4-methoxy-2-nitro-1-propoxy-benzene | 16169-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methoxy-2-nitro-1-propoxy-benzene
• 英文别名: 4-Methoxy-2-nitro-1-propoxy-benzol；2-Nitro-hydrochinon-4-methylaether-1-propylaether；3-Nitro-4-propyloxy-anisol；1-Methoxy-4-propyloxy-3-nitro-benzol；4-methoxy-2-nitro-1-propoxybenzene
• CAS: 16169-28-1
• 化学式: C₁₀H₁₃NO₄
• mdl: MFCD26398511
• 分子量: 211.218
• InChiKey: GXWXLELTQSINRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  64.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲氧基-2-硝基乙酰苯胺 在 sodium hydroxide 作用下， 生成 4-methoxy-2-nitro-1-propoxy-benzene
  参考文献：
  名称：

  Nishino et al., Yuki Gosei Kagaku Kyokaishi, 1959, vol. 17, p. 166,169

  摘要：

  DOI：

文献信息

• 2, 4-Pyrimidinediamines Useful In The Treatment Of Neoplastic Diseases, Inflammatory And Immune System Disorders
  申请人：Garcia-Echeverria Carlos

  公开号：US20080132504A1

  公开（公告）日：2008-06-05

  Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them

  式I的新型嘧啶衍生物及其制备方法，它们的药用价值以及包含它们的药物组合物。
• PYRIMIDINE DERIVATIVES
  申请人：Garcia-Echeverria Carlos

  公开号：US20110201606A1

  公开（公告）日：2011-08-18

  Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them

  式I的新型嘧啶衍生物及其制备方法，其用作药物和含有它们的药物组合物。
• 2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS
  申请人：Garcia-Echeverria Carlos

  公开号：US20110098280A1

  公开（公告）日：2011-04-28

  Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

  I类新型嘧啶衍生物的制备方法，以及它们作为药物和药物组合物的用途。
• 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders.
  申请人：Novartis AG

  公开号：EP2275413A1

  公开（公告）日：2011-01-19

  Novel pyrimidine derivatives of formula (I), to processes for their production, their use as IGF-1R and ALK-inhibitors in the treatment of neoplastic diseases, inflammatory and immune system disorders and to pharmaceutical compositions comprising them.

  式（I）的新型嘧啶衍生物，其生产工艺，在治疗肿瘤性疾病、炎症和免疫系统疾病中作为 IGF-1R 和 ALK 抑制剂的用途，以及包含它们的药物组合物。
• 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
  申请人：Novartis AG

  公开号：EP2287156A1

  公开（公告）日：2011-02-23

  Novel pyrimidine derivatives of formula (I) and their use for the manufacture of a medicament for the treatment or prevention of a disease which responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR. in which: n' is selected from 1,2 and 3; R'1is selected from phenyl, pyridinyl, pyrazolyl and pyrimidinyl; and R'2 and R'3 are as described herein.

  式(I)的新型嘧啶衍生物及其用于制造治疗或预防对抑制FAK和/或ALK和/或ZAP-70和/或IGF-IR有反应的疾病的药物。 其中：n'选自 1、2 和 3； R'1 选自苯基、吡啶基、吡唑基和嘧啶基； 以及 R'2 和 R'3 如本文所述。