N-[4-[2-(3,4-dimethoxyphenyl)ethyl]phenyl]-2-hydroxybenzamide | 110997-46-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-[2-(3,4-dimethoxyphenyl)ethyl]phenyl]-2-hydroxybenzamide
• 英文别名: N-{4-[2-(3,4-Dimethoxy-phenyl)-ethyl]-phenyl}-2-hydroxy-benzamide
• CAS: 110997-46-1
• 化学式: C₂₃H₂₃NO₄
• 分子量: 377.44
• InChiKey: MXPYFICRRZTDFE-UHFFFAOYSA-N

物化性质

• 沸点：
  470.6±45.0 °C(Predicted)
• 密度：
  1.224±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[4-[2-(3,4-dimethoxyphenyl)ethyl]phenyl]-2-hydroxybenzamide 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 N-[4-[2-(3,4-dihydroxyphenyl)ethyl]phenyl]-2-hydroxy-benzamide
  参考文献：
  名称：

  Catechol based inhibitors of 15-lipoxygenase

  摘要：

  A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15-lipoxygenase.

  DOI：

  10.1016/0960-894x(95)00565-b
• 作为产物：
  描述：

  2-(4-硝基苯基)乙酰氯 在 palladium on activated charcoal sodium hydroxide 、 三氯化铝 、 硫酸 、 氢气 、 溶剂黄146 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 N-[4-[2-(3,4-dimethoxyphenyl)ethyl]phenyl]-2-hydroxybenzamide
  参考文献：
  名称：

  Catechol based inhibitors of 15-lipoxygenase

  摘要：

  A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15-lipoxygenase.

  DOI：

  10.1016/0960-894x(95)00565-b

文献信息

• N-substituted-2-hydroxy-.alpha.-oxo-benzeneacetamides and pharmaceutical
  申请人：Warner-Lambert Company

  公开号：US04939133A1

  公开（公告）日：1990-07-03

  The present invention relates to novel N-substituted 2-hydroxybenzamide and N-substituted 2-hydroxy-.alpha.-oxo-benezene acetamide compounds pharmaceutical compositions, and methods of use for therefore for the treatment of diseases in which products having lipoxygenase enzyme activity contribute to the pathological condition. Selected novel intermediates are also the present invention.

  本发明涉及新型N-取代的2-羟基苯甲酰胺和N-取代的2-羟基-α-氧代苯乙酰胺化合物药物组合物，以及用于治疗病变中脂氧合酶酶活性产物导致病理状况的方法。所述发明还涉及选定的新型中间体。
• (N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0221346B1

  公开（公告）日：1991-01-30
• US4939133A
  申请人：——

  公开号：US4939133A

  公开（公告）日：1990-07-03
• Catechol based inhibitors of 15-lipoxygenase
  作者：Bradley D. Tait、Richard D. Dyer、Bruce J. Auerbach、Dirk Bornemeier、Linda Guilds-Zamarka、Maritza Oxender、Bruce D. Roth、Bharat K. Trivedi、Joseph A. Cornicelli

  DOI：10.1016/0960-894x(95)00565-b

  日期：1996.1

  A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15-lipoxygenase.