2-(4-甲酰基苯氧基)丙酸乙酯 | 51264-73-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(4-甲酰基苯氧基)丙酸乙酯
• 中文别名: 乙基2-(4-甲酰基苯氧基)丙酸盐
• 英文名称: Ethyl-2-(4-formylphenoxy)propionat
• 英文别名: ethyl 2-(4-formylphenoxy)propionate；ethyl 2-(4-formylphenoxy)propanoate
• CAS: 51264-73-4
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: LGKWYOQEGGBNPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  2-(4-甲酰基苯氧基)丙酸乙酯 在 sodium tetrahydroborate 、 氯化亚砜 、 苄基三乙基氯化铵 、 potassium carbonate 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 13.0h， 生成 Ethyl-2-<(4-chlorphenoxymethyl)phenoxy>-propionat
  参考文献：
  名称：

  Koch, Manfred; Bieringer, Hermann, Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1982, vol. 37, # 9, p. 1201 - 1204

  摘要：

  DOI：
• 作为产物：
  描述：

  对羟基苯甲醛 、 2-溴丙酸乙酯 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 2-(4-甲酰基苯氧基)丙酸乙酯
  参考文献：
  名称：

  Indole-Based Fibrates as Potential Hypolipidemic and Antiobesity Agents

  摘要：

  Hypolipidemic and antiobesity effects of the newly synthesized indole-based fibrates were evaluated in Triton WR-1339 and high fat diet (HFD)-induced hyperlipidemic rats. Preliminary screening of all the synthesized compounds was done by using an acute model (Triton model), in which compounds 3f and 3l showed significant antidyslipidemic activity. Furthermore, these compounds 3f and 3l were found to induce significant weight loss in the visceral fat mass of HFD-fed hyperlipidemic rats without affecting the normal feeding behavior. Histological examination of the liver of rats supplemented with 3f and 3l revealed a significant decrease in steatosis when compared to the effect of the standard drug fenofibrate. Additional effects such as an increase in lecithin cholesterol acyl-transferase (LCAT) enzyme level and increased receptor mediated catabolism of I-131-low density lipoproteins (LDL) confirm and reinforce the efficacy of both of these compounds as a new class of dual-acting hypolipidemic and antiobesity agents.

  DOI：

  10.1021/jm201697v

文献信息

• [EN] HYPOPHOSPHOROUS ACID DERIVATIVES HAVING ANTIHYPERALGIC ACTIVITY AND BIOLOGICAL APPLICATIONS THEREOF<br/>[FR] DÉRIVÉS DE L'ACIDE HYPOPHOSPHOREUX AYANT UNE ACTIVITÉ ANTIHYPERALGIQUE ET LEURS APPLICATIONS BIOLOGIQUES
  申请人：UNIV PARIS DESCARTES

  公开号：WO2012156931A1

  公开（公告）日：2012-11-22

  The invention relates to hypophosphorous acid derivatives of formula (I) wherein - X is H or OH, - R represents one or several radicals R1-R5, identical or different, two of R1-R5 optionally occupying the same position on the phenyl group, one to four of R1-R5 being H and the others being selected in the group comprising - 0-(CH2)n-COOH; - S-(CH2)n-COOH; -NH-(CH2)n-COOH; - 0-(CH,R') -COOH; -O- (CH2)n-OH; OR', -R' being a C1 -C3 alkyl radical;-OH; --COOH; halogen, particularly -F, - CI, -Br, -I, -CF3; -OCF3; -N02; -CH=CH-COOH; - -(CH2)n-COOH; O - (CH2)n- P03H2; O - (CF2)n- P03H2; O - (CH2)n- S03H; O - (CH2)n- CONHOH; O - (CH2)n-tetrazol; O - (CH2)n-hydroxyisoxazol - n = 1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers.

