4-[2-(biphenyl-4-yloxy)ethoxy]benzaldehyde | 144829-03-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[2-(biphenyl-4-yloxy)ethoxy]benzaldehyde
• 英文别名: 4-[2-(4-Phenylphenoxy)ethoxy]benzaldehyde
• CAS: 144829-03-8
• 化学式: C₂₁H₁₈O₃
• 分子量: 318.372
• InChiKey: LSEMWNQZKPGCRD-UHFFFAOYSA-N

物化性质

• 沸点：
  519.4±40.0 °C(Predicted)
• 密度：
  1.156±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-[2-(biphenyl-4-yloxy)ethoxy]benzaldehyde 在 palladium on activated charcoal sodium hydroxide 、 potassium tert-butylate 、 氢气 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 、 叔丁醇 为溶剂， 反应 3.0h， 生成 3-{4-[2-(Biphenyl-4-yloxy)-ethoxy]-phenyl}-2-methoxy-propionic acid
  参考文献：
  名称：

  Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists

  摘要：

  A series of 2-alkoxydihydrocinnamates were synthesized as PPAR gamma and PPAR alpha dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPAR alpha/gamma dual agonist and will be further evaluated for the treatment of type II diabetes. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2005.10.104
• 作为产物：
  描述：

  对羟基联苯 、 4-(2-溴乙氧基)苯甲醛 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-[2-(biphenyl-4-yloxy)ethoxy]benzaldehyde
  参考文献：
  名称：

  Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists

  摘要：

  A series of 2-alkoxydihydrocinnamates were synthesized as PPAR gamma and PPAR alpha dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPAR alpha/gamma dual agonist and will be further evaluated for the treatment of type II diabetes. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2005.10.104

文献信息

• Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists
  作者：Ying Lu、Zongru Guo、Yanshen Guo、Jun Feng、Fengming Chu

  DOI：10.1016/j.bmcl.2005.10.104

  日期：2006.2

  A series of 2-alkoxydihydrocinnamates were synthesized as PPAR gamma and PPAR alpha dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPAR alpha/gamma dual agonist and will be further evaluated for the treatment of type II diabetes. (c) 2006 Published by Elsevier Ltd.