苄基三苯基鏻碘化物 | 1243-97-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苄基三苯基鏻碘化物
• 中文别名: 苄基三苯基碘化膦
• 英文名称: benzyltriphenylphosphonium iodide
• 英文别名: Benzyltriphenylphosphonium-iodid；Triphenyl-benzyl-phosphonium-iodid；benzyl(triphenyl)phosphanium;iodide
• CAS: 1243-97-6
• 化学式: C₂₅H₂₂P*I
• 分子量: 480.328
• InChiKey: JOZHCQBYRBGYAJ-UHFFFAOYSA-M

物化性质

• 熔点：
  261-263 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2.18
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  苄基三苯基鏻碘化物 在 甲基锂 作用下， 以 氯仿 为溶剂， 反应 112.0h， 生成 (1E,3Z)-1,4-diphenyl-3-furan-2-yl-2-azabuta-1,3-diene
  参考文献：
  名称：

  Aza-Wittig Reaction of N-Vinylic Phosphazenes with Carbonyl Compounds. Azadiene-Mediated Synthesis of Isoquinolines and 5,6-Dihydro-2H-1,3-oxazines

  摘要：

  N-Vinylic phosphazenes 4 are obtained by reaction of phosphorus ylide 5 and nitriles 6. Aza-Wittig reaction of phosphazenes 4 with aldehydes leads to the formation of 2-azadienes 1, which are easily converted into isoquinolines 2. Reaction of conjugated phosphazenes 4 with ethyl glyoxalate affords 5,6-dihydro-2H-1,3-oxazines 9 in a regio- and stereoselective fashion, while heterodienes 1 react with ethyl glyoxalate and diethyl ketomalonate giving 1,3-oxazines 11 and 12.

  DOI：

  10.1021/jo961664n
• 作为产物：
  描述：

  氯化苄 在 sodium iodide 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 18.0h， 生成 苄基三苯基鏻碘化物
  参考文献：
  名称：

  JP6172152

  摘要：

  公开号：

文献信息

• Preparation of 3-(Fluoroalkyl)-2-azadienes and Its Application in the Synthesis of (Fluoroalkyl)isoquinoline and -pyridine Derivatives
  作者：Francisco Palacios、Concepción Alonso、Marta Rodríguez、Eduardo Martínez de Marigorta、Gloria Rubiales

  DOI：10.1002/ejoc.200400770

  日期：2005.5

  A method for the preparation of 3-(fluoroalkyl)-substituted 2-azabutadienes 5 by aza-Wittig reaction of N-vinylic 3-(fluoroalkyl)phosphazenes 4 and aldehydes is reported. Thermal 6π-electrocyclization of these azadienes gives 3-(fluoroalkyl)-substituted isoquinolines 6. Also [4+2] cycloaddition of these heterodienes 5 with enamine 8 gives fluoroalkyl-substituted pyridine derivatives 10–16. However,

  报道了一种通过 N-乙烯基 3-(氟烷基) 磷腈 4 和醛的氮杂-维蒂希反应制备 3-(氟烷基)-取代的 2-氮杂丁二烯 5 的方法。这些氮杂二烯的热 6π-电环化得到 3-(氟烷基)-取代的异喹啉 6。这些杂二烯 5 与烯胺 8 的 [4+2] 环加成得到氟烷基取代的吡啶衍生物 10-16。然而，氮杂二烯 17 与偶氮化合物 18 的反应得到双环杂环 19。 (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
• Aza-Wittig reaction of fluoroalkylated N-vinylic phosphazenes with carbonyl compounds. Usefulness of 2-azadienes for the preparation of fluoroalkyl pyridine derivatives
  作者：Francisco Palacios、Concepción Alonso、Gloria Rubiales、Maite Villegas

  DOI：10.1016/j.tet.2005.01.080

  日期：2005.3

  A method for the preparation of 3-fluoroalkyl substituted 2-aza-butadienes 6 by aza-Wittig reaction of 3-fluoroalkyl-N-vinylic phosphazenes 4 and aldehydes 5 is reported. [4+2] Cycloaddition reaction of these heterodienes 6 with enamines 9 gives fluoroalkyl substituted pyridine 15, 16, 24–27 and isoquinoline 12–14, 20 derivatives.

