(4-(2-bromoethoxy)-2-hydroxy)benzophenone | 18902-63-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-(2-bromoethoxy)-2-hydroxy)benzophenone
• 英文别名: 4-(2-bromoethoxy)-2-hydroxybenzophenone；4-(β-Brom-ethoxy-)-2-hydroxy-benzophenon；2-Hydroxy-4-(β-bromethoxy)benzophenon；[4-(2-bromoethoxy)-2-hydroxyphenyl]-phenylmethanone
• CAS: 18902-63-1
• 化学式: C₁₅H₁₃BrO₃
• 分子量: 321.17
• InChiKey: OWNKEEWPSSOZJO-UHFFFAOYSA-N

物化性质

• 熔点：
  90–95°C
• 沸点：
  440.9±40.0 °C(Predicted)
• 密度：
  1.462±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  十二氟庚醇 、 (4-(2-bromoethoxy)-2-hydroxy)benzophenone 在 sodium hydride 作用下， 以 丙酮 为溶剂， 反应 0.5h， 以58.29%的产率得到(4-(2-(2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctyloxy)ethoxy)-2-hydroxy)benzophenone
  参考文献：
  名称：

  Ultraviolet light absorber with low surface energy: synthesis and characterization

  摘要：

  Novel fluorine-containing ultraviolet absorbers (FBPs) with low surface energy were successfully synthesized based on 2,4-dihydroxy benzophenone (BP-1), and their structures were characterized by H-1 NMR,C-13 NMR, FTIR, and HRMS. UV absorption of FBPs was studied in 10(-4) M dichloromethane (CH2Cl2), which demonstrated the superior UV absorption capability of FBPs (ca. epsilon=1.7 x 10(4) to 2.2 x 10(4) at lambda(max)) over the matrix (epsilon=1.7 x 10(4) at lambda(max)). Quantum chemistry calculation was performed to investigate the stable structure and UV electronic absorption bands of FBPs. The surface chemistry information of high-chlorinated polyethylene (HCPE) coating films embedded with ultraviolet absorbers (UVAs) was given by X-ray photoelectron spectroscopy (XPS) and contact angle measurement. The results show that the surface enrichment capability of FBPs is remarkably better than traditional UVAs (including BP-1, BP-3, BP-12) because of the low surface energy properties of FBPs. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.07.008
• 作为产物：
  描述：

  2,4-二羟二苯甲酮 、 1,2-二溴乙烷 在 sodium hydroxide 、 sodium carbonate 作用下， 以 乙醇 、 水 、 丙酮 为溶剂， 以55.3 g (0.17 mol, 43%)的产率得到(4-(2-bromoethoxy)-2-hydroxy)benzophenone
  参考文献：
  名称：

  Novel sunscreen agents, sunscreen compositions and methods for

  摘要：

  本发明涉及一种新型防晒剂，具有吸收UVA和UVB波长辐射的能力。防晒剂包括一种特定类型的吸收UVA的色团和一种特定类型的吸收UVB的色团共价结合在一起。这些色团基团通过共价键结合在一起，使得这些基团的电子系统没有直接耦合。本发明还涉及含有上述类型防晒剂的防晒组合物。此外，本发明涉及一种方法，用于保护人类或低等动物的皮肤免受UVA和UVB波长辐射的影响。该方法包括局部涂抹本发明的防晒组合物，形成有效的涂层。

  公开号：

  US04999186A1

文献信息

• Derivatives of 2,4-dihydroxybenzophenone. Part I
  作者：Frank S. H. Head

  DOI：10.1039/j39690000034

  日期：——

  Several 4-(β-aryloxyethyl), 4-(β-aryloxyethoxymethyl and 4-[β-(aryloxymethoxy)ethyl] ethers of 2,4-dihydroxy-benzophenone are reported; such are frequently dimorphic. An easy preparation of 4-hydroxy-2-methoxy-benzophenone is described.

  据报道有几种2,4-二羟基二苯甲酮的4-（β-芳氧基乙基），4-（β-芳氧基乙氧基甲基）和4- [β-（芳氧基甲氧基）乙基]醚；它们经常是二态的，易于制备4-羟基描述了-2-甲氧基-二苯甲酮。
• Multichromophoric benzotriazole ultraviolet stabilizers
  申请人：Eastman Kodak Company

  公开号：US03981884A1

  公开（公告）日：1976-09-21

  The invention relates to multichromophoric compounds which have been found to be effective ultraviolet stabilizers. The invention also relates to ultraviolet degradable organic compositions containing a stabilizing amount of the multichromophoric composition to prevent such degradation. These stabilizers are effective in the presence of other additives commonly employed in polymeric compositions including, for example, pigments, colorants, fillers, reinforcing agents and the like. These ultraviolet stabilizers may also be incorporated into the organic compositions in the polymer melt or dissolved in the polymer dope, coated on the exterior of the molded article, film or extruded fiber.

