pivaloyloxymethyl bromide | 40796-22-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: pivaloyloxymethyl bromide
• 英文别名: Bromomethyl pivalate；bromomethyl 2,2-dimethylpropanoate
• CAS: 40796-22-3
• 化学式: C₆H₁₁BrO₂
• 分子量: 195.056
• InChiKey: ACBDNFPUXYGKPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  pivaloyloxymethyl bromide 在 2,6-二甲基吡啶 、 六甲基磷酰三胺 、 氯化亚砜 、 3 A molecular sieve 、 potassium carbonate 作用下， 反应 5.0h， 生成 (5R,6S)-7-Oxo-6-(2-oxo-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester
  参考文献：
  名称：

  Bateson, John H.; Quinn, Alison M.; Smale, Terence C., Journal of the Chemical Society. Perkin transactions I, 1985, p. 2219 - 2234

  摘要：

  DOI：

文献信息

• .beta.-Lactam antibacterial agents
  申请人：Beecham Group Limited

  公开号：US04350703A1

  公开（公告）日：1982-09-21

  Compounds are described of the formula (II): ##STR1## wherein R.sub.1 is a group such that CO.sub.2 R.sub.1 is an ester group; A.sub.1 is a hydrogen atom; and A.sub.2 is a group CR.sub.2 R.sub.3 R.sub.4 wherein R.sub.2 is a hydrogen atom or a hydroxyl group; R.sub.3 is a hydrogen atom or a lower alkyl group; and R.sub.4 is a hydrogen atom or a lower alkyl group, a benzyl group, a phenyl group or is joined to R.sub.3 to form part of a C.sub.5-7 carboxylic ring or is a group of the formula CH(OH)R.sub.5 or CHX wherein R.sub.5 is a hydrogen atom or lower alkyl group and X is an oxygen atom or a CR.sub.6 R.sub.7 group where R.sub.6 is a hydrogen atom or a lower alkyl, phenyl, CN, CO.sub.2 R.sub.8 where R.sub.8 is a lower alkyl, phenyl or benzyl group and R.sub.7 is a hydrogen atom or a lower alkyl group or is joined to R.sub.6 to form part of a C.sub.5-7 carbocyclic ring. These compounds have been found to possess antibacterial properties. The preparation of these compounds is described.

  描述的化合物公式为(II): ##STR1## 其中R1是一个基团，使得CO2R1是一个酯基团；A1是一个氢原子；A2是一个CR2R3R4基团，其中R2是一个氢原子或一个羟基；R3是一个氢原子或一个低级烷基团；R4是一个氢原子或一个低级烷基团、苄基团、苯基团或与R3结合形成一个C5-7羧酸环，或者是一个CH(OH)R5或CHX基团，其中R5是一个氢原子或低级烷基团，X是一个氧原子或一个CR6R7基团，其中R6是一个氢原子或低级烷基、苯基、CN、CO2R8，其中R8是一个低级烷基、苯基或苄基团，R7是一个氢原子或低级烷基团或与R6结合形成一个C5-7碳环。这些化合物具有抗菌性质。这些化合物的制备方法已经描述。
• 4-Allyl azetidinone intermediate for .beta.-lactam antibacterial agents
  申请人：Beecham Group Limited

  公开号：US04401595A1

  公开（公告）日：1983-08-30

  Compounds are provided of the formula (II): ##STR1## wherein R.sub.1 is a group such that CO.sub.2 R.sub.1 is an ester group and A.sub.1 is a hydrogen atom or a methyl group. These compounds possess antibacterial activity. The preparation of these compounds is described.

  提供以下化合物的公式（II）：##STR1## 其中R₁是一个基团，使得CO₂R₁是一个酯基团，并且A₁是一个氢原子或甲基。这些化合物具有抗菌活性。这些化合物的制备方法如下所述。
• Cephalosporins and homologues, preparations and pharmaceutical
  申请人：——

  公开号：US06001997A1

  公开（公告）日：1999-12-14

  .beta.-Lactam antibiotics of formula (I) or a salt thereof, wherein R.sup.1 is hydrogen, methoxy or formamido; R.sup.2 is an acyl group; CO.sub.2 R.sup.3 is a carboxy group or a carboxylate anion, or R.sup.3 is a readily removable carboxy protecting group; R.sup.4 represents up to four substituents; X is S, SO, SO.sub.2, O or CH.sub.2 ; m is 1 or 2; and n is 0, useful in the treatment of bacterial infections. ##STR1##

  (1)式β-内酰胺类抗生素或其盐，其中R1为氢、甲氧基或甲酰胺基；R2为酰基；CO2R3为羧基或羧酸根离子，或R3为易于去除的羧基保护基团；R4代表最多四个取代基；X为S、SO、SO2、O或CH2；m为1或2；n为0，用于治疗细菌感染。
• 2.beta.-Chloromethyl-2.alpha.-methylpenam-3.alpha.-carboxylic acid
  申请人：Bristol-Myers Company

  公开号：US04380512A1

  公开（公告）日：1983-04-19

  2.beta.-Chloromethyl-2.alpha.-methylpenam-3.alpha.-carboxylic acid sulfone and salts and esters thereof were synthesized and found to be potent inhibitors of .beta.-lactamases.

  2-β-氯甲基-2-α-甲基青霉烷-3-α-羧酸磺酰和其盐和酯类化合物被合成，并发现它们是β-内酰胺酶的有效抑制剂。
• Derivatives of 6-bromo penicillanic acid
  申请人：Bristol-Myers Company

  公开号：US04340539A1

  公开（公告）日：1982-07-20

  2.beta.-Chloromethyl-2.alpha.-methylpenam-3.alpha.-carboxylic acid sulfone and salts and esters thereof were synthesized and found to be potent inhibitors of .beta.-lactamases.

  2-氯甲基-2-α-甲基青霉烷-3-α-羧酸磺酰和其盐和酯类物质被合成，并发现它们是β-内酰胺酶的有效抑制剂。