  报道了通过3-氟烷基-N-乙烯基磷腈4和醛5的氮杂-Wittig反应制备3-氟烷基取代的2-氮杂-丁二烯6的方法。这些heterodienes [4 + 2]环加成反应6与烯胺9给出氟烷取代的吡啶15，16，24 - 27和异喹啉12 - 14，20个衍生物。
• CN-assisted oxidative cyclization of cyano cinnamates and styrene derivatives: a facile entry to 3-substituted chiral phthalides
  作者：R. Santhosh Reddy、I. N. Chaithanya Kiran、Arumugam Sudalai

  DOI：10.1039/c2ob25409c

  日期：——

  of o-cyano cinnamates and styrene derivatives leads to efficient construction of chiral phthalide frameworks in high optical purities. This unique reaction is characterized by unusual synergism between CN and osmate groups resulting in rate enhancement of the AD process. The method is amply demonstrated by the synthesis and the structural/stereochemical assignment of the natural products.

  邻氰基肉桂酸酯和苯乙烯衍生物的不对称二羟基化（AD）导致高光学纯度的手性邻苯二甲酸酯骨架的有效构建。这种独特的反应的特征在于CN和渗透酸基团之间异常的协同作用，从而导致AD过程的速率提高。天然产物的合成和结构/立体化学分配充分证明了该方法。
• [EN] IMPROVED PROCESS FOR THE MANUFACTURE OF 1,2-DISUBSTITUTED HEXAHYDROPYRIDAZINE-3-CARBOXYLIC ACIDS AND ESTERS THEREOF<br/>[FR] PROCEDE AMELIORE DE FABRICATION D'ACIDES HEXAHYDROPYRIDAZINE-3-CARBOXYLIQUES 1,2-DISUBSTITUES ET LEURS ESTERS
  申请人：HONEYWELL SPECIALTY CHEMICALS

  公开号：WO2005028449A1

  公开（公告）日：2005-03-31

  The invention relates to an improved process for the manufacture of 1,2-disubstituted hexahydro-pyridazine-3-carboxylic acids and esters thereof by reacting N,N’-disubstituted hydrazine with 2,5-dihalogenated valeric acids and thereof by means of phase transfer catalysis. Said pyridazine carboxylic acids and esters thereof can be used as intermediates for the production of pharmaceutical products

  该发明涉及一种改进的工艺，通过相转移催化作用，将N,N'-二取代肼与2,5-二卤代戊二酸反应，制备1,2-二取代六氢吡啶并-3-羧酸及其酯。所述吡啶羧酸及其酯可用作制药产品的中间体。
• Process for the preparation cyano carboxylic acid esters
  申请人：Lonza Ltd

  公开号：EP2455365A1

  公开（公告）日：2012-05-23

  The present invention relates to a process for the preparation of a cyano carboxylic acid ester of the formula wherein R1 is a linear or branched C1-8 alkanediyl group; and R2 is a linear or branched alkyl group, a cycloalkyl group, or an aryl or arylalkyl group, wherein aryl is optionally substituted with one or more C1-8 alkyl groups; comprising reacting a halo carboxylic acid ester of the formula wherein R1 and R2 are as defined above; and Hal is fluorine, chlorine, bromine or iodine; in a reaction mixture comprising a homogeneous liquid phase, wherein the liquid phase consists of water and an organic solvent, with an alkali metal cyanide in the presence of hydrogen cyanide, optionally in the presence of a catalyst, to obtain the cyano carboxylic acid ester of the formula (I).

  本发明涉及一种制备氰基羧酸酯的过程，其化学式为其中R1是直链或支链的C1-8烷二基基团；R2是直链或支链的烷基团、环烷基团或芳基或芳基烷基团，其中芳基可以选择性地与一个或多个C1-8烷基团取代；包括在反应混合物中反应化学式为的卤代羧酸酯其中R1和R2如上定义；Hal是氟、氯、溴或碘；在包含均相液相的反应混合物中，液相由水和有机溶剂组成，与碱金属氰化物在氢氰的存在下反应，可选地在催化剂的存在下，以获得化学式（I）的氰基羧酸酯。