  本发明涉及多色团化合物，已发现其是有效的紫外线稳定剂。本发明还涉及含有稳定剂量的多色团化合物的紫外降解有机组成物，以防止这种降解。这些稳定剂在聚合物组成中常用的其他添加剂存在的情况下是有效的，包括例如颜料、染料、填充剂、增强剂等。这些紫外线稳定剂也可以在聚合物熔融中或溶解在聚合物溶液中被纳入有机组成物中，涂覆在成型物、薄膜或挤出纤维的外表面上。
• Sunscreen agents, sunscreen compositions and methods for preventing
  申请人：The Procter & Gamble Company

  公开号：US05160731A1

  公开（公告）日：1992-11-03

  The present invention relates to novel sunscreen agents which have the ability to absorb both UVA and UVB wavelength radiation. The sunscreen agents comprise a specific type of UVA-absorbing chromophore covalently bonded to a specific type of UVB-absorbing chromophore. The chromophore moieties are covalently bonded together such that the electron systems of these moieties are not directly coupled. The present invention further relates to sunscreen compositions containing the hereinbefore described type of sunscreen agents. Furthermore, the present invention relates to methods for protecting the skin of humans of lower animals from the effects of UVA and UVB wavelength radiation. This method comprises topically applying to the skin an effective coating of a sunscreen composition of the present invention.

  本发明涉及一种新型防晒剂，具有吸收UVA和UVB波长辐射的能力。该防晒剂包含一种特定类型的UVA吸收色团，与一种特定类型的UVB吸收色团共价键合。这些色团基团是共价键结合在一起的，使得这些基团的电子系统没有直接耦合。本发明还涉及含有上述类型的防晒剂的防晒组合物。此外，本发明还涉及一种保护人类或低等动物皮肤免受UVA和UVB波长辐射影响的方法。该方法包括将本发明的防晒组合物有效涂布于皮肤上。
• Sunscreen agents, sunscreen compositions and method for preventing
  申请人：The Procter & Gamble Company

  公开号：US05229106A1

  公开（公告）日：1993-07-20

  The present invention relates to novel sunscreen agents which have the ability to absorb both UVA and UVB wavelength radiation. The sunscreen agents comprise a specific type of UVA-absorbing chromophore covalently bonded to a specific type of UVB-absorbing chromophore. The chromophore moieties are covalently bonded together such that the electron systems of these moieties are not directly coupled. The present invention further relates to sunscreen compositions containing the hereinbefore described type of sunscreen agents. Furthermore, the present invention relates to methods for protecting the skin of humans or lower animals from the effects of UVA and UVB wavelength radiation. This method comprises topically applying to the skin an effective coating of a sunscreen composition of the present invention.

  本发明涉及一种新型防晒剂，具有吸收UVA和UVB波长辐射的能力。防晒剂包括一种特定类型的UVA吸收色团，与一种特定类型的UVB吸收色团共价键合。这些色团基团是共价键合在一起的，使得这些基团的电子系统没有直接耦合。本发明还涉及含有上述类型防晒剂的防晒组合物。此外，本发明还涉及一种保护人类或低等动物皮肤免受UVA和UVB波长辐射影响的方法。该方法包括将本发明的防晒组合物有效涂覆于皮肤表面。
• Multichromophoric ultraviolet stabilizers and their use in organic
  申请人：Eastman Kodak Company

  公开号：US04256626A1

  公开（公告）日：1981-03-17

  The invention relates to multichromophoric compounds which have been found to be effective ultraviolet stabilizers. The invention also relates to ultraviolet degradable organic compositions containing a stabilizing amount of the multichromophoric composition to prevent such degradation. These stabilizers are effective in the presence of other additives commonly employed in polymeric compositions including, for example, pigments, colorants, fillers, reinforcing agents and the like. These ultraviolet stablizers may also be incorporated into the organic compositions in the polymer melt or dissolved in the polymer dope, coated on the exterior of the molded article, film or extruded fiber.

  本发明涉及一种多色团化合物，已发现其具有有效的紫外线稳定剂作用。本发明还涉及含有多色团化合物稳定剂量的紫外线可降解有机组成物，以防止这种降解。这些稳定剂在聚合物组成物中存在其他常用添加剂的情况下具有有效性，包括颜料、染料、填料、增强剂等。这些紫外线稳定剂也可以在聚合物熔融中或溶解在聚合物溶液中被纳入有机组成物中，涂覆在成型件、薄膜或挤出纤维的外部。