  该发明涉及式(I)的次磷酸衍生物，其中- X为H或OH，- R代表一个或几个基团R1-R5，相同或不同，R1-R5中的两个可以选择占据苯基上的同一位置，R1-R5中的一到四个为H，其余的选择自-0-(CH2)n-COOH；-S-(CH2)n-COOH；-NH-(CH2)n-COOH；-0-(CH,R')-COOH；-O-(CH2)n-OH；OR'，其中-R'为C1-C3烷基基团；-OH；-COOH；卤素，特别是-F，-Cl，-Br，-I，-CF3；-OCF3；-NO2；-CH=CH-COOH；-(CH2)n-COOH；O-(CH2)n-P03H2；O-(CF2)n-P03H2；O-(CH2)n-S03H；O-(CH2)n-CONHOH；O-(CH2)n-四唑；O-(CH2)n-羟基异噁唑-n=1至5，优选1-3；所述的次磷酸衍生物为对映异构体或对映体。
• Substituted-phenyl substituted-alkyl ethers and the preparation thereof
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04214094A1

  公开（公告）日：1980-07-22

  The present invention relates to new substituted-phenyl substituted-alkyl ethers and pharmaceutically acceptable salts thereof, which have hypolipidemic activity, and to processes for the preparation thereof, the compound having the following formula ##STR1## wherein R.sub.1 is lower alkyl, cycloalkyl, aryl, ar(lower)alkyl, a heterocyclic group or a group represented by the formula: ##STR2## wherein R.sub.3 and R.sub.4 are each hydrogen or lower alkyl, R.sub.5 is carboxy, esterified carboxy or hydroxymethyl and A is lower alkylene; R.sub.2 is hydrogen, lower alkyl, cycloalkyl, aryl, ar(lower)alkyl, a heterocyclic group or a group represented by the formula: ##STR3## and R.sub.6 is hydrogen, hydroxy or lower alkoxy; in which the aryl or the ar(lower)alkyl for R.sub.1 and R.sub.2 may be substituted with halogen, hydroxy or lower alkoxy, and when R.sub.1 and R.sub.2 are both lower alkyl, R.sub.1 and R.sub.2 may be linked together.

  本发明涉及新的取代苯基取代烷基醚及其药用盐，具有降脂活性，并涉及其制备方法，该化合物具有以下结构式 其中R.sub.1为较低烷基，环烷基，芳基，芳基(较低)烷基，杂环基团或由以下结构式表示的基团： 其中R.sub.3和R.sub.4各自为氢或较低烷基，R.sub.5为羧基，酯化羧基或羟甲基，A为较低烷基；R.sub.2为氢，较低烷基，环烷基，芳基，芳基(较低)烷基，杂环基团或由以下结构式表示的基团： R.sub.6为氢，羟基或较低烷氧基；其中R.sub.1和R.sub.2的芳基或芳基(较低)烷基可以被卤素，羟基或较低烷氧基取代，当R.sub.1和R.sub.2都是较低烷基时，R.sub.1和R.sub.2可以连接在一起。
• Process for producing 2-(4-hydroxyphenoxy) propionate derivatives
  申请人：Nissan Chemical Industries Ltd.

  公开号：US04537984A1

  公开（公告）日：1985-08-27

  A process for producing a 2-(4-hydroxyphenoxy) propionate derivative represented by the formula: ##STR1## where Alk is a C.sub.1 -C.sub.5 alkyl group, which comprises reacting a phenoxy propionate derivative represented by the formula: ##STR2## where Alk is as defined above, with a peroxide to obtain a formate derivative represented by the formula: ##STR3## where Alk is as defined above, and hydrolyzing the formate of the formula III.

  一种生产2-(4-羟基苯氧基)丙酸酯衍生物的方法，其化学式为：##STR1##其中Alk是C.sub.1-C.sub.5烷基，包括将一个化学式为：##STR2##其中Alk如上所定义的苯氧丙酸酯衍生物与过氧化物反应以获得一个甲酸酯衍生物，其化学式为：##STR3##其中Alk如上所定义，并水解化学式III的甲酸酯。
• HYPOPHOSPHOROUS ACID DERIVATIVES HAVING ANTIHYPERALGIC ACTIVITY AND BIOLOGICAL APPLICATIONS THEREOF
  申请人：Acher Francine

