3-[2-(5-Methyl-1,3-oxazol)-yl]-1,2,5,6-tetrahydropyridine hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[2-(5-Methyl-1,3-oxazol)-yl]-1,2,5,6-tetrahydropyridine hydrochloride
• 英文别名: 3-(5-methyloxazol-2-yl)-1,2,5,6-tetrahydropyridine hydrochloride；5-Methyl-2-(1,2,3,6-tetrahydropyridin-5-yl)-1,3-oxazole;hydrochloride
• 化学式: C₉H₁₂N₂O*ClH
• 分子量: 200.668
• InChiKey: UKBHSARRDPOLDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.78
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  38.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-methyl-3-[2-(5-methyl-1,3-oxazol)-yl]-1,2,5,6-tetrahydropyridine 、 1-氯乙基氯甲酸酯 以 甲醇 、 二氯甲烷 为溶剂， 生成 3-[2-(5-Methyl-1,3-oxazol)-yl]-1,2,5,6-tetrahydropyridine hydrochloride
  参考文献：
  名称：

  Derivatives of 1,2,5,6-tetrahydropyridine substituted by a thiazolyl or

  摘要：

  化合物的式子(I) ##STR1## 其中X代表氧或硫，R.sub.1代表氢，线性、支链或环烷基，含有高达8个碳原子，烯基或炔基，含有高达6个碳原子，羟基，OCOalk.sub.1基团，其中alk.sub.1代表含有高达6个碳原子的烷基，OCONHalk.sub.2基团，其中alk.sub.2代表含有高达6个碳原子的烷基，CO.sub.2 alk.sub.3基团，其中alk.sub.3代表含有高达6个碳原子的烷基或烯基，Oalk.sub.4基团，其中alk.sub.4代表含有高达6个碳原子的烷基，OCOAr.sub.1，OCONHAr.sub.2或CO.sub.2 Ar.sub.3基团，其中Ar.sub.1，Ar.sub.2或Ar.sub.3代表含有高达14个碳原子的芳基，R.sub.2代表氢，线性、支链或环烷基，含有高达6个碳原子，烯基或炔基，含有高达6个碳原子，alkoxyalkyl alk'.sub.1 Oalk'.sub.2基团，其中alk'.sub.1和alk'.sub.2代表含有高达6个碳原子的烷基，含有高达6个碳原子的烷基的羟基烷基或含有高达14个碳原子的芳基，以及它们与有机或无机酸的加成盐，这些化合物在治疗患有阿尔茨海默病、老年性痴呆或老年人记忆障碍的患者中有用；此外，还包括含有相同化合物的组合物，使用方法，制备方法和中间体。

  公开号：

  US05053416A1

文献信息

• Oxazoles and thiazoles for the treatment of senile dementia
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP0307141B1

  公开（公告）日：1993-01-13
• US5053416A
  申请人：——

  公开号：US5053416A

  公开（公告）日：1991-10-01
• US5324723A
  申请人：——

  公开号：US5324723A

  公开（公告）日：1994-06-28
• Derivatives of 1,2,5,6-tetrahydropyridine substituted by a thiazolyl or
  申请人：Roussel Uclaf

  公开号：US05053416A1

  公开（公告）日：1991-10-01

  Compounds of formula (I) ##STR1## in which X represents oxygen or sulphur, R.sub.1 represents hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms, an alkenyl or alkynyl containing up to 6 carbon atoms, hydroxyl, an OCOalk.sub.1 radical in which alk.sub.1 represents alkyl containing up to 6 carbon atoms, an OCONHalk.sub.2 radical in which alk.sub.2 represents alkyl containing up to 6 carbon atoms, a CO.sub.2 alk.sub.3 radical in which alk.sub.3 represents alkyl or alkenyl containing up to 6 carbon atoms, an Oalk.sub.4 radical in which alk.sub.4 represents alkyl containing up to 6 carbon atoms, an OCOAr.sub.1, OCONHAr.sub.2 or CO.sub.2 Ar.sub.3 radical in which Ar.sub.1, Ar.sub.2 or Ar.sub.3 represents aryl containing up to 14 carbon atoms, R.sub.2 represents hydrogen, a linear, branched or cyclic alkyl containing up to 6 carbon atoms, alkenyl or alkynyl containing up to 6 carbon atoms, an alkoxyalkyl alk'.sub.1 Oalk'.sub.2 radical in which alk'.sub.1 and alk'.sub.2 represent alkyl containing up to 6 carabon atoms, hydroxyalkyl in which the alkyl contains up to 6 carbon atoms or aryl containing up to 14 carbon atoms, as well as their addition salts with organic or mineral acids, which compounds are useful in the treatment of patients suffering from Alzheimer's disease, senile dementia or memory disorders of the aged; also, compositions containing the same, method of use, method of preparation, and intermediates therefor.

  化合物的式子(I) ##STR1## 其中X代表氧或硫，R.sub.1代表氢，线性、支链或环烷基，含有高达8个碳原子，烯基或炔基，含有高达6个碳原子，羟基，OCOalk.sub.1基团，其中alk.sub.1代表含有高达6个碳原子的烷基，OCONHalk.sub.2基团，其中alk.sub.2代表含有高达6个碳原子的烷基，CO.sub.2 alk.sub.3基团，其中alk.sub.3代表含有高达6个碳原子的烷基或烯基，Oalk.sub.4基团，其中alk.sub.4代表含有高达6个碳原子的烷基，OCOAr.sub.1，OCONHAr.sub.2或CO.sub.2 Ar.sub.3基团，其中Ar.sub.1，Ar.sub.2或Ar.sub.3代表含有高达14个碳原子的芳基，R.sub.2代表氢，线性、支链或环烷基，含有高达6个碳原子，烯基或炔基，含有高达6个碳原子，alkoxyalkyl alk'.sub.1 Oalk'.sub.2基团，其中alk'.sub.1和alk'.sub.2代表含有高达6个碳原子的烷基，含有高达6个碳原子的烷基的羟基烷基或含有高达14个碳原子的芳基，以及它们与有机或无机酸的加成盐，这些化合物在治疗患有阿尔茨海默病、老年性痴呆或老年人记忆障碍的患者中有用；此外，还包括含有相同化合物的组合物，使用方法，制备方法和中间体。