6-chloro-2-trifluoromethylimidazo[1,2-b]pyridazin-3-ylsulfonamide | 570416-53-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-chloro-2-trifluoromethylimidazo[1,2-b]pyridazin-3-ylsulfonamide
• 英文别名: 6-Chloro-2-(trifluoromethyl)imidazo[1,2-b]pyridazine-3-sulfonamide
• CAS: 570416-53-4
• 化学式: C₇H₄ClF₃N₄O₂S
• 分子量: 300.649
• InChiKey: ZDYXEPODTNZIMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  98.7
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6-chloro-2-trifluoromethylimidazo[1,2-b]pyridazin-3-ylsulfonamide 、 乙硫醇 在 potassium tert-butylate 、 盐酸 、 水 作用下， 以 叔丁醇 为溶剂， 反应 4.0h， 以50%的产率得到6-ethylthio-2-trifluoromethylimidazo[1,2-b]pyridazin-3-ylsulfonamide
  参考文献：
  名称：

  FUSED HETEROCYCLIC SULFONYLUREA COMPOUND, HERBICIDE CONTAINING THE SAME, AND METHOD OF CONTROLLING WEED WITH THE SAME

  摘要：

  公开号：

  EP1466527B1
• 作为产物：
  描述：

  6-氯-2-(三氟甲基)咪唑并[1,2-b]吡嗪 在 氯磺酸 、 三乙胺 、 三氯氧磷 、 氨 、 水 作用下， 以 1,1,2,2-四氯乙烷 、 乙腈 为溶剂， 反应 13.0h， 以46.6%的产率得到6-chloro-2-trifluoromethylimidazo[1,2-b]pyridazin-3-ylsulfonamide
  参考文献：
  名称：

  FUSED HETEROCYCLIC SULFONYLUREA COMPOUND, HERBICIDE CONTAINING THE SAME, AND METHOD OF CONTROLLING WEED WITH THE SAME

  摘要：

  公开号：

  EP1466527B1

文献信息

• Novel process for producting imidazo[1,2-b]pyridazine derivative
  申请人：Tabuchi Takanori

  公开号：US20050171108A1

  公开（公告）日：2005-08-04

  A process for easily and inexpensively producing an imidazo[1,2-b]pyridazin-3-ylsulfonamide derivative which has a substituent bonded to the 6-position carbon atom and is represented by the formula (II): (wherein R represents lower alkyl, lower cycloalkyl optionally substituted by lower alkyl, lower alkenyl, or lower alkynyl), the process comprising reacting an imidazo[1,2-b]pyridazine compound represented by the formula (I): (wherein X represents halogeno or lower alkyl optionally substituted by halogeno; Y represents hydrogen or SO 2 N═CH—NR 1 R 2 ; and Z represents halogeno or OSO 2 R 3 ) with an organometallic compound in the presence of a transition metal catalyst. The derivative is useful as an intermediate for herbicides.

  一种用于简便、低成本地生产具有取代基与6-位碳原子键合的咪唑[1,2-b]吡嗪-3-基磺酰胺衍生物的方法，其化学式表示为(II):(其中R代表低烷基、低环烷基(可选地被低烷基取代)、低烯基或低炔基)，该方法包括在过渡金属催化剂的存在下，将咪唑[1,2-b]吡嗪化合物与有机金属化合物反应，所述咪唑[1,2-b]吡嗪化合物的化学式表示为(I):(其中X代表卤素或低烷基(可选地被卤素取代)；Y代表氢或SO2N═CH—NR1R2；Z代表卤素或OSO2R3)。该衍生物可用作除草剂的中间体。
• Fused heterocyclic sulfonylurea compound herbicide containing the same and method of controlling weed with the same
  申请人：Tanaka Yasushi

  公开号：US20050032650A1

  公开（公告）日：2005-02-10

  The present invention provides a compound represented by the formula: wherein Q represents a fused heterocyclic group, X and Y are the same or different and each represent an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group, etc., or a salt thereof, as well as a herbicide comprising the compound or a salt thereof, which exhibits a significant effect for control of sulfonylurea herbicide-resistant weeds in paddy fields and can reduce the number of active ingredients in a combined preparation and a method of controlling sulfonylurea herbicide-resistant weeds which comprises using the same.

