4'-Chlor-2-methyl-acetessigsaeureanilid | 19359-17-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-Chlor-2-methyl-acetessigsaeureanilid
• 英文别名: α-methyl-4-chloroacetoacetanilide；N-(4-chlorophenyl)-2-methyl-3-oxobutanamide
• CAS: 19359-17-2
• 化学式: C₁₁H₁₂ClNO₂
• 分子量: 225.675
• InChiKey: XHVLTXIWHJWBAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4'-Chlor-2-methyl-acetessigsaeureanilid 在 potassium carbonate 、 溶剂黄146 作用下， 以 甲醇 、 丙酮 为溶剂， 生成 2-benzyl-N-(4-chlorophenyl)-2-methyl-3-(2-(4-nitrophenyl)hydrazineylidene)butanamide
  参考文献：
  名称：

  Inter- and Intramolecular Cyclisation Reactions of Azoacetates Derived from Aryl Hydrazones of Ethylacetoacetate and Acetoacetanilides

  摘要：

  DOI：

  10.3987/com-08-11433
• 作为产物：
  描述：

  乙酰基乙酰对氯苯胺 、 碘甲烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 4'-Chlor-2-methyl-acetessigsaeureanilid
  参考文献：
  名称：

  Synthesis and X-Ray Crystal Structure Determinations of Pyrrolidine-2,4-diones, 2-Iminopyrrolidin-5-ones and 1,3-Oxazine-2,4-diones Derived from Acetoacetanilides

  摘要：

  DOI：

  10.3987/com-05-10568

文献信息

• Reagent-controlled enantioselectivity switch for the asymmetric fluorination of β-ketocarbonyls by chiral primary amine catalysis
  作者：Yang'en You、Long Zhang、Sanzhong Luo

  DOI：10.1039/c6sc03109a

  日期：——

  enantioselectivity switch was uncovered in the asymmetric α-fluorination of β-ketocarbonyls by a chiral primary amine catalyst. By a simple swap of fluorination reagents, both enantiomers of the quaternary fluorination adducts could be obtained with good yields and high enantioselectivity. Mechanistic studies disclosed dual H-bonding and electrostatic stereocontrolling modes for the catalysis.

  通过手性伯胺催化剂在β-酮羰基的不对称α-氟化反应中未发现试剂控制的对映选择性开关。通过简单地交换氟化试剂，可以以良好的产率和高的对映选择性获得季氟化加合物的两种对映异构体。机理研究揭示了催化的双重氢键结合和静电立体控制方式。
• Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400
  作者：Jingjing Bi、Zhiguo Zhang、Qingfeng Liu、Guisheng Zhang

  DOI：10.1039/c2gc16661e

  日期：——

  Series of α-mono-fluorinated acetoacetamides were synthesized under mild condition with industrialized Selectfluor as the F+ source in PEG-400. The approach avoided the use of base or metal catalyst, and most of cases proceeded in nearly quantitative conversions regardless of the electronic nature of the diversity substituent.

  一系列α-单氟乙酰胺在PEG-400中使用工业化Selectfluor作为F+源，在温和条件下被合成。该方法避免了使用碱或金属催化剂，并且在大多数情况下，无论多样性取代基的电子性质如何，都能实现几乎定量的转化。
• Copolymerizable azo compounds and articles containing them
  申请人：Pearson Jason Clay

  公开号：US20080182957A1

  公开（公告）日：2008-07-31

  Polymerizable light absorbing azo dyes are disclosed useful as monomers in the formation of devices such as, but not limited to ocular lenses. Specifically, intraocular lenses (IOL) are disclosed wherein one or more of the light absorbing dye is covalently bonded to other structural polymers though ethylene unsaturated groups. The resulting IOLs possess light absorbing properties without significant amounts of free (un-bound) azo dye molecules present in the final structural polymer matrix.
• US7326423B2
  申请人：——

  公开号：US7326423B2

  公开（公告）日：2008-02-05
• US8188203B2
  申请人：——

  公开号：US8188203B2

  公开（公告）日：2012-05-29