3'-chloro-5,6-dihydro-2H-[1,2']-bipyridinyl-4-carboxylic acid (4-tert-butylphenyl)amide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3'-chloro-5,6-dihydro-2H-[1,2']-bipyridinyl-4-carboxylic acid (4-tert-butylphenyl)amide
• 英文别名: N-(4-tert-butylphenyl)-3'-chloro-3,6-dihydro-2H-[1,2']bipyridine-4-carboxamide；N-(4-tert-butylphenyl)-3'-chloro-3,6-dihydro-2H-1,2'-bipyridine-4-carboxamide；N-(4-tert-Butylphenyl)-1-(3-chloropyridin-2-yl)-1,2,3,6-tetrahydropyridine-4-carboxamide；N-(4-tert-butylphenyl)-1-(3-chloropyridin-2-yl)-3,6-dihydro-2H-pyridine-4-carboxamide
• 化学式: C₂₁H₂₄ClN₃O
• 分子量: 369.894
• InChiKey: YNLRTUISAONTAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(5-chloro-2-pyridyl)triflimide 在 palladium diacetate 1,3-双(二苯基膦)丙烷 、 三乙胺 、 lithium hexamethyldisilazane 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， -78.0~70.0 ℃ 、101.33 kPa 条件下， 反应 6.5h， 生成 3'-chloro-5,6-dihydro-2H-[1,2']-bipyridinyl-4-carboxylic acid (4-tert-butylphenyl)amide
  参考文献：
  名称：

  WO2005/4866

  摘要：

  公开号：

文献信息

• Novel amides useful for treating pain
  申请人：Zheng Zhu Guo

  公开号：US20050009841A1

  公开（公告）日：2005-01-13

  The present invention relates to compounds of formula (I) that useful in treating pain.

  本发明涉及一种用于治疗疼痛的化合物，其化学式为（I）。
• Amides useful for treating pain
  申请人：Abbott Laboratories

  公开号：US07129235B2

  公开（公告）日：2006-10-31

  The present invention relates to compounds of formula (I-VII) or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7 and R8 are defined herein. The present invention also relates to methods of trating pain using these compounds and pharmaceutical compositions including these compounds.

  本发明涉及式(I-VII)化合物或其药学上可接受的盐或前药，其中A、L、R6、R7和R8在此定义。本发明还涉及使用这些化合物治疗疼痛的方法和包括这些化合物的制药组合物。
• AMIDE DERIVATIVE
  申请人：Nakagawa Tadakiyo

  公开号：US20090258900A1

  公开（公告）日：2009-10-15

  Amide derivatives represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa—, —(CRbRb′)m-, and the like; m is 0 to 4; and R1 to R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, a carboxyl group, a formyl group, a hydroxyl group, an ammonium group, an alkyl group optionally having one or more substituents, -ZR18 and the like, Z is —O—, —S(O)p-, —S(O)pO—, —NH—, —NR19-, and the like; or a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof may be applied to pharmaceutical use such as anti-inflammatory and analgesic action and the like.

  式（I）所表示的酰胺衍生物，其中：A是环烷基团、芳基团或杂环芳基团；X是氮原子或CR17；Y是—NRa—、—(CRbRb′)m-等；m为0至4；R1至R17可能相同或不同，每个都是氢原子、卤素原子、氰基、硝基、羧基、甲酰基、羟基、铵基、可选具有一个或多个取代基的烷基、-ZR18等，Z是—O—、—S(O)p-、—S(O)pO—、—NH—、—NR19-等；或其药学上可接受的盐、水合物或溶剂化物可用于药物的使用，例如抗炎和镇痛作用等。
• Therapeutic agents useful for treating pain
  申请人：Kyle J. Donald

  公开号：US20070027159A1

  公开（公告）日：2007-02-01

  A compound of formula: wherein Ar 1 , Ar 2 , V, X, R 3 , R 4 , and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Cyclo(hetero)alkenyl Compound”); compositions comprising an effective amount of a Cyclo(hetero)alkenyl Compound; and methods for treating or preventing, e.g., pain, UI, an ulcer, IBD, or IBS in an animal, comprising administering to an animal in need thereof an effective amount of a Cyclo(hetero)alkenyl Compound are disclosed herein.

  本文披露了一种化合物，其分子式为：其中Ar1、Ar2、V、X、R3、R4和m如本文所述或其药学上可接受的盐（“环（杂）烯基化合物”）；包含有效量的环（杂）烯基化合物的组合物；以及治疗或预防动物的疼痛、尿失禁、溃疡、炎症性肠病或肠易激综合征等疾病的方法，包括向需要的动物中投与有效量的环（杂）烯基化合物。
• AMIDE DERIVATIVES AS TRPV1 ANTAGONISTS
  申请人：Vasudevan Anil

  公开号：US20090062345A1

  公开（公告）日：2009-03-05

  The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , and R 3 , are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

  本发明涉及式(I)化合物，或其药学上可接受的盐、前药、前药盐或其组合物，其中R1、R2和R3在说明书中有定义。还公开了包含这些化合物的组合物以及使用这些化合物和组合物治疗疾病和疾患的方法。