bis(2-phenylprop-2-yl)ether | 74563-04-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(2-phenylprop-2-yl)ether
• 英文别名: bis(2-phenylpropyl)ether；Dicumyl ether；2-(2-phenylpropan-2-yloxy)propan-2-ylbenzene
• CAS: 74563-04-5
• 化学式: C₁₈H₂₂O
• 分子量: 254.372
• InChiKey: PZHXTCOVSRHUSS-UHFFFAOYSA-N

物化性质

• 沸点：
  329.4±11.0 °C(Predicted)
• 密度：
  0.989±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  bis(2-methylphenyl)methanol 在 tris(triphenylphosphine)ruthenium(II) chloride 作用下， 以 various solvent(s) 为溶剂， 生成 bis(2-phenylprop-2-yl)ether
  参考文献：
  名称：

  Transformation of carbinols by dichlorotris(triphenylphosphine)ruthenium and by some other transition-metal catalysts

  摘要：

  DOI：

  10.1021/jo01310a031

文献信息

• Reactivity of bismuth(III) halides towards alcohols. A tentative to mechanistic investigation
  作者：El Mehdi Keramane、Bernard Boyer、Jean-Pierre Roque

  DOI：10.1016/s0040-4020(01)00013-8

  日期：2001.3

  bismuth(III) halides (BiX3; X=Cl, Br and I) towards a series of alcohols has been investigated. Three different reactions have been studied, namely: halogenation, dehydration and etherification. The behaviour of these bismuth derivatives was found to depend on the nature of the halide bonded to the bismuth atom. Their reactivities can be interpreted on the basis of the Hard and Soft Acids and Bases

  研究了卤化铋（III）（BiX 3； X = Cl，Br和I）对一系列醇的反应性。已经研究了三种不同的反应，即：卤化，脱水和醚化。发现这些铋衍生物的行为取决于结合到铋原子上的卤化物的性质。它们的反应性可以根据硬酸和软酸和碱（HSAB）原理进行解释。提出了一种机制，该机制涉及形成醇与Bi（III）的复合物。
• Unusual case of catalysis by palladium clusters
  作者：I. P. Stolarov、Zh. V. Dobrokhotova、G. N. Kryukova、N. Yu. Kozitsyna、A. E. Gekhman、M. N. Vargaftik、I. I. Moiseev

  DOI：10.1007/s11172-005-0324-2

  日期：2005.3

  An unusual for Pd catalysts dehydration of α-alkyl and α, α′-dialkylbenzyl alcohols PhCR′R″OH (R′ = H, Me, Et, Bu; R″ = H, Me) occurs in the presence of the palladium(I) cluster [Pd4(CO)4(OAc)4] (1) in an inert atmosphere to form ethers PhCR′R″-O-CR′ R″ and water. The catalyst is an intermediate of cluster 1 reduction to Pd black, while neither the starting cluster 1, nor Pd black, which is the decomposition product, are active in the catalysis of this reaction.

  一种对于Pd催化剂而言不寻常的脱水反应，即α-烷基和α,α′-二烷基苄醇PhCR′R″OH（R′=H、Me、Et、Bu；R″=H、Me）在惰性气氛中与钯(I)簇合物[Pd4(CO)4(OAc)4]（1）共存时，会生成醚PhCR′R″-O-CR′R″和水。该催化剂是簇合物1还原为Pd黑的过程中的中间体，而无论是起始的簇合物1还是其分解产物Pd黑，都不具有催化此反应的活性。
• [EN] SUBSTITUTED 2-NAPHTHOIC ACIDS AS ANTAGONISTS OF GPR105 ACTIVITY<br/>[FR] ACIDES 2-NAPHTOÏQUE SUBSTITUÉS EN TANT QU'ANTAGONISTES DE L'ACTIVITÉ DE GPR105
  申请人：MERCK FROSST CANADA LTD

  公开号：WO2009070873A1

  公开（公告）日：2009-06-11

  Substituted 2-naphthoic acids of structural formula I are effective as antagonists of the biological activity of GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and conditions associated with the Metabolic Syndrome.

  结构式I中的2-萘甲酸替代物对GPR105蛋白的生物活性具有拮抗作用。它们可用于治疗、控制或预防对该受体拮抗有响应的疾病，如糖尿病，特别是2型糖尿病，胰岛素抵抗，高血糖，脂质紊乱，肥胖，动脉粥样硬化以及与代谢综合征相关的疾病。
• [EN] PROCESS FOR PREPARING AN ARYLALKYL COMPOUND<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN COMPOSÉ D'ARYLALKYLE
  申请人：SHELL INT RESEARCH

  公开号：WO2009021866A1

  公开（公告）日：2009-02-19

  The invention relates to a process for preparing an arylalkyl compound, which comprises contacting a feed comprising a bis(arylalkyl)ether with hydrogen in the presence of a catalyst at elevated temperature.

  该发明涉及一种制备芳基烷基化合物的过程，包括在催化剂存在下，将含有双(芳基烷基)醚的原料与氢气在高温下接触。
• POLY(ORGANOPHOSPHAZENE) COMPOSITION FOR BIOMATERIALS
  申请人：SONG Soo-Chang

  公开号：US20130004455A1

  公开（公告）日：2013-01-03

  Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.

  提供了一种用于生物材料的化学交联可用的聚（有机磷氮烷）的用途，与生理活性物质共价结合的化学交联聚（有机磷氮烷），以及其用于生物材料的用途，以及制备这些材料的过程。这种化学交联可以通过紫外辐射、交联剂、添加剂、酶、至少一种聚合物的混合等方法实现。