3-methoxy-2,2'-bipyridyl | 93560-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-methoxy-2,2'-bipyridyl
• 英文别名: 3-Methoxy-2,2'-bipyridin；3-Methoxy-2,2'-bipyridine；3-methoxy-2-pyridin-2-ylpyridine
• CAS: 93560-61-3
• 化学式: C₁₁H₁₀N₂O
• 分子量: 186.213
• InChiKey: UGLNIOPFUJXMGS-UHFFFAOYSA-N

物化性质

• 沸点：
  286.4±25.0 °C(Predicted)
• 密度：
  1.127±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-methoxy-2,2'-bipyridyl 在 盐酸 作用下， 反应 12.0h， 以70%的产率得到[2,2'-bipyridyl]-3-ol
  参考文献：
  名称：

  Kaczmarek, Lukasz; Balicki, Roman; Lipkowski, Janusz, Journal of the Chemical Society. Perkin transactions II, 1994, # 7, p. 1603 - 1610

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(2-呋喃甲酰基)吡啶 在 乙酸铵 、 sodium methylate 作用下， 反应 2.0h， 生成 3-methoxy-2,2'-bipyridyl
  参考文献：
  名称：

  Siemanowski, Werner; Witzel, Herbert, Liebigs Annalen der Chemie, 1984, # 10, p. 1731 - 1739

  摘要：

  DOI：

文献信息

• SIEMANOWSKI, W.;WITZEL, H., LIEBIGS ANN. CHEM., 1984, N 10, 1731-1739
  作者：SIEMANOWSKI, W.、WITZEL, H.

  DOI：——

  日期：——
• A PROCESS FOR THE PREPARATION OF COPOLYMERS
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0877772A1

  公开（公告）日：1998-11-18
• [EN] A PROCESS FOR THE PREPARATION OF COPOLYMERS<br/>[FR] PROCEDE DE PREPARATION DE COPOLYMERES
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：WO1997028206A1

  公开（公告）日：1997-08-07

  (EN) A process for the preparation of a copolymer of carbon monoxide with an olefinically unsaturated compound, comprising copolymerizing the monomers in the presence of a Group VIII metal containing catalyst composition and in the presence of an olefinically unsaturated compound (A) which contains in its molecular structure an organic group imparting steric hindrance on the vinyl group. A copolymer obtainable by the said process.(FR) Ce procédé de préparation d'un copolymère de monoxyde de carbone et d'un composé alcénique consiste à copolymériser les monomères en présence, d'une part, d'une composition de catalyseur contenant un métal du groupe VIII et, d'autre part, d'un composé (A) alcénique comprenant dans sa structure moléculaire un groupe organique transmettant l'empêchement stérique au groupe vinyle. On décrit également le copolymère obtenu à l'aide dudit procédé.
• [EN] CHEMICAL LIBRARIES USEFUL FOR DRUG DISCOVERY PROCESSES<br/>[FR] BIBLIOTHEQUES CHIMIQUES UTILES AUX PROCEDES DE DECOUVERTES DE MEDICAMENTS
  申请人：7TM PHARMA AS

  公开号：WO2003003008A1

  公开（公告）日：2003-01-09

  Use of chemical compounds or selections of chemical compounds (libraries) of the general formula (I): for in vivo methods for testing or validating the physiological importance and/or the therapeutic or pharmacological potential of biological target molecules, notably proteins such as, e.g., receptors and especially 7TM receptors in test animals expressing the biological target molecule with, notably, a silent, engineered metal-ion site. Use of specific metal-ion binding sites of a generic nature in specific biological target molecules such as, e.g. transmembrane proteins wherein the metal-ion binding site is capable of forming a complex with a metal ion is also described. Chemical compounds or libraries suitable for use in methods for improving the in vivo pharmacokinetic behaviour of metal-ion chelates (e.g. the absorption pattern, the plasma half-life, the distribution, the metabolism and/or the elimination of the metal-ion chelates). In order to improve the efficacy of the metal-ion chelates impact on the biological target molecule after administration of the metal-ion chelate in vivo to a test animal it is advantageous e.g. to increase the time period during which the metal-ion chelate is in the circulatory system and/or localised at the target. Metal-ion chelating compounds, which are designed to be suitable for use in a target validation process according to the invention and to libraries of at least two or more of such metal-ion chelating compounds are disclosed.
• [EN] USE OF METAL-ION CHELATES IN VALIDATING BIOLOGICAL MOLECULES AS DRUG TARGETS IN TEST ANIMAL MODELS<br/>[FR] UTILISATION DE CHELATES A IONS METALLIQUES DANS LA VALIDATION DE MOLECULES BIOLOGIQUES UTILISEES COMME CIBLES MEDICAMENTEUSES DANS DES MODELES ANIMAUX EXPERIMENTAUX
  申请人：7TM PHARMA AS

  公开号：WO2003003009A1

  公开（公告）日：2003-01-09

  Use of chemical compounds or selections of chemical compounds (libraries) of the general Formula (I): for in vivo methods for testing or validating the physiological importance and/or the therapeutic or pharmacological potential of biological target molecules, notably proteins such as, e.g., receptors and especially 7TM receptors in test animals expressing the biological target molecule with, notably, a silent, engineered metal-ion site. Use of specific metal-ion binding sites of a generic nature in specific biological target molecules such as, e.g. transmembrane proteins wherein the metal-ion binding site is capable of forming a complex with a metal ion is also described. Chemical compounds or libraries suitable for use in methods for improving the in vivo pharmacokinetic behaviour of metal-ion chelates (e.g. the absorption pattern, the plasma half-life, the distribution, the metabolism and/or the elimination of the metal-ion chelates). In order to improve the efficacy of the metal-ion chelates impact on the biological target molecule after administration of the metal-ion chelate in vivo to a test animal it is advantageous e.g. to increase the time period during which the metal-ion chelate is in the circulatory system and/or localised at the target. Metal-ion chelating compounds, which are designed to be suitable for use in a target validation process according to the invention and to libraries of at least two or more of such metal-ion chelating compounds are disclosed.