1,2,3-三溴戊烷 | 130156-60-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 中文名称: 1,2,3-三溴戊烷
• 英文名称: 1,2,3-tribromo-pentane
• 英文别名: 1,2,3-Tribrom-pentan；1,2,3-Tribromopentane
• CAS: 130156-60-4
• 化学式: C₅H₉Br₃
• 分子量: 308.838
• InChiKey: OXOSOLAWIOZHMF-UHFFFAOYSA-N

物化性质

• 沸点：
  122-124 °C(Press: 14 Torr)
• 密度：
  2.0714 g/cm3(Temp: 19 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,2,3-三溴戊烷 在 氢氧化钾 、 乙醚 作用下， 生成 (Z)-3-bromo-3-hexene
  参考文献：
  名称：

  Lespieau; Wiemann, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1929, vol. 188, p. 999

  摘要：

  DOI：
• 作为产物：
  描述：

  1-戊烯-3-醇 在 吡啶 、 溴 、 三溴化磷 作用下， 生成 1,2,3-三溴戊烷
  参考文献：
  名称：

  Membrane currents in cultured human intestinal smooth muscle cells

  摘要：

  1. Using whole-cell patch-clamp recording techniques, we have examined voltage-gated ion currents in a cultured human intestinal smooth muscle cell line (HISM). Experiments were performed at room temperature on cells after passages 16 and 17.2. Two major components of the whole-cell current were a tetraethylammonium-sensitive (IC50 = 9 mM), iberiotoxin-resistant, delayed rectifier K+ current and a Na+ current inhibited by tetrodotoxin (IC50 approximate to 100 nM). No measurable inward current via voltage-gated Ca2+ channels could be detected in these cells even with 10 mM Ca2+ or Ba2+ in the external solution. No current attributable to calcium-activated K+ channels was found and no cationic current in response to muscarinic receptor activation was present.3. In divalent cation-free external solution two additional currents were activated: an inwardly rectifying hyperpolarization-activated current, I-HA, and a depolarization-activated current, I-DA.4. I-HA and I-DA could be carried by several monovalent cations; the sizes of currents in descending order were: K+ > Cs+ > Na+ for I-HA and Na+ > K+ much greater than Cs+ for I-DA. I-HA was activated and deactivated instantaneously and showed no inactivation whereas I-DA was activated, inactivated and deactivated within tens of milliseconds. These currents were inhibited by external calcium with an IC50 of 0.3 muM for I-DA and an IC50 of 20 muM for I-HA5. Cyclopiazonic acid (CPA) induced an outward, but not an inward current. SK&F 96365, a blocker of store-operated Ca2+ channels, suppressed I-DA With a. half-maximal inhibitory concentration of 9 muM but was ineffective in inhibiting I-HA at concentrations up to 100 muM. Gd3+ and La3+ strongly suppressed I-DA at 1 and 10 muM, respectively and were less effective in blocking I-HA (complete inhibition required a concentration of 100 muM for both). Carbachol at 10-100 muM evoked about a S-fold increase in I-HA amplitude and completely abolished I-DA.6. We conclude that I-HA and I-DA, are Ca2+-blockable cationic currents with different ion selectivity profiles that are carried by different channels. I-DA shows novel voltage-dependent properties for a cationic current.

  DOI：

  10.1111/j.1469-7793.2000.00521.x

文献信息

• Lespieau; Wiemann, Bulletin de la Societe Chimique de France, 1929, vol. <4>45, p. 628
  作者：Lespieau、Wiemann

  DOI：——

  日期：——
• Bouis, Annales de Chimie (Cachan, France), 1928, vol. <10>9, p. 420
  作者：Bouis

  DOI：——

  日期：——
• Delaby, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1923, vol. 176, p. 590
  作者：Delaby

  DOI：——

  日期：——
• Tschadaewa; Kamai, Zhurnal Obshchei Khimii, 1950, vol. 20, p. 1487,1491;engl.Ausg.S.1549,1553
  作者：Tschadaewa、Kamai

  DOI：——

  日期：——
• Membrane currents in cultured human intestinal smooth muscle cells
  作者：A. V. Zholos、C. J. Fenech、S. A. Prestwich、T. B. Bolton

  DOI：10.1111/j.1469-7793.2000.00521.x

  日期：2000.11

  1. Using whole-cell patch-clamp recording techniques, we have examined voltage-gated ion currents in a cultured human intestinal smooth muscle cell line (HISM). Experiments were performed at room temperature on cells after passages 16 and 17.2. Two major components of the whole-cell current were a tetraethylammonium-sensitive (IC50 = 9 mM), iberiotoxin-resistant, delayed rectifier K+ current and a Na+ current inhibited by tetrodotoxin (IC50 approximate to 100 nM). No measurable inward current via voltage-gated Ca2+ channels could be detected in these cells even with 10 mM Ca2+ or Ba2+ in the external solution. No current attributable to calcium-activated K+ channels was found and no cationic current in response to muscarinic receptor activation was present.3. In divalent cation-free external solution two additional currents were activated: an inwardly rectifying hyperpolarization-activated current, I-HA, and a depolarization-activated current, I-DA.4. I-HA and I-DA could be carried by several monovalent cations; the sizes of currents in descending order were: K+ > Cs+ > Na+ for I-HA and Na+ > K+ much greater than Cs+ for I-DA. I-HA was activated and deactivated instantaneously and showed no inactivation whereas I-DA was activated, inactivated and deactivated within tens of milliseconds. These currents were inhibited by external calcium with an IC50 of 0.3 muM for I-DA and an IC50 of 20 muM for I-HA5. Cyclopiazonic acid (CPA) induced an outward, but not an inward current. SK&F 96365, a blocker of store-operated Ca2+ channels, suppressed I-DA With a. half-maximal inhibitory concentration of 9 muM but was ineffective in inhibiting I-HA at concentrations up to 100 muM. Gd3+ and La3+ strongly suppressed I-DA at 1 and 10 muM, respectively and were less effective in blocking I-HA (complete inhibition required a concentration of 100 muM for both). Carbachol at 10-100 muM evoked about a S-fold increase in I-HA amplitude and completely abolished I-DA.6. We conclude that I-HA and I-DA, are Ca2+-blockable cationic currents with different ion selectivity profiles that are carried by different channels. I-DA shows novel voltage-dependent properties for a cationic current.