γ-glutamyl-glutamic acid | 6729-93-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: γ-glutamyl-glutamic acid
• 英文别名: N-γ-glutamyl-glutamic acid；N-γ-Glutamyl-glutaminsaeure；γ-glutamylglutamic acid；γ-Glutamyl-glutaminsaeure；L-gamma-glutamyl-L-glutamic acid；2-[(4-amino-4-carboxybutanoyl)amino]pentanedioic acid
• CAS: 6729-93-7；6931-86-8；178180-38-6
• 化学式: C₁₀H₁₆N₂O₇
• 分子量: 276.246
• InChiKey: OWQDWQKWSLFFFR-UHFFFAOYSA-N

物化性质

• 沸点：
  664.1±55.0 °C(Predicted)
• 密度：
  1.470±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  167
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  月桂酰氯 、 γ-glutamyl-glutamic acid 在 盐酸 作用下， 以 27-% sodium hydroxide 、 水 、 丙酮 为溶剂， 以89%的产率得到N-(N'-lauroyl-γ-glutamyl)glutamic acid
  参考文献：
  名称：

  Cleaning compositions containing acylated dipeptides and acylated amino

  摘要：

  一种清洁组合物，包含一种N-长链酰化二肽和一种N-长链酰化酸性氨基酸。该清洁组合物具有低皮肤刺激性，对硬水具有良好的抗性，不会出现混浊和一些天然肽所带来的不愉快气味。该组合物在使用过程中和使用后也提供了优异的皮肤和头发感受质量。

  公开号：

  US05854199A1

文献信息

• NOVEL LIVER-TARGETING AGENTS AND THEIR SYNTHESIS
  申请人：LEE REIKO TAKASAKA

  公开号：US20110077386A1

  公开（公告）日：2011-03-31

  This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilo triacetic acid structure as backbone which acquires multivalency with saccharide groups, to bind with a galactosamine chain or lactose chain is disclosed. In particular, only one amino acid L-lysine is involved to provide trivalency. All carboxyl groups in N ε -benzyloxycarbonyl-N α -dicarboxymethyl-L-lysine can be conjugated with three glycosides of ahGalNAc or ahLac in one step. This invention also provides a hexa-lactoside. In particular, the TFA-AHA-Asp was used to conjugate 2 moles of NTA(ahLac) 3 . This invention also provides a method for adding a spacer between NTA and DTPA. The extended hepatocyte-specific glyco-ligand has higher 111 In-radiolabelling yield than those non-extended.

  该发明提供了新型的肝靶向药物及其合成方法。一种肝靶向药物，以赖氨酸为骨架，具有氨基三乙酸结构，通过与糖苷基团形成多价性，与半乳糖胺链或乳糖链结合。具体来说，仅涉及一种氨基酸L-赖氨酸，以提供三价性。Nε-苄氧羰基-Nα-二羧甲基-L-赖氨酸中的所有羧基可以在一步中与三个ahGalNAc或ahLac的糖苷结合。该发明还提供了一种六乳糖苷。具体来说，TFA-AHA-Asp被用于将2摩尔的NTA(ahLac)3结合。该发明还提供了一种在NTA和DTPA之间添加间隔物的方法。扩展的肝细胞特异性糖基配体的111In标记产率高于非扩展的配体。
• TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY
  申请人：Jung Francoise

  公开号：US20120283168A1

  公开（公告）日：2012-11-08

  Novel template-fixed β-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are α-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property to antagonize the receptor CCR10. They can be used as medicaments to treat or prevent diseases or conditions in the area of dermatological and cutaneous disorders, inflammation, allergic disorders, respiratory diseases, diseases of the gastro-intestinal tract, ophthalmic diseases, haematology and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

  具有以下一般式(I)的小说模板固定β-发夹仿生肽，其中单个元素T或P是α-氨基酸残基，可以连接在任何方向上，具体取决于它们在链中的位置，如描述和索赔中所定义，及其盐，具有拮抗受体CCR10的特性。它们可用作药物，用于治疗或预防皮肤病和皮肤疾病、炎症、过敏性疾病、呼吸道疾病、胃肠道疾病、眼科疾病、血液学和癌症等领域。这些β-发夹仿生肽可以通过基于混合固相和溶液相合成策略的过程制备。
• Anti-cancer compounds
  申请人：BRITISH TECHNOLOGY GROUP LIMITED

