4-nitroso-4'-methoxydiphenylamine | 7696-66-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-nitroso-4'-methoxydiphenylamine
• 英文别名: N-(4-methoxyphenyl)-4-nitrosoaniline
• CAS: 7696-66-4
• 化学式: C₁₃H₁₂N₂O₂
• 分子量: 228.25
• InChiKey: QTJWGXNCAKOQSC-UHFFFAOYSA-N

物化性质

• 沸点：
  390.6±27.0 °C(Predicted)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-nitroso-4'-methoxydiphenylamine 在 ammonium sulfide 、 乙醚 、 sodium sulfate 、 silver(l) oxide 作用下， 生成 4-N-(4-methoxyphenyl)cyclohexa-2,5-diene-1,4-diimine
  参考文献：
  名称：

  Willstaetter; Kubli, Chemische Berichte, 1909, vol. 42, p. 4163

  摘要：

  DOI：
• 作为产物：
  描述：

  N-Nitroso-4-methoxy-diphenylamin 在 盐酸 、 乙醚 作用下， 生成 4-nitroso-4'-methoxydiphenylamine
  参考文献：
  名称：

  Willstaetter; Kubli, Chemische Berichte, 1909, vol. 42, p. 4163

  摘要：

  DOI：

文献信息

• Novel Imaging Agents for Detecting Neurological Dysfunction
  申请人：Kolb Hartmuth C.

  公开号：US20110046378A1

  公开（公告）日：2011-02-24

  Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease

  本文披露了一种诊断哺乳动物阿尔茨海默病或其易感性的化合物和方法，该方法包括向哺乳动物施用诊断有效量的放射性标记化合物，所述化合物选自放射性标记的黄酮类、香豆素类、咔唑类、喹啉酮类、香豆素酮类、咪唑类和三唑类衍生物组，使化合物分布到脑组织中，并成像脑组织，其中与正常结合水平相比，化合物与脑组织的结合增加表明该哺乳动物正在患有或有发展阿尔茨海默病的风险。
• p-Nitrosophenol chemistry. II. Amination of p-nitrosophenol ethers with primary aromatic amines
  作者：John T. Hays、Herbert Lewis Young、Herbert H. Espy

  DOI：10.1021/jo01277a039

  日期：1967.1
• Molecular-Level Insight into the Differential Oxidase and Oxygenase Reactivities of <i>de Novo</i> <i>Due Ferri</i> Proteins
  作者：Rae Ana Snyder、Susan E. Butch、Amanda J. Reig、William F. DeGrado、Edward I. Solomon

  DOI：10.1021/jacs.5b03524

  日期：2015.7.29

  Using the single-chain due ferri (DFsc) peptide scaffold, the differential oxidase and oxygenase reactivities of two 4A -> 4G variants, one with two histidines at the diiron center (G4DFsc) and the other with three histidines (3His-G4DFsc(Mut3)), are explored. By controlling the reaction conditions, the active form responsible for 4-aminophenol (4-AP) oxidase activity in both G4DFsc and 3His-G4DFsc(Mut3) is determined to be the substrate-bound biferrous site. Using circular dichroism (CD), magnetic CD (MCD), and variable-temperature, variable-field (VTVH) MCD spectroscopies, 4-AP is found to bind directly to the biferrous sites of the DF proteins. In G4DFsc, 4-AP increases the coordination of the biferrous site, while in 3His-G4DFsc(Mut3), the coordination number remains the same and the substrate likely replaces the additional bound histidine. This substrate binding enables a two-electron process where 4-AP is oxidized to benzoquinone imine and O-2 is reduced to H2O2. In contrast, only the biferrous 3His variant is found to be active in the oxygenation of p-anisidine to 4-nitroso-methoxybenzene. From CD, MCD, and VTVH MCD, p-anisidine addition is found to minimally perturb the biferrous centers of both G4DFsc and 3His-G4DFsc(Mut3), indicating that this substrate binds near the biferrous site. In 3His-G4DFsc(Mut3), the coordinative saturation of one iron leads to the two-electron reduction of O-2 at the second iron to generate an end-on hydroperoxo-Fe(III) active oxygenating species.
• Mizhiritskii, M. D.; Kuz'min, S. V.; Kogan, L. M., Journal of Organic Chemistry USSR (English Translation), 1989, vol. 25, # 6.2, p. 1204 - 1205
  作者：Mizhiritskii, M. D.、Kuz'min, S. V.、Kogan, L. M.

  DOI：——

  日期：——
• MIZHIRITSKIJ, M. D.;KUZMIN, S. V.;KOGAN, L. M., ZH. ORGAN. XIMII, 25,(1989) N, S. 1340-1341
  作者：MIZHIRITSKIJ, M. D.、KUZMIN, S. V.、KOGAN, L. M.

  DOI：——

  日期：——