DL-N-Isobutyl-serin | 2361-84-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DL-N-Isobutyl-serin
• 英文别名: 3-Hydroxy-2-(2-methylpropylamino)propanoic acid；3-hydroxy-2-(2-methylpropylamino)propanoic acid
• CAS: 2361-84-4
• 化学式: C₇H₁₅NO₃
• 分子量: 161.201
• InChiKey: ZENVPUAZDQMYIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙基亚基三乙酸酯 、 氰化钾 、 异丁胺盐酸盐 生成 DL-N-Isobutyl-serin
  参考文献：
  名称：

  Geipel,H. et al., Chemische Berichte, 1965, vol. 98, p. 1677 - 1680

  摘要：

  DOI：

文献信息

• Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application
  申请人：GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

  公开号：US11384048B2

  公开（公告）日：2022-07-12

  Disclosed in the present invention are an aromatic vinyl or aromatic ethyl derivative, a preparation method therefor, an intermediate, a pharmaceutical composition, and an application. The aromatic vinyl or aromatic ethyl derivative in the present invention is as represented by general formula (I). The aromatic vinyl or aromatic ethyl derivative in the present invention has an obvious inhibitory effect on PD-1/PD-L1, is a very effective small-molecule PD-1/PD-L1 inhibitor, and can effectively alleviate or treat relevant diseases such as cancer.

  本发明公开了一种芳香族乙烯基或芳香族乙基衍生物、其制备方法、中间体、药物组合物和应用。本发明中的芳香族乙烯基或芳香族乙基衍生物由通式（I）表示。本发明中的芳香族乙烯基或芳香族乙基衍生物对PD-1/PD-L1具有明显的抑制作用，是一种非常有效的小分子PD-1/PD-L1抑制剂，可以有效缓解或治疗癌症等相关疾病。
• AROMATIC VINYL OR AROMATIC ETHYL DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE, PHARMACEUTICAL COMPOSITION, AND APPLICATION
  申请人：GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

  公开号：US20210061755A1

  公开（公告）日：2021-03-04

  Disclosed in the present invention are an aromatic vinyl or aromatic ethyl derivative, a preparation method therefor, an intermediate, a pharmaceutical composition, and an application. The aromatic vinyl or aromatic ethyl derivative in the present invention is as represented by general formula (I). The aromatic vinyl or aromatic ethyl derivative in the present invention has an obvious inhibitory effect on PD-1/PD-L1, is a very effective small-molecule PD-1/PD-L1 inhibitor, and can effectively alleviate or treat relevant diseases such as cancer.
• Geipel,H. et al., Chemische Berichte, 1965, vol. 98, p. 1677 - 1680
  作者：Geipel,H. et al.

  DOI：——

  日期：——