dimethyl 2,6-dihydroxy-4-isopropylimino-2,6-bis(trifluoromethyl)heptanedioate | 1241859-77-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: dimethyl 2,6-dihydroxy-4-isopropylimino-2,6-bis(trifluoromethyl)heptanedioate
• 英文别名: Dimethyl 2,6-dihydroxy-4-propan-2-ylimino-2,6-bis(trifluoromethyl)heptanedioate
• CAS: 1241859-77-7
• 化学式: C₁₄H₁₉F₆NO₆
• 分子量: 411.298
• InChiKey: GHUJTUFKBOPUFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  dimethyl 2,6-dihydroxy-4-isopropylimino-2,6-bis(trifluoromethyl)heptanedioate 在 盐酸 、 水 作用下， 以 丙酮 为溶剂， 反应 2.0h， 以74%的产率得到dimethyl 2,6-dihydroxy-4-oxo-2,6-bis(trifluoromethyl)heptanedioate
  参考文献：
  名称：

  Facile synthetic pathway to β-hydroxy-β-trifluoromethyl imines and their derivatives

  摘要：

  Synthetic approach based on mediated addition of different trifluoromethylated building blocks to selected acyclic imines giving access to a variety of beta-hydroxy-beta-trifluoromethyl imines are elaborated. A reaction between fluorinated adducts and imines proceed easily giving the condensation products in good to excellent yields. beta-Hydroxy-beta-trifluoromethyl imines possessing trifluoromethyl group and exhibiting strong intramolecular hydrogen bonding are great precursors to different beta-hydroxy-beta-trifluoromethyl ketones and alcohols. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2009.12.005
• 作为产物：
  描述：

  三氟丙酮酸甲酯 、 N-丙-2-基丙-2-亚胺 以 乙醚 为溶剂， 反应 10.0h， 以94%的产率得到dimethyl 2,6-dihydroxy-4-isopropylimino-2,6-bis(trifluoromethyl)heptanedioate
  参考文献：
  名称：

  Facile synthetic pathway to β-hydroxy-β-trifluoromethyl imines and their derivatives

  摘要：

  Synthetic approach based on mediated addition of different trifluoromethylated building blocks to selected acyclic imines giving access to a variety of beta-hydroxy-beta-trifluoromethyl imines are elaborated. A reaction between fluorinated adducts and imines proceed easily giving the condensation products in good to excellent yields. beta-Hydroxy-beta-trifluoromethyl imines possessing trifluoromethyl group and exhibiting strong intramolecular hydrogen bonding are great precursors to different beta-hydroxy-beta-trifluoromethyl ketones and alcohols. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2009.12.005

文献信息

• Facile synthetic pathway to β-hydroxy-β-trifluoromethyl imines and their derivatives
  作者：Ildikó Loop、Hanna Skarpos、Nataliya Kalinovich、Olesya Kazakova、Enno Lork、Gerd-Volker Röschenthaler

  DOI：10.1016/j.jfluchem.2009.12.005

  日期：2010.3

  Synthetic approach based on mediated addition of different trifluoromethylated building blocks to selected acyclic imines giving access to a variety of beta-hydroxy-beta-trifluoromethyl imines are elaborated. A reaction between fluorinated adducts and imines proceed easily giving the condensation products in good to excellent yields. beta-Hydroxy-beta-trifluoromethyl imines possessing trifluoromethyl group and exhibiting strong intramolecular hydrogen bonding are great precursors to different beta-hydroxy-beta-trifluoromethyl ketones and alcohols. (C) 2009 Elsevier B.V. All rights reserved.