methyl 4-methyl-6-oxo-1-phenylpyridazine-3-carboxylate | 107516-97-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: methyl 4-methyl-6-oxo-1-phenylpyridazine-3-carboxylate
• 英文别名: 4-methyl-6-oxo-1-phenyl-1,6-dihydro-pyridazine-3-carboxylic acid methyl ester；4-Methyl-6-oxo-1-phenyl-1,6-dihydro-pyridazin-3-carbonsaeure-methylester
• CAS: 107516-97-2
• 化学式: C₁₃H₁₂N₂O₃
• 分子量: 244.25
• InChiKey: LRXORTVMUFISRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-methyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylic acid 在 氯化亚砜 作用下， 生成 methyl 4-methyl-6-oxo-1-phenylpyridazine-3-carboxylate
  参考文献：
  名称：

  Notes - 1-Phenyl-4-methyl-6-pyridazone-3-carboxylic Acid Derivatives

  摘要：

  DOI：

  10.1021/jo01108a613

文献信息

• [EN] SOS1 INHIBITOR AND USE THEREOF<br/>[FR] INHIBITEUR DE SOS1 ET SON UTILISATION<br/>[KO] SOS1 억제제 및 이의 용도
  申请人：KANAPH THERAPEUTICS INC

  公开号：WO2023022497A1

  公开（公告）日：2023-02-23

  화학식 I의 신규 화합물 및 이의 SOS1과 관련된 질환의 예방 또는 치료 용도를 제공한다. 본 발명의 일 양상의 신규 화합물은 SOS1와 RAS 패밀리 단백질 또는 SOS1과 RAC1의 상호작용을 저해함으로써 암 및 RAS 병증 등의 SOS1 매개된 질환의 예방 또는 치료에 유용하다.

  本发明提供了化学式I的新化合物及其用于预防或治疗与其SOS1相关的疾病。本发明的一方面的新化合物通过抑制SOS1和RAS家族蛋白或SOS1和RAC1之间的相互作用来预防或治疗SOS1介导的疾病，如癌症和RAS病变等，具有有用性。
• 2-Pyrones. XXII. β-Methylglutaconic Acid, β-Methylglutaconanilic Acids and Related Dianilides, Pyridones and Pyridazones
  作者：Richard H. Wiley、C. L. deSilva

  DOI：10.1021/ja01599a042

  日期：1956.9
• Reaction of Triethyl Phosphonoacetate Anion with Phenylhydrazones: A New Method for the Preparation of 3(2<i>H</i>)-Pyridazinones
  作者：Himatkumar V. Patel、Kavita A. Vyas、Sudhanshu P. Pandey、Francis Tavares、P. S. Fernandes

  DOI：10.1080/00397919108019791

  日期：1991.4

  Various 5,6-disubstituted-2-phenyl-3(2H)-pyridazinones 4 have been synthesised by reacting triethyl phosphonoacetate anion with monophenylhydrazone of 1,2-dicarbonyl compounds 2.
• A New and Convenient Synthesis of 3(2<i>H</i>)-Pyridazinones by Reacting Carbanion of Ethyl Trimethylsilylacetate with Phenylhydrazones
  作者：Himatkumar V. Patel、Kavita A. Vyas、Sudhanshu P. Pandey、Francis Tavares、P. S. Fernandes

  DOI：10.1080/00397919108021785

  日期：1991.9

  A one-pot synthesis of 5,6-disubstituted-2-phenyl-3(2H)-pyridazinones 4 is achieved on treatment of carbanion of ethyl trimethylsilylacetate with phenylhydrazones of 1,2-dicarbonyl compounds 1.
• PATEL, HIMATKUMAR V.;VYAS, KAVITA A.;PANDEY, SUDHANSHU P.;TAVARES, FRANCI+, SYNTH. COMMUN., 21,(1991) N-9, C. 1021-1026
  作者：PATEL, HIMATKUMAR V.、VYAS, KAVITA A.、PANDEY, SUDHANSHU P.、TAVARES, FRANCI+

  DOI：——

  日期：——