Gold(I)-Catalyzed Synthesis of 3-Sulfenyl Pyrroles and Indoles by a Regioselective Annulation of Alkynyl Thioethers
作者:Peter E. Simm、Prakash Sekar、Jeffery Richardson、Paul W. Davies
DOI:10.1021/acscatal.1c01457
日期:2021.6.4
synthesis. Accessing more varied heterocycle-substitution patterns by maintaining the same reaction pathways across different alkynes remains a challenge. Here we show that Au(I) catalysis of isoxazole-based nitrenoids with alkynyl thioethers provides controlled access to (3 + 2) annulation by a regioselective addition β to the sulfenyl group. The reaction with isoxazole-containing nitrenoids delivers
Synthesis and anti-fungal properties of some simple cyclopentenones and derivatives
作者:J.Allen Miller、Ashley W Pugh、G.Mustafa Ullah、G.Malcolm Welsh
DOI:10.1016/s0040-4039(00)02110-9
日期:2001.1
1-Methylsulphenyl-2-phenylsulphenylethyne has been shown to be a precursor for either α-sulphenyl ketone or α-methylene ketone moieties in cyclopentenoids produced via [3+2] cycloaddition of an allyl cation. One of these ketones, the α-sulphenyl cyclopentenone 5, has been found to display potency against a range of fungi in vitro but its close analogues are largely inactive.