4-<4-Nitro-phenyl>-butyliodid | 99067-72-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-<4-Nitro-phenyl>-butyliodid
• 英文别名: 4-Iod-1-<4-nitro-phenyl>-butan；1-(4-Iodobutyl)-4-nitrobenzene
• CAS: 99067-72-8
• 化学式: C₁₀H₁₂INO₂
• 分子量: 305.115
• InChiKey: XGUDGWHORQVYNI-UHFFFAOYSA-N

物化性质

• 沸点：
  369.2±25.0 °C(Predicted)
• 密度：
  1.640±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-<4-Nitro-phenyl>-butyliodid 在 sodium azide 、 dimethyl sulfide borane 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 42.42h， 生成 1-(6-Azido-5-azidomethyl-hexyl)-4-nitro-benzene
  参考文献：
  名称：

  DNA-directed alkylating agents. 2. Synthesis and biological activity of platinum complexes linked to 9-anilinoacridine

  摘要：

  Two different classes of cis-diaminedichloroplatinum(II) complexes linked to the DNA-intercalating chromophore 9-anilinoacridine have been synthesized and evaluated as DNA-targeted antitumor agents. Two different Pt chelating ligands were investigated (based on 1,2-ethanediamine and 1,3-propanediamine), designed to deliver the Pt in an orientation likely to respectively enhance either intrastrand or interstrand cross-linking. Although both sets of ligands were somewhat unstable under neutral or basic conditions with respect to disproportionation, the corresponding Pt complexes, once prepared, appeared to be quite stable. All the Pt complexes were monitored for purity by TLC, HPLC, and FAB mass spectra, and the mode of Pt coordination was established by 195Pt NMR spectroscopy. The complexes appeared to cause simultaneous platination and intercalative unwinding of plasmid DNA. In vitro studies were carried out with both wild-type and cisplatin-resistant P388 cell lines. Whereas cisplatin itself and the ethylenediamine and 1,3-propanediamine complexes used as standards were about 10-fold less active against the resistant line, the ethylenediamine-linked Pt complexes showed no differential toxicity between the two lines and the propanediamine-linked complexes showed significant differentials (up to 8-fold) in favor of the cisplatin-resistant line. However, these were no greater than those shown by the unplatinated ligands themselves. The majority of the acridine complexes were inactive in vivo against the wild-type P388 leukemia. They were very insoluble, and although a suitable formulation was found, this may have been a factor. It is also possible that these compounds bind in such a way as to direct the Pt away from the major groove.

  DOI：

  10.1021/jm00173a015
• 作为产物：
  描述：

  1-氯-4-苯基丁烷 在 硝酸 、 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 60.0h， 生成 4-<4-Nitro-phenyl>-butyliodid
  参考文献：
  名称：

  Iliceto,A. et al., Gazzetta Chimica Italiana, 1960, vol. 90, p. 660 - 670

  摘要：

  DOI：

文献信息

• NOVEL DIAMINE, POLYAMIC ACID, AND POLYIMIDE
  申请人：NISSAN CHEMICAL INDUSTRIES. LTD.

  公开号：US20160264520A1

  公开（公告）日：2016-09-15

  To provide a novel diamine, and a polyimide precursor and a polyimide using it. A diamine represented by the formula (1): wherein each of X 1 and X 5 which are independent of each other, is a single bond or the like; each of X 2 and X 4 which are independent of each other, is —CH 2 — or the like; X 3 is a C 1-6 alkylene or the like; each of Y 1 and Y 2 which are independent of each other, is a single bond or the like; R is a C 1-20 linear, branched or cyclic hydrocarbon group; and a is 0 or 1).

  提供一种新颖的二胺，以及使用它的聚酰亚胺前体和聚酰亚胺。一种由式（1）表示的二胺：其中X1和X5中的每一个独立的，是单键或类似物；X2和X4中的每一个独立的，是—CH2—或类似物；X3是C1-6烷基或类似物；Y1和Y2中的每一个独立的，是单键或类似物；R是C1-20线性、支链或环烃基；a为0或1。
• Diamine, polyamic acid, and polyimide
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US10023530B2

  公开（公告）日：2018-07-17

  To provide a novel diamine, and a polyimide precursor and a polyimide using it. A diamine represented by the formula (1): wherein each of X1 and X5 which are independent of each other, is a single bond or the like; each of X2 and X4 which are independent of each other, is —CH2— or the like; X3 is a C1-6 alkylene or the like; each of Y1 and Y2 which are independent of each other, is a single bond or the like; R is a C1-20 linear, branched or cyclic hydrocarbon group; and a is 0 or 1).

  提供一种新型二胺、一种聚酰亚胺前体和一种使用该二胺的聚酰亚胺。由式（1）表示的二胺： 其中相互独立的 X1 和 X5 各为单键或类似物；相互独立的 X2 和 X4 各为-CH2-或类似物；X3 为 C1-6 亚烷基或类似物；相互独立的 Y1 和 Y2 各为单键或类似物；R 为 C1-20 直链、支链或环状烃基；a 为 0 或 1）。
• CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP0904262B1

  公开（公告）日：2004-04-21