bis[2,2-(2-bromoisobutyryl)hydroxymethyl]propionic acid | 219994-55-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: bis[2,2-(2-bromoisobutyryl)hydroxymethyl]propionic acid
• 英文别名: 2,2-bis(((2'-bromo-2'-methylpropionyl)oxy)methyl)propionic acid；2,2-Bis(2-bromoisobutyryloxymethyl)propionic acid；3-(2-bromo-2-methylpropanoyl)oxy-2-[(2-bromo-2-methylpropanoyl)oxymethyl]-2-methylpropanoic acid
• CAS: 219994-55-5
• 化学式: C₁₃H₂₀Br₂O₆
• 分子量: 432.106
• InChiKey: RUJXNMBCLDFVSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  bis[2,2-(2-bromoisobutyryl)hydroxymethyl]propionic acid 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 生成 2,2-bis(2-bromo-2-methylpropanoyloxymethyl)propanoyl chloride
  参考文献：
  名称：

  Photochromic Polymer Conjugates: The Importance of Macromolecular Architecture in Controlling Switching Speed within a Polymer Matrix

  摘要：

  Naphthopyran-poly(n-butyl acrylate) conjugates with different geometries were assembled using ATRP. First, within a rigid lens matrix, all investigation of the photochromic behavior of various poly(n-butyl acrylate), p(n-BA), homopolymers showed that midplacement of a single dye moiety, made possible using a Y-branching difunctional photochromic initiator, gave superior fade kinetics per chain length of conjugated polymer compared to end-functionalized homopolymers. Furthermore, having the dye pendant from the chain opposed to directly within the chain was also found to be advantageous. Fading kinetics became faster when chain length was increased, except in the case of linear random copolymers made by copolymerization of n-butyl acrylate with a naphthopyran acrylate. A gradient copolymer made with a nonphotochromic difunctional initiator and a naphthopyran methacrylate displayed Superior kinetics. Films consisting or ABA triblock copolymers, incorporating the photochromic in the middle of a sort p(n-BA) section, gave slower switching speeds compared to lens samples, with responses that were highly tunable and dependent on the amount of soft section inhabited by the photochromic moiety.

  DOI：

  10.1021/ma901830b
• 作为产物：
  描述：

  2-溴-2-甲基丙酰溴 、 2,2-二羟甲基丙酸 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 bis[2,2-(2-bromoisobutyryl)hydroxymethyl]propionic acid
  参考文献：
  名称：

  基于主体-客体化学及其自组装合成智能的Janus样超分子聚合物†

  摘要：

  我们报道了基于宿主-客体化学的Janus样超分子聚合物的双重刺激响应自组装。它是由具有金刚烷（Ad）基团的超支的PMAA和具有β-环糊精（β-CD）基团的超支的PNIPAAm之间的非共价偶联而构建的。在调节溶液的pH或温度时，超分子聚合物可以在溶液中可逆地自组装。

  DOI：

  10.1039/c5ta03937a

文献信息

• HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS
  申请人：Oligasis

  公开号：US20140024776A1

  公开（公告）日：2014-01-23

  The present invention provides multi-armed high MW polymers containing hydrophilic groups and one or more functional agents, and methods of preparing such polymers.

  本发明提供了含有亲水基团和一种或多种功能剂的多臂高分子量聚合物，以及制备这种聚合物的方法。
• Synthesis of supramolecular polymer based on noncovalent “host–guest” inclusion complexation and its reversible self-assembly
  作者：Long Yang、Ming Lei、Min Zhao、Hong Yang、Kehu Zhang、Hong Zhang、Yan Li、Zhongli Lei

  DOI：10.1039/c6nj00728g

  日期：——

  A stimuli-responsive supramolecular polymer based on noncovalent “host–guest” inclusion complexation.

  基于非共价“宿主-客体”包合络合作用的刺激响应性超分子聚合物。
• Photochromic Compounds Comprising Polymeric Substituents And Methods For Preparation And Use Thereof
  申请人：Evans Richard Alexander

  公开号：US20090093601A1

  公开（公告）日：2009-04-09

  The present invention relates to a compound comprising a photochromic moiety and at least one substituent comprising a polymer chain having a carbon backbone and a plurality of functional moieties appended to the carbon backbone.

  本发明涉及一种化合物，该化合物包括一个光致变色基团和至少一个取代基，该取代基包括具有碳骨架的聚合物链和附加到碳骨架上的多个功能基团。
• MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES
  申请人：Charles Stephen A.

  公开号：US20130045522A1

  公开（公告）日：2013-02-21

  The present invention provides random copolymers containing zwitterions and one or more functional agents, and methods of preparing such random copolymers.

  本发明提供了含有双离子和一个或多个功能性试剂的随机共聚物，以及制备这种随机共聚物的方法。
• Stepwise Cleavable Star Polymers and Polymeric Gels Thereof
  作者：Xiubo Jiang、Yongming Chen、Fu Xi

  DOI：10.1021/ma101460n

  日期：2010.9.14

  A multifunctional initiator 1 with chemically labile disulfide and ester groups bearing four bromoisobutyryl groups was prepared by esterification of bis(2-hydroxyethyl)disulfide with 2,2-bis(2-bromoisobutyroyloxymethyl)propionic acid. Then well-defined four-arm star polystyrenes, (S)4, were synthesized by atom transfer radical polymerization of styrene initiated with I. Owing to the presence of the S S and the ester linkages in precisely controlled position of the (S)4 core inherited from the initiator, such a star polystyrene demonstrated interesting stepwise cleavage properties dependent upon the applied conditions. When treating samples with tri-n-butylphosphine or dithiothreitol 2,3-dihydroxy-1,4-butanethiol, the disulfide linkage which located in the center of the star polymers was cleaved and, as a result, one star molecule (S)4 was cut into two linear polystyrenes, 2(S-n)(2), with a -SH group situated in the middle of chains. Then, the resulted (S), could be further cleaved into two shorter polystyrenes, 2(S-n)(1) by hydrolysis to cut two ester groups located in the middle of the PS chains with KOH in a solution of THF/EtOH. Moreover, the (S-n)(4) stars may also be decomposed into the shortest segment, 4(S-n)(1) directly by applying the hydrolysis condition. Furthermore, a polymer organogel was obtained from the cleavable star polymers (S)4 by subjecting atom transfer radical coupling reaction which occurred between their -Br arm ends that preserved during formation of the star polymers. This gel could be also decomposed into the linear polystyrene segments of different length by breaking disulfide and ester linkages, respectively.