(4-fluorophenyl)-phenylamino-acetic acid | 124573-81-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4-fluorophenyl)-phenylamino-acetic acid
• 英文别名: 2-(4-fluorophenyl)-N-phenylglycine；2-Anilino-2-(4-fluorophenyl)acetic acid
• CAS: 124573-81-5
• 化学式: C₁₄H₁₂FNO₂
• 分子量: 245.253
• InChiKey: OBAAFOUXBVWAIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (4-fluorophenyl)-phenylamino-acetic acid 在 盐酸 、 乙酸酐 、 sodium nitrite 作用下， 生成 4-(4-fluorophenyl)-3-phenyl-1,2,3-oxadiazol-3-ium-5-olate
  参考文献：
  名称：

  Csongar, Ch.; Mueller, I.; Slezak, H., Journal fur praktische Chemie (Leipzig 1954), 1988, vol. 330, # 6, p. 1006 - 1014

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(4-Fluoro-phenyl)-2-phenylamino-acetamide 在 盐酸 作用下， 反应 10.0h， 以70%的产率得到(4-fluorophenyl)-phenylamino-acetic acid
  参考文献：
  名称：

  Csongar, Ch.; Mueller, I.; Slezak, H., Journal fur praktische Chemie (Leipzig 1954), 1988, vol. 330, # 6, p. 1006 - 1014

  摘要：

  DOI：

文献信息

• [EN] ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF<br/>[FR] DÉRIVÉS AMINOESTÉRIFIÉS D'ALCALOÏDES ET COMPOSITION MÉDICINALE LES INCLUANT
  申请人：CHIESI FARMA SPA

  公开号：WO2010072338A1

  公开（公告）日：2010-07-01

  The present invention relates to alkaloid aminoester derivatives acting as muscarinic receptor antagonists, to methods of preparing such derivatives, to compositions comprising them and therapeutic use thereof.

  本发明涉及作为毒蕈碱受体拮抗剂的生物碱氨基酸酯衍生物，制备此类衍生物的方法，包含它们的组合物以及它们的治疗用途。
• Ugi four-component condensation with two cleavable components: the easiest synthesis of 2,N-diarylglycines
  作者：Cristina Faggi、Ana G. Neo、Stefano Marcaccini、Gloria Menchi、Julia Revuelta

  DOI：10.1016/j.tetlet.2008.01.134

  日期：2008.3

  The Ugi four-component condensation between anilines, aromatic aldehydes, isocyanides, and α-oxoacids afforded the expected adducts which were cleaved in mild conditions to give 2,N-diarylglycines in high yields.

  苯胺，芳族醛，异氰酸酯和α-含氧酸之间的Ugi四组分缩合反应可提供预期的加合物，将其在温和条件下裂解，可高收率得到2，N-二芳基甘氨酸。
• ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF
  申请人：Caligiuri Antonio

  公开号：US20100173880A1

  公开（公告）日：2010-07-08

  Alkaloid aminoester compounds which act as muscarinic receptor antagonists are useful for the prevention and/or treatment of a broncho-obstructive or inflammatory diseases.

  具有肌碱受体拮抗作用的生物碱氨酯化合物对于预防和/或治疗支气管阻塞性或炎症性疾病是有用的。
• Electrochemical carboxylation of fluorocontaining imines with preparation of fluorinated N-phenylphenylglycines
  作者：V.G. Koshechko、V.E. Titov、V.N. Bondarenko、V.D. Pokhodenko

  DOI：10.1016/j.jfluchem.2008.06.010

  日期：2008.8

  A possibility of obtaining fluorine-containing N-phenylphenylglycine derivatives at yields of up to 85% via the electrochemical carboxylation of corresponding benzalanilines was shown. The influence of imine's electron structure, the nature of supporting electrolyte and cathodic material on such processes is examined. It was found, that increasing electron accepting ability of the substituents in benzylidene and aniline fragments of the imine molecule lead to decrease of amino acid yields. The dependence of the N-phenyl-p-fluorophenylglycine yield on the cathode material (Zn, GC, Cu, Ag, Pt) and on the nature of the supporting electrolytes (Bu4NBr, Et4NBr, Et4NClO4, PhCH2Me3NClO4, LiBF4, LiClO4, NaBF4 and KBF4) Was investigated. The highest amino acid yields were obtained at cathodes (GC and Zn) that do not exhibit specific adsorption of fluorine-containing imines, as well as in the presence of background salts (Alk(4)NBr) whose cations do not show tendency to strong ion pairing with anion radicals formed by the electrochemical activation of the imines. (c) 2008 Elsevier B.V. All rights reserved.
• Alkaloid aminoester derivatives and medicinal composition thereof
  申请人：Chiesi Farmaceutici S.p.A.

  公开号：EP2376489A1

  公开（公告）日：2011-10-19