(S)-Cbz-L-Phe-NHEt | 17186-48-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-Cbz-L-Phe-NHEt
• 英文别名: N-Benzyloxycarbonyl-L-phenylalanin-aethylamid；N-Benzyloxycarbonyl-L-phenylalanin-ethylamid；benzyl N-[(2S)-1-(ethylamino)-1-oxo-3-phenylpropan-2-yl]carbamate
• CAS: 17186-48-0
• 化学式: C₁₉H₂₂N₂O₃
• 分子量: 326.395
• InChiKey: DWZHXUNRCNVFJE-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-苄氧羰基-L-苯丙氨酸 、 乙胺盐酸盐 在 氯甲酸乙酯 、 三乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.0h， 以87%的产率得到(S)-Cbz-L-Phe-NHEt
  参考文献：
  名称：

  Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1 S ,2 R )-tranylcypromine

  摘要：

  Primary amidations of carboxylic acids 1 or 3 with NH4Cl in the presence of ClCO2Et and Et3N were developed to afford the corresponding primary amides in 22% to quantitative yields. Additionally, we have applied the amidation to the preparation of various amides containing hydroxamic acids and achieved the synthesis of (1S,2R)-tranylcypromine as an antidepressant medicine via Lossen rearrangement. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2017.10.015

文献信息

• [EN] FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS<br/>[FR] MODULATEURS À RÉGLAGE FIN DE L'EXCITABILITÉ NEURONALE POUR DES TROUBLES NEUROPSYCHIATRIQUES
  申请人：UNIV TEXAS

  公开号：WO2018094335A1

  公开（公告）日：2018-05-24

  The present invention relates to novel small molecule modulators of Nav1.6 channels of the general formulae (I), (II), (III) and (IV), and the uses thereof.

  本发明涉及一种新型小分子调节剂，其通式为(I)、(II)、(III)和(IV)，以及其用途。
• Treatment compositions
  申请人：The Procter & Gamble Company

  公开号：US10689600B2

  公开（公告）日：2020-06-23

  The present invention relates to treatment compositions containing one or more polymers, cationic scavenging agent and an optional structurant as well as methods of making and using same. Such treatment compositions provide stability and benefit agent deposition. Such treatment compositions may be used, for example, as through the wash and/or through the rinse fabric enhancers as well as unit dose treatment compositions.

  本发明涉及含有一种或多种聚合物、阳离子清除剂和任选结构剂的处理组合物，以及制造和使用这些组合物的方法。这种处理组合物具有稳定性并有利于药剂沉积。例如，这种处理组合物可用作水洗和/或漂洗织物增强剂以及单位剂量处理组合物。
• CLEANING COMPOSITIONS CONTAINING A POLYETHERAMINE
  申请人：The Procter & Gamble Company

  公开号：US20170121642A1

  公开（公告）日：2017-05-04

  The present invention relates generally to cleaning compositions and, more specifically, to cleaning compositions containing a polyetheramine that is suitable for removal of stains from soiled materials.
• TREATMENT COMPOSITIONS
  申请人：The Procter & Gamble Company

  公开号：US20170211018A1

  公开（公告）日：2017-07-27

  The present invention relates to treatment compositions containing one or more polymers, cationic scavenging agent and an optional structurant as well as methods of making and using same. Such treatment compositions provide stability and benefit agent deposition. Such treatment compositions may be used, for example, as through the wash and/or through the rinse fabric enhancers as well as unit dose treatment compositions.
• Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1 S ,2 R )-tranylcypromine
  作者：Tetsuya Ezawa、Yuya Kawashima、Takuya Noguchi、Seunghee Jung、Nobuyuki Imai

  DOI：10.1016/j.tetasy.2017.10.015

  日期：2017.12

  Primary amidations of carboxylic acids 1 or 3 with NH4Cl in the presence of ClCO2Et and Et3N were developed to afford the corresponding primary amides in 22% to quantitative yields. Additionally, we have applied the amidation to the preparation of various amides containing hydroxamic acids and achieved the synthesis of (1S,2R)-tranylcypromine as an antidepressant medicine via Lossen rearrangement. (C) 2017 Elsevier Ltd. All rights reserved.