(2R,3S)-pterosin C | 68399-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (2R,3S)-pterosin C
• 英文别名: (2R,3S)-3-hydroxy-6-(2-hydroxyethyl)-2,5,7-trimethyl-2,3-dihydroinden-1-one
• CAS: 68399-17-7
• 化学式: C₁₄H₁₈O₃
• 分子量: 234.295
• InChiKey: QQPCNRKHGFIVLH-RNCFNFMXSA-N

物化性质

• 沸点：
  448.2±45.0 °C(Predicted)
• 密度：
  1.202±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 储存条件：
  储存条件：密封、干燥、避光，保存温度为2-8°C。

反应信息

• 作为产物：
  描述：

  (2R,3S)-pterosin C 3-O-β-(4'-p-coumaroyl)-glucopyranoside 在 硫酸 作用下， 反应 0.5h， 生成 可得然胶 、 4-香豆酸 、 (2R,3S)-pterosin C
  参考文献：
  名称：

  Cytotoxic Diterpenoids and Sesquiterpenoids from Pteris multifida

  摘要：

  Three new ent-kaurane diterpenoids, named pterokaurane M-1-M-3 (1-3) and three new C-14 pterosin-sesquiterpenoids, named multifidoside A-C (4-6), along with 18 known compounds, were isolated from the whole plants of Pteris multifida. The structures of 1-6 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Compounds 4 and 5 showed cytotoxicity against the HepG2 tumor cell line with IC50 values of less than 10 mu M.

  DOI：

  10.1021/np0706421

文献信息

• USE OF PTEROSIN COMPOUNDS FOR TREATING DIABETES AND OBESITY
  申请人：Hsu Feng-Lin

  公开号：US20100190732A1

  公开（公告）日：2010-07-29

  This invention relates to the use of pterosin compounds of formula I for treating diabetes including type I and type II. Also disclosed is the use of the pterosin compounds for treating obesity.

  本发明涉及使用式I的翼龙素化合物治疗糖尿病，包括1型和2型糖尿病。还揭示了使用翼龙素化合物治疗肥胖症。
• US8633252B2
  申请人：——

  公开号：US8633252B2

  公开（公告）日：2014-01-21
• Cytotoxic Diterpenoids and Sesquiterpenoids from Pteris multifida
  作者：Xin Ge、Guan Ye、Ping Li、Wen-Jie Tang、Jin-Li Gao、Wei-Min Zhao

  DOI：10.1021/np0706421

  日期：2008.2.1

  Three new ent-kaurane diterpenoids, named pterokaurane M-1-M-3 (1-3) and three new C-14 pterosin-sesquiterpenoids, named multifidoside A-C (4-6), along with 18 known compounds, were isolated from the whole plants of Pteris multifida. The structures of 1-6 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Compounds 4 and 5 showed cytotoxicity against the HepG2 tumor cell line with IC50 values of less than 10 mu M.