3-[9-(3-Hydroxypropyl)-4,12-dimethoxy-8,16,17-trioxatetracyclo[7.7.1.02,7.010,15]heptadeca-2(7),3,5,10(15),11,13-hexaen-1-yl]propan-1-ol | 274910-44-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-[9-(3-Hydroxypropyl)-4,12-dimethoxy-8,16,17-trioxatetracyclo[7.7.1.02,7.010,15]heptadeca-2(7),3,5,10(15),11,13-hexaen-1-yl]propan-1-ol
• CAS: 274910-44-0
• 化学式: C₂₂H₂₆O₇
• 分子量: 402.444
• InChiKey: HURKZPFGBGTHGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  86.6
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3-[9-(3-Hydroxypropyl)-4,12-dimethoxy-8,16,17-trioxatetracyclo[7.7.1.02,7.010,15]heptadeca-2(7),3,5,10(15),11,13-hexaen-1-yl]propan-1-ol 在 jones' reagent 作用下， 以 丙酮 为溶剂， 反应 0.17h， 以95%的产率得到3-[9-(2-Carboxyethyl)-4,12-dimethoxy-8,16,17-trioxatetracyclo[7.7.1.02,7.010,15]heptadeca-2(7),3,5,10(15),11,13-hexaen-1-yl]propanoic acid
  参考文献：
  名称：

  The first total syntheses of (±)-Preussomerins K and L using 2-arylacetal anion technology

  摘要：

  The first syntheses of newly isolated members of the Preussomerin family, Preussomerins K and L, are reported. Key steps include the functionalisation of a 2-arylacetal anion, one-pot Friedel-Crafts cyclisation-deprotection and reductive opening of epoxides. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2004.04.143
• 作为产物：
  描述：

  2-羟基-5-甲氧基苯甲醛 在 硫酸 、 三甲基乙酸酐 作用下， 反应 0.5h， 生成 3-[9-(3-Hydroxypropyl)-4,12-dimethoxy-8,16,17-trioxatetracyclo[7.7.1.02,7.010,15]heptadeca-2(7),3,5,10(15),11,13-hexaen-1-yl]propan-1-ol
  参考文献：
  名称：

  The first total syntheses of (±)-Preussomerins K and L using 2-arylacetal anion technology

  摘要：

  The first syntheses of newly isolated members of the Preussomerin family, Preussomerins K and L, are reported. Key steps include the functionalisation of a 2-arylacetal anion, one-pot Friedel-Crafts cyclisation-deprotection and reductive opening of epoxides. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2004.04.143

文献信息

• The first total syntheses of (±)-Preussomerins K and L using 2-arylacetal anion technology
  作者：Ernesto Quesada、Martin Stockley、Richard J.K Taylor

  DOI：10.1016/j.tetlet.2004.04.143

  日期：2004.6

  The first syntheses of newly isolated members of the Preussomerin family, Preussomerins K and L, are reported. Key steps include the functionalisation of a 2-arylacetal anion, one-pot Friedel-Crafts cyclisation-deprotection and reductive opening of epoxides. (C) 2004 Published by Elsevier Ltd.