  公开号：EP0509643A1

  公开（公告）日：1992-10-21

  Quinazolines of the formula:- wherein R¹ is hydrogen or amino, or R¹ is alkyl, alkoxy or alkylthio each of up to 6 carbon atoms; or R¹ is aryl or aryloxy each of up to 10 carbon atoms; or R¹ is halogeno, hydroxy or mercapto; or R¹ is alkyl of up to 3 carbon atoms which bears one or more substituents selected from halogeno, hydroxy and alkanoylamino each of up to 6 carbon atoms; or R¹ is alkoxy of up to 3 carbon atoms which bears one or more substituents selected from hydroxy and alkoxy of up to 6 carbon atoms; wherein R² is hydrogen or alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, mercaptoalkyl, alkylthioalkyl, halogenoalkyl, cyanoalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyanoylalkyl, carboxyalkyl, carbamoylalkyl or alkanoyl each of up to 6 carbon atoms; wherein Ar is phenylene or heterocyclene which is unsubstituted or which bears one or more substituents selected from halogeno, cyano, nitro, hydroxy, amino and carbomoyl and alkyl, alkoxy, halogenoalkyl, alkanoylamino, alkylthio and alkoxycarbonyl each of up to 6 carbon atoms; R³ is the residue of a dipeptide in which the first, N-terminal amino acid residue thereof attached to the carbonyl group of COR³ COR³ is an L- or D-amino acid residue -NHCH(C₂H)-A-CO- in which A is an alkylene group of up to 6 carbon atoms and the second amino acid residue is of an α-amino acid which has the D-configuration at its asymmetric α-carbon atom; wherein R⁴ is hydrogen or alkyl of up to 4 carbon atoms; wherein R⁵ is hydrogen or alkyl of up to 4 carbon atoms; and wherein each of R⁶, R⁷ and R⁸ is hydrogen or alkyl or alkoxy each of up to 4 carbon atoms; or is halogeno; or a pharmaceutically-acceptable salt, ester or amide thereof are of therapeutic value, particularly in the treatment of cancer.

  式中的喹唑啉类 其中 R¹ 是氢或氨基、 或 R¹ 是烷基、烷氧基或硫代烷基，每个最多 6 个碳原子； 或 R¹ 是芳基或芳氧基，每个最多 10 个碳原子； 或 R¹ 是卤素、羟基或巯基； 或 R¹是碳原子数不超过 3 个的烷基，带有一个或多个取代基，这些取代基可从卤素、羟基和烷酰氨基中选择，每个取代基的碳原子数不超过 6 个； 或 R¹ 是碳原子数不超过 3 个的烷氧基，带有一个或多个从羟基和碳原子数不超过 6 个的烷氧基中选出的取代基； 其中 R² 是氢或烷基、烯基、炔基、羟基烷基、烷氧基烷基、巯基烷基、烷硫基烷基、卤代烷基、氰基烷基、氨基烷基、烷基氨基烷基、二烷基氨基烷基、烷酰基烷基、羧基烷基、氨基甲酰基烷基或烷酰基，每个烷基最多 6 个碳原子； 其中 Ar 是未被取代的苯基或杂环基，或带有一个或多个取代基，这些取代基可选 自卤素、氰基、硝基、羟基、氨基和碳酰基以及烷基、烷氧基、卤代烷基、烷酰氨基、烷硫基 和烷氧羰基，每个取代基的碳原子数最多为 6 个； R³ 是二肽残基，其中与 COR³ COR³ 的羰基相连的第一个 N 端氨基酸残基是 L 或 D 氨基酸残基-NHCH(C₂H)-A-CO-，其中 A 是最多 6 个碳原子的亚烷基，第二个氨基酸残基是在α-碳原子上具有 D 构型的α-氨基酸； 其中 R⁴ 是氢或最多 4 个碳原子的烷基； 其中 R⁵ 是氢或最多 4 个碳原子的烷基；以及 其中R⁶、R⁷和R⁸各自为氢或烷基或烷氧基，每个最多4个碳原子；或卤素； 或其药学上可接受的盐、酯或酰胺具有治疗价值，特别是在治疗癌症方面。
• Recording sheets containing amino acids, hydroxy acids, and polycarboxyl compounds
  申请人：XEROX CORPORATION

  公开号：EP0667246A1

  公开（公告）日：1995-08-16

  A recording sheet which comprises a paper substrate and a material selected from the group consisting of monomeric amino acids, monomeric hydroxy acids, monomeric polycarboxyl compounds, and mixtures thereof. Another embodiment of the present invention is directed to a recording sheet which comprises a substrate and a material selected from the group consisting of monomeric amino acids, monomeric hydroxy acids, and mixtures thereof.

  一种记录纸，它包括纸基材和选自单体氨基酸、单体羟基酸、单体聚羧基化合物及其混合物组成的组的材料。本发明的另一个实施方案涉及一种记录纸，它包括基材和选自单体氨基酸、单体羟基酸及其混合物组成的组的材料。
• Wash composition
  申请人：Ajinomoto Co., Inc.

  公开号：EP0826766A2

  公开（公告）日：1998-03-04

  A wash composition comprises an N-long-chain-acyl dipeptide or salt in which the dipeptide moiety is composed of acidic amino acids, and an N-long-chain-acyl acidic amino acid or salt. Embodiments of the composition may exhibit low irritation and an excellent resistance to hard water, be free from the turbidity and odour found in natural peptides, and have an excellent feeling upon use without any creaking feeling of the hair or stretching feeling of the skin.

  一种洗发水组合物包含一种 N-长链酰基二肽或盐，其中的二肽分子由酸性氨基酸和一种 N-长链酰基酸性氨基酸或盐组成。该组合物的实施方案可以表现出低刺激性和出色的耐硬水性，不含天然肽中的浑浊物和气味，并且在使用时具有出色的感觉，头发不会有吱吱作响的感觉，皮肤也不会有拉伸感。