  公开号：US20140107078A1

  公开（公告）日：2014-04-17

  The invention relates to hypophosphorous acid derivatives of formula (I) wherein —X is H or OH, —R represents one or several radicals R 1 -R 5 , identical or different, two of R 1 -R 5 optionally occupying the same position on the phenyl group, one to four of R 1 -R 5 being H and the others being selected in the group comprising -0-(CH 2 ) n —COOH; —S—(CH 2 ) n —COOH; —NH—(CH 2 ) n —COOH; -0-(CH,R′)—COOH; —O—(CH 2 ) n —OH; OR′, —R′ being a C 1 -C 3 alkyl radical; —OH; —COOH; halogen, particularly —F, —CI, —Br, —I, —CF 3 ; —OCF 3 ; —N0 2 ; —CH═CH—COOH; —(CH 2 ) n —COOH; O—(CH 2 ) n —P0 3 H 2 ; O—(CF 2 ) n —P0 3 H 2 ; O—(CH 2 ) n —S0 3 H; O—(CH 2 ) n —CONHOH; O—(CH 2 ) n -tetrazol; O—(CH 2 ) n -hydroxyisoxazol—n=1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers.

  本发明涉及公式（I）的亚磷酸衍生物，其中—X为H或OH，—R代表一个或多个基团R1-R5，相同或不同，其中R1-R5中的两个可选择占据苯基上的相同位置，其中一到四个R1-R5是H，其余的被选在包括-0-（CH2）n-COOH；—S-（CH2）n-COOH；—NH-（CH2）n-COOH；-0-（CH，R′）-COOH；—O-（CH2）n-OH；OR′，其中R′是C1-C3烷基基团；—OH；—COOH；卤素，特别是—F，—CI，—Br，—I，—CF3；—OCF3；—N02；—CH═CH—COOH；—（CH2）n-COOH；O-（CH2）n-P03H2；O-（CF2）n-P03H2；O-（CH2）n-S03H；O-（CH2）n-CONHOH；O-（CH2）n-四唑；O-（CH2）n-羟基异噁唑-n=1至5，优选1-3；所述亚磷酸衍生物为对映异构体或对映体。
• Hypophosphorous acid derivatives having antihyperalgic activity and biological applications thereof
  申请人：Acher Francine

  公开号：US09212196B2

  公开（公告）日：2015-12-15

  The invention relates to hypophosphorous acid derivatives of formula (I) wherein —X is H or OH, —R represents one or several radicals R1-R5, identical or different, two of R1-R5 optionally occupying the same position on the phenyl group, one to four of R1-R5 being H and the others being selected in the group comprising -0-(CH2)n—COOH; —S—(CH2)n—COOH; —NH—(CH2)n—COOH; -0-(CH,R′)—COOH; —O—(CH2)n—OH; OR′, —R′ being a C1-C3 alkyl radical; —OH; —COOH; halogen, particularly —F, —CI, —Br, —I, —CF3; —OCF3; —N02; —CH═CH—COOH; —(CH2)n—COOH; O—(CH2)n—P03H2; O—(CF2)n—P03H2; O—(CH2)n—S03H; O—(CH2)n—CONHOH; O—(CH2)n-tetrazol; O—(CH2)n-hydroxyisoxazol—n=1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers.

  本发明涉及式(I)的亚磷酸衍生物，其中-X为H或OH，-R代表一个或几个基团R1-R5，相同或不同，其中R1-R5中的两个可以选择占据苯基上的同一位置，R1-R5中的1-4个为H，其余的被选择在包括-0-(CH2)n-COOH；-S-(CH2)n-COOH；-NH-(CH2)n-COOH；-0-(CH，R′)-COOH；-O-(CH2)n-OH；OR′；-R′为C1-C3烷基基团；-OH；-COOH；卤素，特别是-F，-CI，-Br，-I，-CF3；-OCF3；-N02；-CH═CH-COOH；-(CH2)n-COOH；O-(CH2)n-P03H2；O-(CF2)n-P03H2；O-(CH2)n-S03H；O-(CH2)n-CONHOH；O-(CH2)n-四唑；O-(CH2)n-羟基异噁唑-n=1-5，优选1-3；所述亚磷酸衍生物为对映异构体或对映体。