2-(4-nitrophenyl)-4-phenyloxazole | 25205-88-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-nitrophenyl)-4-phenyloxazole
• 英文别名: 2-(4-Nitrophenyl)-4-phenyl-1,3-oxazole
• CAS: 25205-88-3
• 化学式: C₁₅H₁₀N₂O₃
• 分子量: 266.256
• InChiKey: BHKHYWVKWFDCLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-硝基苯甲酸苯甲酰甲基酯 在 乙酰胺 、 三氟化硼乙醚 作用下， 以30%的产率得到2-(4-nitrophenyl)-4-phenyloxazole
  参考文献：
  名称：

  Convenient Syntheses of 2-Alkyl(Aryl)-4,5-diphenyloxazoles and 2-Alkyl(Aryl)-4-phenyloxazoles

  摘要：

  DOI：

  10.1055/s-1998-6093

文献信息

• A versatile synthesis of 2,4-substituted oxazoles
  作者：Vijay Chudasama、Jonathan D. Wilden

  DOI：10.1039/b805430d

  日期：——

  A variety of five-membered ring oxazoles have been synthesised with complete regiocontrol and without the requirement for ring oxidation via a reaction sequence based on a vinyl sulfonamide template.

  已经合成了多种五元环恶唑，它们具有完全的区域控制性，并且不需要经由基于乙烯基磺酰胺模板的反应序列进行环氧化。
• A novel synthetic method of 2,4-disubstituted oxazoles using carboxylic acid-derived Bu2Sn[OC(O)R]2
  作者：Hiroki Yoneyama、Naoki Oka、Yoshihide Usami、Shinya Harusawa

  DOI：10.1016/j.tetlet.2020.151983

  日期：2020.6

  A novel synthetic method for the preparation of 2,4-disubstituted oxazoles was developed, entailing the reaction of dibutyltin diacylates Bu2Sn[OC(O)R](2) with 1-substituted acetylenes and TMSN3 to afford a range of 2,4-disubstituted oxazoles in good yields. (C) 2020 Elsevier Ltd. All rights reserved.
• Synthesis of 2,4- and 2,4,5-substituted oxazoles via a silver triflate mediated cyclization
  作者：Jessica L. Bailey、Ravinder R. Sudini

  DOI：10.1016/j.tetlet.2014.05.002

  日期：2014.7
• [EN] SYNTHETIC METHOD FOR DIRECT ARYLATION OF HETEROCYCLIC ARENES<br/>[FR] PROCEDE SYNTHETIQUE D'ARYLATION DIRECTE D'ARENES HETEROCYCLIQUES
  申请人：UNIV COLUMBIA

  公开号：WO2004069394A2

  公开（公告）日：2004-08-19

  Methods for the direct, selective arylation of carbon-hydrogen sites on various heteroaromatic compounds are disclosed. A method of the present invention includes contacting the heteroaromatic compound with a basic compound to form a first mixture, adding a second mixture comprising a catalyst to the first mixture to form a third mixture, and adding an Ar-X compound to the third mixture, wherein Ar comprises an aryl species and X comprises a leaving group.