl-2-oxo-propyl)-glutaric acid 生成 異樟衍酸
  参考文献：
  名称：

  Tiemann, Chemische Berichte, 1895, vol. 28, p. 2174

  摘要：

  DOI：
• 作为产物：
  描述：

  ((1R,3Ξ,4Ξ)-3,4-dihydroxy-2,2,3-trimethyl-cyclopentyl)-acetic acid 在 硫酸 、 水 、 铬酸 作用下， 生成 3-(1,1-dimethyl-2-oxo-propyl)-glutaric acid
  参考文献：
  名称：

  Tiemann, Chemische Berichte, 1896, vol. 29, p. 3007

  摘要：

  DOI：

文献信息

• Reactions of Terpenes. IV.¹ Reaction of α-Pinene Oxide with p-Toluenesulfonic Acid and Quinaldine
  作者：L. CARROLL KING、HUGH FARBER

  DOI：10.1021/jo01061a012

  日期：1961.2
• Space shuttle observations of terrestrial impact structures using SIR-C and X-SAR radars
  作者：John F. Mchone、Ronald Greeley、Kevin K. Williams、Dan G. Blumberg、Ruslan O. Kuzmin

  DOI：10.1111/j.1945-5100.2002.tb00824.x

  日期：2002.3

  Abstract— Ten terrestrial impact structures were imaged during two flights of the 1994 space radar laboratory (SRL) experiment. These craters include Wolf Creek, Australia; Roter Kamm, Namibia; Zhamanshin, Kazakhstan; BP and Oasis, Libya; Aorounga, Chad; Amguid, Algeria; and Spider, Connolly Basin and Henbury, Australia. SRL contained two co‐registered instruments; the United States shuttle imaging radar‐C (SIR‐C) polarimetric radar system operating in L‐band (λ = 24 cm) and C‐band (λ = 5.6 cm), and the joint German/Italian synthetic aperture radar (X‐SAR) operating in vertically‐polarized X‐band (λ = 3 cm).Comparisons show SRL images to be complementary to, or in some cases superior to, corresponding optical images for evaluating size, location, and relative age of impact features. Regardless of wavelength or polarization, craters with significant relief appear prominently on radar as a result of slope and roughness effects. In desert regions, longer wavelengths penetrate dry sand mantles to reveal hidden crater dimensions or associated buried landforms. Radar polarities and wavelengths are particularly sensitive to vegetation, surface roughness, and soil moisture or electrical properties. In the more temperate environments of Kazakhstan and Australia, SRL images show detailed stream patterns that reveal the location and structure of otherwise obscured impact features.
• Bredt-Savelsberg; Buchkremer, Chemische Berichte, 1931, vol. 64, p. 600
  作者：Bredt-Savelsberg、Buchkremer

  DOI：——

  日期：——
• Tiemann; Semmler, Chemische Berichte, 1895, vol. 28, p. 1345
  作者：Tiemann、Semmler

  DOI：——

  日期：——
• Increased levels of advanced glycosylation end products in the kidney and liver from spontaneously diabetic Chinese hamsters determined by immunochemical assay
  作者：Atsuko Abiko、Masaaki Eto、Isao Makino、Norie Araki、Seikoh Horiuchi

  DOI：10.1016/s0026-0495(00)80029-3

  日期：2000.5

  Increased levels of advanced glycosylation end products (AGEs) have been reported in tissues in association with diabetes mellitus. Thus, we measured tissue AGE levels and detected an accumulation of AGEs in the kidney and liver from spontaneously diabetic Chinese hamsters (CHAD) to determine the relationship between AGEs and diabetes mellitus. Diabetic CHAD aged 12 to 13 months were studied together with age-matched nondiabetic CHAD. We used an AGE-specific noncompetitive enzyme-linked immunosorbent assay (ELISA) with polyclonal anti-AGE-bovine serum albumin (BSA) antibody to measure tissue AGE levels. The samples extracted from the kidney and liver obtained from diabetic and nondiabetic CHAD reacted with anti-AGE-BSA antibody. When the absorbance of standard AGE-BSA (0.1 mu g/mL) was expressed as 1 U, AGE levels in the kidney and liver from diabetic CHAD were significantly increased as compared with nondiabetic CHAD (kidney, 0.26 +/- 0.05 v 0.10 +/- 0.03 U/mu g protein, P < .01; liver, 0.20 +/- 0.03 v 0.09 +/- 0.02 U/mu g protein, P < .01). Positive AGE staining was observed in the renal cortex, especially in the tubules of diabetic CHAD, but little AGE staining was observed in the glomerulus by the immunohistochemical study. AGE staining was diffuse in the hepatocytes. These AGE levels were significantly correlated with fasting plasma glucose and glycated hemoglobin (P < .01, respectively). In conclusion, we have confirmed that AGE structures were expressed in the kidney and liver from CHAD, and these AGE levels were increased in diabetic CHAD. AGE staining was observed in the renal tubules and hepatocytes. Tissue AGE levels were positively correlated with glycemic control in CHAD. Copyright (C) 2000 by W.B. Saunders Company.