4-methyl-2-((4-methylanilino)methyl)phenol | 97359-35-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-2-((4-methylanilino)methyl)phenol
• 英文别名: 4-methyl-2-[(p-tolylamino)methyl]phenol；4-Methyl-2-p-toluidinomethyl-phenol；(6-Oxy-3-methyl-benzyl)-p-toluidin；4-Methyl-2-[(4-methylanilino)methyl]phenol
• CAS: 97359-35-8
• 化学式: C₁₅H₁₇NO
• 分子量: 227.306
• InChiKey: GFZRBABPYBXNBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  三光气 、 4-methyl-2-((4-methylanilino)methyl)phenol 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 以93%的产率得到6-methyl-3-(4-methylphenyl)-3,4-dihydro-2H-1,3-benzoxazin-2-one
  参考文献：
  名称：

  具有杀菌活性的3,4(6)-二取代-1,3-苯并噁 嗪-2-酮类化合物

  摘要：

  本发明提供一类如式（I）所示的3,4(6)-二取代-1,3-苯并噁嗪-2-酮类化合物，式（I）中，取代基R1是-CH3、R2是H时，R3是H，或者是3-CH3，或者是4-CH3，或者是2-OCH3，或者是4-Cl；取代基R1是H、R2是-CH3时，R3是3-CH3，或者是4-CH3，或者是2-OCH3，或者是3-OCH3，或者是4-Cl。该类化合物对农作物病菌具有很好的杀菌活性。？（I）。

  公开号：

  CN104045604B
• 作为产物：
  描述：

  5-methyl-salicylidene-p-methylaniline 在 sodium amalgam 作用下， 生成 4-methyl-2-((4-methylanilino)methyl)phenol
  参考文献：
  名称：

  Noda, Nippon Kagaku Zasshi, 1959, vol. 80, p. 321,324

  摘要：

  DOI：

文献信息

• Protein-Polymer-Drug Conjugates
  申请人：MERSANA THERAPEUTICS, INC.

  公开号：US20130101546A1

  公开（公告）日：2013-04-25

  A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L D -D, the protein based recognition-molecule being connected to the polymeric carrier by L P . Each occurrence of D is independently a therapeutic agent having a molecular weight≦5 kDa. L D and L P are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

  本文提供了一种药物结合物。该结合物包括一种基于蛋白质的识别分子（PBRM）和一种聚合物载体，该聚合物载体被替换为一个或多个-LD-D，基于蛋白质的识别分子通过LP连接到聚合物载体上。每个D的出现都是分子量≦5 kDa的治疗剂。LD和LP是连接治疗剂和PBRM到聚合物载体的链接剂。还公开了用于与PBRM结合形成聚合物-药物-PBRM结合物的聚合物支架，包括结合物的组成，其制备方法以及使用结合物或其组成物治疗各种疾病的方法。
• PROTEIN-POLYMER-DRUG CONJUGATES
  申请人：MERSANA THERAPEUTICS, INC.

  公开号：US20150044160A1

  公开（公告）日：2015-02-12

  A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L D -D, the protein based recognition-molecule being connected to the polymeric carrier by L P . Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. L D and L P are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

  本文提供一种药物偶联物。该偶联物包括一种基于蛋白质的识别分子（PBRM）和一种聚合物载体，其取代了一个或多个-LD-D，其中，基于蛋白质的识别分子通过LP连接到聚合物载体上。每个D的出现都是独立的，其分子量≦5 kDa，是一种治疗剂。LD和LP是连接治疗剂和PBRM到聚合物载体的连接体。还公开了用于与PBRM偶联形成聚合物-药物-PBRM偶联物的聚合物支架，包括所述偶联物的组合物，其制备方法以及使用偶联物或其组合物治疗各种疾病的方法。
• Terminally Modified Polymers and Conjugates Thereof
  申请人：Mersana Therapeutics, Inc.

  公开号：US20140017265A1

  公开（公告）日：2014-01-16

  A terminally modified polymer is provided herein. At least one terminus of the polymer is —O—(CH 2 ) 2 -L M or —O—CH 2 —CH(OH)—CH 2 —CR 1 ═CR 2 R 3 . L M , R 1 , R 2 , and R 3 are defined herein Also disclosed are terminal conjugates comprising the polymer and a pharmaceutically useful modifier, as well as compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

  本文提供了一种终止修饰的聚合物。聚合物的至少一个端点是—O—（CH2）2-LM或—O—CH2—CH（OH）—CH2—CR1═CR2R3。其中LM，R1，R2和R3在本文中有定义。此外，本文还披露了包括该聚合物和药物有用修饰剂的终端共轭物，以及包括共轭物的组合物、其制备方法以及使用共轭物或其组合物治疗各种疾病的方法。
• AURISTATIN COMPOUNDS AND CONJUGATES THEREOF
  申请人：MERSANA THERAPEUTICS, INC.

  公开号：US20150314008A1

  公开（公告）日：2015-11-05

  An auristatin compound conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L D -D, the protein based recognition-molecule being connected to the polymeric carrier by L p . Each occurrence of D is independently an auristatin compound having a molecular weight ≦5 kDa. L D and L p are distinct linkers connecting the auristatin compound and PBRM to the polymeric earner respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-auristatin compound-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

  本文提供了一种auristatin化合物结合物。该结合物包括以蛋白质为基础的识别分子（PBRM）和多聚载体，该多聚载体被取代了一个或多个-LD-D，蛋白质基础的识别分子通过Lp连接到多聚载体上。每个D的出现都是独立的，具有分子量≦5 kDa的auristatin化合物。 LD和Lp是连接auristatin化合物和PBRM到多聚载体的不同连接物。还公开了用于与PBRM共轭形成在此处描述的聚合物-auristatin化合物-PBRM结合物的聚合物支架，包括结合物的组成，其制备方法以及使用结合物或其组成治疗各种疾病的方法。
• TUBULYSIN COMPOUNDS AND CONJUGATES THEREOF
  申请人：Mersana Therapeutics, Inc.

  公开号：US20160022829A1

  公开（公告）日：2016-01-28

  A tubulysin compound conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L D -D, the protein based recognition-molecule being connected to the polymeric carrier by L P . Each occurrence of D is independently a tubulysin compound having a molecular weight≦5 kDa. L D and L P are distinct linkers connecting the tubulysin compound and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-tubulysin compound-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

  本文提供了一种管芽菌素化合物结合物。该结合物包括一种基于蛋白质的识别分子（PBRM）和一种聚合物载体，该聚合物载体被取代了一个或多个-LD-D，其中，基于蛋白质的识别分子通过LP连接到聚合物载体上。每个D的出现独立地是分子量≦5 kDa的管芽菌素化合物。LD和LP是连接管芽菌素化合物和PBRM分别到聚合物载体的不同连接物。还公开了用于与PBRM结合形成聚合物-管芽菌素化合物-PBRM结合物的聚合物支架，包括结合物的组合物，其制备方法以及使用结合物或其组合物治疗各种疾病的方法。