7-oxa-8,10-dioxoundecyl 2-methyl-4-(10,10-diphenyl-9-decenyl)-5,5-diphenyl-4,5-dihydrofuran-3-carboxylate | 1224127-94-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-oxa-8,10-dioxoundecyl 2-methyl-4-(10,10-diphenyl-9-decenyl)-5,5-diphenyl-4,5-dihydrofuran-3-carboxylate
• CAS: 1224127-94-9
• 化学式: C₅₀H₅₈O₆
• 分子量: 755.007
• InChiKey: QKYYBUWXOJLHNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.73
• 重原子数：
  56.0
• 可旋转键数：
  23.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  78.9
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  7-oxa-8,10-dioxoundecyl 2-methyl-4-(10,10-diphenyl-9-decenyl)-5,5-diphenyl-4,5-dihydrofuran-3-carboxylate 在 manganese(III) triacetate dihydrate 、 溶剂黄146 作用下， 反应 0.12h， 以78%的产率得到13,28-dimethyl-3,10,14,27-tetraoxa-2,11-dioxo-15,15,26,26-tetraphenyltricyclo[23.3.0.0(12,16)]octacosa-12,28-diene
  参考文献：
  名称：

  Efficient macrocyclization using methylene-tethered terminal dienes and bis(manganese(III)-enolate)s

  摘要：

  Macrocyclic compounds, which have two fused dihydrofuran rings, were synthesized with complete control by the oxidation of alpha,alpha,omega,omega-tetraaryl-alpha(omega-1)-alkadienes 1(x) with manganese(III)-oligomethylenebis(enolate) complexes directly formed by the reaction of the ohgomethylene bis(3-oxobutanoate)s 2(y) with manganese(III) acetate in situ The oxamethylene-tethered macrodiolides 5 and 7 were also produced in good to moderate yields by a similar oxidation The key intermediate, an election donor-acceptor-like complex, was proposed for the efficient macrocyclization reaction (C) 2010 Elsevier Ltd. All rights reserved

  DOI：

  10.1016/j.tet.2010.02.022
• 作为产物：
  描述：

  双乙烯酮 、 6-hydroxyhexyl 4-(10,10-diphenyldec-9-en-1-yl)-2-methyl-5,5-diphenyl-4,5-dihydrofuran-3-carboxylate 在 咪唑 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以66%的产率得到7-oxa-8,10-dioxoundecyl 2-methyl-4-(10,10-diphenyl-9-decenyl)-5,5-diphenyl-4,5-dihydrofuran-3-carboxylate
  参考文献：
  名称：

  Efficient macrocyclization using methylene-tethered terminal dienes and bis(manganese(III)-enolate)s

  摘要：

  Macrocyclic compounds, which have two fused dihydrofuran rings, were synthesized with complete control by the oxidation of alpha,alpha,omega,omega-tetraaryl-alpha(omega-1)-alkadienes 1(x) with manganese(III)-oligomethylenebis(enolate) complexes directly formed by the reaction of the ohgomethylene bis(3-oxobutanoate)s 2(y) with manganese(III) acetate in situ The oxamethylene-tethered macrodiolides 5 and 7 were also produced in good to moderate yields by a similar oxidation The key intermediate, an election donor-acceptor-like complex, was proposed for the efficient macrocyclization reaction (C) 2010 Elsevier Ltd. All rights reserved

  DOI：

  10.1016/j.tet.2010.02.022