4-nitro-N-pyridin-3-yl-benzenesulfonamide | 326901-73-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-nitro-N-pyridin-3-yl-benzenesulfonamide
• 英文别名: 4-nitrobenzenesulfonamide-N-3-pyridinyl；4-nitro-N-(pyridin-3-yl)benzenesulfonamide；4-nitro-N-pyridin-3-ylbenzenesulfonamide
• CAS: 326901-73-9
• 化学式: C₁₁H₉N₃O₄S
• 分子量: 279.276
• InChiKey: CZRISBMGZLRLED-UHFFFAOYSA-N

物化性质

• 沸点：
  489.2±51.0 °C(Predicted)
• 密度：
  1.520±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-nitro-N-pyridin-3-yl-benzenesulfonamide 在 palladium on activated charcoal 吡啶 、 氢气 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 生成 N-Acetyl-4-amino-N-pyridin-3-yl-benzenesulfonamide
  参考文献：
  名称：

  Vampa; Pecorari; Albasini, Farmaco, Edizione Scientifica, 1982, vol. 37, # 10, p. 701 - 710

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氨基吡啶 、 对硝基苯磺酰氯 在 4-二甲氨基吡啶 三乙胺 、 sodium methylate 、 盐酸 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 4.0h， 以85%的产率得到4-nitro-N-pyridin-3-yl-benzenesulfonamide
  参考文献：
  名称：

  WO2007/118137

  摘要：

  公开号：

文献信息

• Inhibitors of Histone Deacetylase
  申请人：Delorme Daniel

  公开号：US20070213330A1

  公开（公告）日：2007-09-13

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制组蛋白去乙酰化酶的技术。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病况的组合物和方法。
• Inhibitors of histone deacetylase
  申请人：Moradei Oscar

  公开号：US08598168B2

  公开（公告）日：2013-12-03

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制组蛋白去乙酰化酶的技术。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。
• In vivo and in vitro anti-leishmanial activities of 4-nitro-N-pyrimidin- and N-pyrazin-2-ylbenzenesulfonamides, and N2-(4-nitrophenyl)-N1-propylglycinamide
  作者：M. Auxiliadora Dea-Ayuela、Encarna Castillo、Marta Gonzalez-Alvarez、Celeste Vega、Miriam Rolón、Francisco Bolás-Fernández、Joaquín Borrás、M. Eugenia González-Rosende

  DOI：10.1016/j.bmc.2009.09.030

  日期：2009.11

  A series of compounds containing the nitrobenzene and sulfonamido moieties were synthesized and their leishmanicidal effect was assessed in vitro against Leishmania infantum promastigotes. Among the compounds evaluated, the p-nitrobenzenesulfonamides 4Aa and 4Ba, and the p-nitroaniline 5 showed significant activity with a good selectivity index. In a Balb/c mice model of L. Infantum, administration of compounds 4Aa, 4Ba or 5 (5 mg/kg/day for 10 days, injected ip route) led to a clear-cut parasite burden reduction (ca. 99%). In an attempt to elucidate their mechanism of action, the DNA interaction of 4Aa and 5 was investigated by means of viscosity studies, thermal denaturation and nuclease activity assay. Both compounds showed nuclease activity in the presence of copper salt. The results suggest that compounds 4Aa, 4Ba and 5 represent possible candidates for drug development in the therapeutic control of leishmaniasis. (C) 2009 Elsevier Ltd. All rights reserved.
• Cross coupling of 3-bromopyridine and sulfonamides (R1NHSO2R2·R1=H, Me, alkyl; R2=alkyl and aryl) catalyzed by CuI/1,3-di(pyridin-2-yl)propane-1,3-dione
  作者：Xiaojun Han

  DOI：10.1016/j.tetlet.2009.11.037

  日期：2010.1

  N-(3-Pyridinyl)-substituted secondary and tertiary sulfonamides have been synthesized in good to excellent yields by the reaction of 3-bromopyridine with primary and secondary alkyl and aryl sulfonamides (MeSO2NH2, MeSO2NHMe, TolSO(2)NH(2), TolSO(2)NHMe, 1,3-propanesultam, and 1,4-butanesultam), catalyzed by CuI (20 mol %) and 1,3-di(pyridin-2-yl)propane-1,3-dione (20 mol %) with K2CO3 (200 mol %) in DMF (0.17 M for ArBr) at 110-120 degrees C over 36-40 h. 2-Bromopyridine, 4-bromopyridine, and a wide variety of substituted phenyl bromides can also be successfully coupled with sulfonamides under these reaction conditions. (C) 2009 Elsevier Ltd. All rights reserved.
• INHIBITORS OF HISTONE DEACETYLASE
  申请人：MethylGene Inc.

  公开号：EP1735319B1

  公开（公告）日：2017-05-03