N'-benzoyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide | 380558-80-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N'-benzoyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide
• 英文别名: N'-[2-(1H-indol-3-yl)-2-oxoacetyl]benzohydrazide
• CAS: 380558-80-5
• 化学式: C₁₇H₁₃N₃O₃
• 分子量: 307.309
• InChiKey: UHSIYSGSCIBAKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吲哚-3-乙醛酰氯 、 苯甲酰肼 在 三乙胺 作用下， 以 甲基叔丁基醚 为溶剂， 反应 2.75h， 以30%的产率得到N'-benzoyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide
  参考文献：
  名称：

  Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure

  摘要：

  The N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide motif was identified as a novel scaffold for the development of kinase inhibitors. Derivatives with a biphenyl element attached to the hydrazide structure proved to be submicromolar dual inhibitors of the cancer-related kinases IGF-1R and SRC. One of the most potent kinase inhibitors of the series produced a selective growth inhibition in a panel of cultivated cancer cell lines. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.03.065

文献信息

• Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure
  作者：Stefanie Schmidt、Lutz Preu、Thomas Lemcke、Frank Totzke、Christoph Schächtele、Michael H.G. Kubbutat、Conrad Kunick

  DOI：10.1016/j.ejmech.2011.03.065

  日期：2011.7

  The N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide motif was identified as a novel scaffold for the development of kinase inhibitors. Derivatives with a biphenyl element attached to the hydrazide structure proved to be submicromolar dual inhibitors of the cancer-related kinases IGF-1R and SRC. One of the most potent kinase inhibitors of the series produced a selective growth inhibition in a panel of cultivated cancer cell lines. (C) 2011 Elsevier Masson SAS. All rights reserved.