5-bromo-2-(1H-imidazol-2-yl)pyridine | 1211586-40-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-bromo-2-(1H-imidazol-2-yl)pyridine
• CAS: 1211586-40-1
• 化学式: C₈H₆BrN₃
• 分子量: 224.06
• InChiKey: OZKHSJCPLPWZKI-UHFFFAOYSA-N

物化性质

• 沸点：
  403.6±30.0 °C(Predicted)
• 密度：
  1.651±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-bromo-2-(1H-imidazol-2-yl)pyridine 在 copper(l) iodide 、 cesium hydroxide 、 盐酸 作用下， 以 水 、 二甲基亚砜 、 叔丁醇 为溶剂， 反应 24.0h， 生成 6-(1H-imidazol-2-yl)pyridin-3-ol
  参考文献：
  名称：

  CuI-catalyzed hydroxylation of aryl bromides under the assistance of 5-bromo-2-(1H-imidazol-2-yl)pyridine and related ligands

  摘要：

  A number of substituted 2-pyridin-2-yl-1H-benzoimidazoles and 2-(1H-imidazol-2-yl)pyridines were screened for promoting CuI-catalyzed hydroxylation of aryl bromides, which led to the discovery of the combination of Cut and 5-bromo-2-(1H-imidazol-2-yl)pyridine as an effective catalytic system for this transformation. Both electron-rich and electronic-deficient aryl bromides could be converted into the corresponding substituted phenols in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.059
• 作为产物：
  描述：

  5-bromopyridine-2-methylimidate 在 盐酸 、 sodium carbonate 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 生成 5-bromo-2-(1H-imidazol-2-yl)pyridine
  参考文献：
  名称：

  含有哌嗪基的化合物

  摘要：

  本申请属于药物化学领域，涉及含有哌嗪基的化合物，具体涉及式(II)所示化合物、其立体异构体或其药学上可接受的盐、其制备方法、含有该化合物的药物组合物以及其在治疗相关疾病(例如癌症)中的用途。

  公开号：

  CN116496271A
• 作为试剂：
  描述：

  4-溴代联苯 在 copper(l) iodide 、 cesium hydroxide 、 5-bromo-2-(1H-imidazol-2-yl)pyridine 、 盐酸 作用下， 以 水 、 二甲基亚砜 、 叔丁醇 为溶剂， 反应 36.0h， 以86%的产率得到对羟基联苯
  参考文献：
  名称：

  CuI-catalyzed hydroxylation of aryl bromides under the assistance of 5-bromo-2-(1H-imidazol-2-yl)pyridine and related ligands

  摘要：

  A number of substituted 2-pyridin-2-yl-1H-benzoimidazoles and 2-(1H-imidazol-2-yl)pyridines were screened for promoting CuI-catalyzed hydroxylation of aryl bromides, which led to the discovery of the combination of Cut and 5-bromo-2-(1H-imidazol-2-yl)pyridine as an effective catalytic system for this transformation. Both electron-rich and electronic-deficient aryl bromides could be converted into the corresponding substituted phenols in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.059

文献信息

• [EN] OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS<br/>[FR] DERIVES D'OXAZOLIDINONE UTILISES COMME AGENTS ANTIMICROBIENS
  申请人：RANBAXY LAB LTD

  公开号：WO2006038100A1

  公开（公告）日：2006-04-13

  The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, for example, Bacterioides spp. and Clostridia spp. species, and acid fast organisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

  本发明涉及某些取代苯基噁唑烷酮以及其合成方法。本发明还涉及含有本发明化合物作为抗微生物药物的药物组合物。这些化合物是有用的抗微生物剂，对多种人类和兽医病原体有效，包括革兰氏阳性厌氧细菌，例如多重耐药葡萄球菌、链球菌和肠球菌，以及厌氧生物，例如Bacterioides属和Clostridia属物种，以及耐酸生物，例如结核分枝杆菌、埃维分枝杆菌和分枝杆菌属。
• Novel oxazolidinone derivatives and a process for the preparation thereof
  申请人：——

  公开号：US20030166620A1

  公开（公告）日：2003-09-04

  The present invention relates to novel oxazolidinone derivatives, their pharmaceutically acceptable salts and a process for the preparation thereof. More particularly, the present invention relates to oxazolidinone derivatives having pyridine or pyrimidine moeity substituted by heterocycle and heteroaromaticcycle at 4-position of phenyl ring. The compounds of the present invention have wide antibacterial spectrum, superior antibacterial activity and low toxicity, such that the compound of this invention can be used as an antibacterial agent.

  本发明涉及新颖的噁唑烷酮衍生物，其药用盐以及其制备方法。更具体地，本发明涉及在苯环的4位被杂环和杂芳环取代的噁唑烷酮衍生物。本发明的化合物具有广泛的抗菌谱、优越的抗菌活性和低毒性，因此本发明的化合物可用作抗菌剂。
• [EN] QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS<br/>[FR] DÉRIVÉS DE QUINAZOLINONE EN TANT QU'AGENTS ANTIVIRAUX
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2012087938A1

  公开（公告）日：2012-06-28

  Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).

  提供了化合物及其药用盐，它们的药物组合物，它们的制备方法，以及它们用于治疗由黄病毒科（Flaviviridae）家族成员介导的病毒感染，如丙型肝炎病毒（HCV）的用途。
• [EN] NOVEL OXAZOLIDINONE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF<br/>[FR] NOUVEAUX DERIVES OXAZOLIDINONE ET PROCESSUS DE PREPARATION DE CES DERIVES
  申请人：DONG A PHARM CO LTD

  公开号：WO2001094342A1

  公开（公告）日：2001-12-13

  The present invention relates to novel oxazolidinone derivatives, their pharmaceutically acceptable salts and a process for the preparation thereof. More particularly, the present invention relates to oxazolidinone derivatives having pyridine or pyrimidine moeity substituted by heterocycle and heteroaromaticcycle at 4-position of phenyl ring. The compounds of the present invention have wide antibacterial spectrum, superior antibacterial activity and low toxicity, such that the compound of this invention can be used as an antibacterial agent.

  本发明涉及新型噁唑烷衍生物，其药学上可接受的盐以及其制备方法。更具体地说，本发明涉及在苯环的4位上以杂环和杂芳环取代的吡啶或嘧啶基团的噁唑烷衍生物。本发明的化合物具有广泛的抗菌谱、优越的抗菌活性和低毒性，因此本发明的化合物可用作抗菌剂。
• Heteroaryl alkyne compound and use thereof
  申请人：NANJING SANHOME PHARMACEUTICAL CO., LTD.

  公开号：US09255107B2

  公开（公告）日：2016-02-09

  In the field of pharmaceutical chemistry compounds of general formula I having heteroaryl alkynyl moiety or pharmaceutically acceptable salts, isomers, solvates, crystals or prodrugs thereof, and pharmaceutical compositions including these compounds, as well as uses of these compounds and compositions thereof in the manufacture of a medicament. The compounds have a strong inhibitory effect on BCR-ABL tyrosine kinase and are useful for treating diseases, such as tumors.

  在药物化学领域，具有杂环炔基取代基的一般式I化合物或其药学上可接受的盐、异构体、溶剂合物、晶体或前药，以及包括这些化合物的药物组合物，在制造药物方面的用途。这些化合物具有强烈的抑制BCR-ABL酪氨酸激酶的作用，并可用于治疗肿瘤等疾病。