  本发明提供了一种由以下式子表示的化合物：其中Q代表融合的杂环基团，X和Y相同或不同，每个代表可选的卤代低烷基，可选的卤代低烷氧基等，或其盐，以及包含该化合物或其盐的除草剂，在稻田中对磺酰脲除草剂耐药杂草具有显著的控制效果，可以减少联合制剂中的活性成分数量，并且包括使用该化合物的控制磺酰脲除草剂耐药杂草的方法。
• Process for producting imidazo[1,2-b]pyridazine derivative
  申请人：Sumitomo Chemical Takeda Agro Company, Limited

  公开号：US07307165B2

  公开（公告）日：2007-12-11

  A process for easily and inexpensively producing an imidazo[1,2-b]pyridazin-3-ylsulfonamide derivative which has a substituent bonded to the 6-position carbon atom and is represented by the formula (II): (wherein R represents lower alkyl, lower cycloalkyl optionally substituted by lower alkyl, lower alkenyl, or lower alkynyl), the process comprising reacting an imidazo[1,2-b]pyridazine compound represented by the formula (I): (wherein X represents halogeno or lower alkyl optionally substituted by halogeno; Y represents hydrogen or SO2N═CH—NR1R2; and Z represents halogeno or OSO2R3) with an organometallic compound in the presence of a transition metal catalyst. The derivative is useful as an intermediate for herbicides.

  一种用于轻松、廉价地生产在6位碳原子上与取代基成键并由公式（II）表示的咪唑并[1,2-b]吡嗪-3-基磺酰胺衍生物的方法，其中R代表较低的烷基、较低的环烷基（可选地被较低的烷基取代）、较低的烯基或较低的炔基，该方法包括在过渡金属催化剂的存在下将由公式（I）表示的咪唑并[1,2-b]吡嗪化合物与有机金属化合物反应。该衍生物可用作除草剂的中间体。
• Fused heterocyclic sulfonylurea compound, herbicide containing the same, and method for controlling weed with the same
  申请人：Tanaka Yasushi

  公开号：US20100160163A1

  公开（公告）日：2010-06-24

  The present invention provides a compound represented by the formula: wherein Q represents a fused heterocyclic group, X and Y are the same or different and each represent an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group, etc., or a salt thereof, as well as a herbicide comprising the compound or a salt thereof, which exhibits a significant effect for control of sulfonylurea herbicide-resistant weeds in paddy fields and can reduce the number of active ingredients in a combined preparation and a method of controlling sulfonylurea herbicide-resistant weeds which comprises using the same.

  本发明提供了一种化合物，其表示为公式：其中Q代表融合的杂环基团，X和Y相同或不同，每个代表可选的卤代较低烷基基团，可选的卤代较低烷氧基团等，或其盐，以及包含该化合物或其盐的除草剂，该除草剂对水稻田中的磺酰脲除草剂抗性杂草具有显着的控制效果，并且可以减少组合制剂中活性成分的数量，以及使用该化合物来控制磺酰脲除草剂抗性杂草的方法。
• Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same
  申请人：Sumitomo Chemical Company, Limited

  公开号：US07816526B2

  公开（公告）日：2010-10-19

  The present invention provides a compound represented by the formula: wherein Q represents a fused heterocyclic group, X and Y are the same or different and each represent an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group, etc., or a salt thereof, as well as a herbicide comprising the compound or a salt thereof, which exhibits a significant effect for control of sulfonylurea herbicide-resistant weeds in paddy fields and can reduce the number of active ingredients in a combined preparation and a method of controlling sulfonylurea herbicide-resistant weeds which comprises using the same.

  本发明提供一种化合物，其表示为以下公式： 其中，Q代表融合的杂环基团，X和Y相同或不同，每个代表可选的卤代较低烷基基团，可选的卤代较低烷氧基基团等，或其盐。此外，本发明还提供一种除草剂，包括该化合物或其盐，该除草剂在稻田中对磺酰脲类除草剂抗性杂草具有显著的控制效果，并且可以减少联合制剂中的活性成分数量，以及使用该除草剂控制磺酰脲类除草剂抗性杂草的方法。