2-methylpyrazolo[1,5-a]pyridin-3-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 2-methylpyrazolo[1,5-a]pyridin-3-amine
• 英文别名: 2-methyl-3-amino-pyrazolo[1,5-a]pyridine；3-amino-2-methylpyrazolo[1,5-a]pyridine
• 化学式: C₈H₉N₃
• mdl: MFCD19207722
• 分子量: 147.18
• InChiKey: LUPGXQQJVQCMGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  43.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methylpyrazolo[1,5-a]pyridin-3-amine 、 3-戊酮 在 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 18.0h， 以85%的产率得到N-(1-ethylpropyl)-2-methylpyrazolo[1,5-a]pyridin-3-amine
  参考文献：
  名称：

  Novel pyrazolo[1,5-a]pyridine derivatives and their use as neurotransmitter modulators

  摘要：

  本发明涉及一种新型的嘧啶并[1,5-a]吡啶衍生物，其一般化学式为I:1，能够与CRF1受体高亲和力结合，包括人类CRF1受体。本发明还涉及使用本发明的化合物治疗某种疾病或症状的方法，该疾病或症状的治疗可以通过拮抗CRF受体来实现或促进，例如中枢神经系统疾病或疾病，尤其是焦虑症、抑郁症和与压力相关的疾病。

  公开号：

  US20040002511A1

文献信息

• Composition for the dyeing of keratin fibers comprising at least one 3-amino-pyrazolopyridine derivatives
  申请人：Fadli Aziz

  公开号：US20070143935A1

  公开（公告）日：2007-06-28

  Disclosed herein is a composition for the dyeing of keratin fibers, for example, human keratin fibers such as the hair, comprising at least one 3-amino pyrazolo-[1,5-a]-pyridine derivative or one of its addition salts and a method employing this derivative. The composition of the present disclosure makes it possible to obtain coloration in various shades that is powerful, chromatic, and aesthetic, with low selectivity and with good resistance to various aggressive factors to which the hair may be subjected, such as shampoos, the light, sweat and permanent shaping.

  本公开涉及一种用于染色角蛋白纤维的组合物，例如，人类角蛋白纤维，如头发，包括至少一种3-氨基吡唑并[1,5-a]-吡啶衍生物或其加合盐以及采用该衍生物的方法。本公开的组合物使得可以获得各种色调的着色，具有强大、色彩丰富和美观的特性，具有低选择性，并且对头发可能受到的各种侵蚀因素具有良好的抵抗力，如洗发水、光线、汗水和永久造型。
• Pyrazolo[1,5-a]pyridine derivatives and their use as neurotransmitter modulators
  申请人：Pharmacia & Upjohn Company LLC

  公开号：US07151109B2

  公开（公告）日：2006-12-19

  The present invention relates to novel pyrazolo[1,5-a]pyridine derivatives of general formula I: that bind with high affifnity to CRF1 receptors, including human CRF1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety disorders, and depression and stress related disorders.

  本发明涉及一种新型的吡唑并[1,5-a]吡啶衍生物，其通式为I，可以与CRF1受体高亲和结合，包括人类CRF1受体。本发明还涉及使用本发明化合物治疗一种疾病或病症的方法，该病症的治疗可以通过拮抗CRF受体来实现或促进，例如中枢神经系统疾病或疾病，特别是焦虑症，抑郁症和与压力相关的疾病。
• COMPOSITION FOR THE DYEING OF KERATIN FIBERS COMPRISING AT LEAST ONE 3-AMINO-PYRAZOLOPYRIDINE DERIVATIVE
  申请人：Fadli Aziz

  公开号：US20100115711A1

  公开（公告）日：2010-05-13

  Disclosed herein is a composition for the dyeing of keratin fibers, for example, human keratin fibers such as the hair, comprising at least one 3-amino pyrazolo-[1,5-a]-pyridine derivative or one of its addition salts and a method employing this derivative. The composition of the present disclosure makes it possible to obtain coloration in various shades that is powerful, chromatic, and aesthetic, with low selectivity and with good resistance to various aggressive factors to which the hair may be subjected, such as shampoos, the light, sweat and permanent shaping.

  本文公开了一种用于染色角蛋白纤维（例如人类角蛋白纤维，如头发）的组合物，包括至少一种3-氨基吡唑并[1,5-a]-吡啶衍生物或其加合物盐以及采用该衍生物的方法。本公开的组合物使得能够获得各种强烈、色彩丰富、美观的染色效果，具有低选择性并对头发可能遭受的各种侵害因素具有良好的耐受性，例如洗发水、光线、汗水和永久造型。
• PYRAZOLO(1,5-A)PYRIDINE DERIVATIVES AS NEUROTRANSMITTER MODULATORS
  申请人：Pharmacia & Upjohn Company LLC

  公开号：EP1485384A1

  公开（公告）日：2004-12-15
• DYE COMPOSITION COMPRISING A HETEROCYCLIC OXIDATION BASE AND AN INDOLE COUPLER
  申请人：L'Oréal

  公开号：EP2464424B1

  公开（公告）日：2019-09-25