1-(氨基甲基)环己烷羧酸 | 227203-35-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1-(氨基甲基)环己烷羧酸
• 英文名称: 1-(aminomethyl)-cyclohexaneacetic acid
• 英文别名: trans aminomethylcyclohexanecarboxylic acid；1-(Aminomethyl)cyclohexane-1-carboxylic acid
• CAS: 227203-35-2
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: UAFHRUBCOQPFFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(氨基甲基)环己烷羧酸 在 硼烷四氢呋喃络合物 、 甲醇 作用下， 以 四氢呋喃 为溶剂， 反应 13.5h， 以1.1 g的产率得到1-(氨基甲基)环己烷甲醇
  参考文献：
  名称：

  一种2-取代的高牛磺酸衍生物

  摘要：

  本发明提供了一种2‑取代高牛磺酸衍生物或其立体异构体或盐的制备及应用。所述2‑取代高牛磺酸衍生物如式I所示，经药效试验表明，本发明的2‑取代的高牛磺酸衍生物的酒精抑制作用效果优异，有着理想的酒精抑制类药物的应用前景。

  公开号：

  CN110668980A
• 作为产物：
  描述：

  1-(氨基甲基)环己基羧酸甲酯 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 1-(氨基甲基)环己烷羧酸
  参考文献：
  名称：

  Preparation and Structure ofβ-Peptides Consisting of Geminally Disubstitutedβ2,2- andβ3,3-Amino Acids: A Turn Motif forβ-Peptides

  摘要：

  We report on the synthesis of new and previously described beta-peptides (1-6), consisting of up to twelve beta(2,2-) or beta(3,3)-geminally disubstituted beta-amino acids which do not fit into any of the secondary structural patterns of beta-peptides, hitherto disclosed. The required 2,2- and 3,3-dimethyl derivatives of 3-aminopropanoic acid are readily obtained from 3-methylbut-2-enoic acid and ammonia (Scheme 1) and from Boc-protected methyl 3-aminopropanoate by enolate methylation (Scheme 2). Protected (Boc for solution-, Fmoc for solid-phase syntheses) 1-(aminomethyl)cycloalkanecarboxylic-acid derivatives (with cyclopropane, cyclobutane, cyclopentane, and cyclohexane rings) are obtained from 1-cyanocycloalkanecarboxylates and the corresponding dihaloalkanes (Scheme 3). Fully C-13- and N-15-labeled 3-amino-2,2-dimethylpropanoic-acid derivatives were prepared from the corresponding labeled precursors (see asterixed formula numbers and Scheme 4). Coupling of these amino acids was achieved by methods which we had previously employed for other beta-peptide syntheses ( intermediates 18 - 23). Crystal structures of Boc-protected geminally disubstituted amine acids (16a-d) and of the corresponding tripeptide (23a), as well as NMR and IR spectra of an isotopically labeled beta-hexapeptide (2a*) are presented (Figs. 1-4) and discussed. The tripeptide structure contains a ten-membered H-bonded ring which is proposed to be a turn-forming motif for beta-peptides (Fig. 2).

  DOI：

  10.1002/(sici)1522-2675(19981216)81:12<2218::aid-hlca2218>3.0.co;2-0

文献信息

• Amides, useful in the inhibition of il-8-induced chemotaxis of neutrophils
  申请人：——

  公开号：US20040181073A1

  公开（公告）日：2004-09-16

  N-(2-aryl-propionyl)-amides of formula (I) are described. 1 The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear neutrophils (leukocytes PMN) at the inflammatory sites. In particular, the invention relates to the R enantiomers of N-(2-aryl-propionyl)amides of formula (I) for use in the ihibition of the chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, and rheumatoid arthritis.

  公式（I）的N-（2-芳基丙酰基）酰胺已被描述。还描述了它们的制备过程和药物制剂。本发明的酰胺在预防和治疗由于在炎症部位加重多形核中性粒细胞（白细胞PMN）的招募而导致的组织损伤方面是有用的。具体而言，本发明涉及用于抑制IL-8诱导的中性粒细胞趋化作用的N-（2-芳基丙酰基）酰胺的R对映体。本发明的化合物用于治疗牛皮癣、溃疡性结肠炎、肾小球肾炎、急性呼吸功能不全、特发性纤维化和类风湿关节炎。
• EIF4E BINDING PEPTIDES
  申请人：Agency for Science, Technology and Research

  公开号：US20160038567A1

  公开（公告）日：2016-02-11

  The present invention relates to modified eIF4G1 peptides, uses thereof and pharmaceutical compositions comprising the modified eIF4G1 peptides.

  本发明涉及改良的eIF4G1肽，其用途以及包含改良的eIF4G1肽的药物组合物。
• Derivatives of aminomethylcyclohexanecarboxylic acid
  申请人：Rorer Italiana S.p.A.

  公开号：US04055580A1

  公开（公告）日：1977-10-25

  The present invention is concerned with new derivatives of transaminomethylcyclohexanecarboxylic acid, which possess an anti-toxic, anti-hyperlipidic, anti-atherosclerosis, anti-phlogistic and gastroprotective activity. The compounds of the invention are represented by the general formula : ##STR1## in which : R is a group C.sub.n H.sub.2n+n' --CO-- n is an integer from 4 to 20, n' is +1, -1, -3 or -5, and R' is hydrogen or an alkyl group having 1 to 6 carbon atoms.

  该发明涉及新的氨基甲基环己烷羧酸衍生物，具有抗毒性、抗高脂血症、抗动脉粥样硬化、抗炎和胃保护活性。该发明的化合物由以下通式表示：##STR1## 其中：R是一个C.sub.n H.sub.2n+n' --CO--基团，n是从4到20的整数，n'是+1、-1、-3或-5，R'是氢或具有1到6个碳原子的烷基基团。
• beta-sheet mimetics and composition and methods relating thereto
  申请人：Myriad Pharmaceuticals, Inc.

  公开号：US20040014763A1

  公开（公告）日：2004-01-22

  Compounds having the following structure: 1 including pharmaceutically acceptable salts and stereoisomers thereof, wherein A, A′, B, X, Y, R 2 , R 3 , R 4 and R 5 are as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing such compounds, are tryptase antagonists.

  具有以下结构的化合物：1，包括药用可接受的盐及其立体异构体，其中A、A'、B、X、Y、R2、R3、R4和R5如本文所定义。这些化合物在广泛的应用范围内具有实用性，包括用作诊断和治疗剂。特别是，本发明的化合物和含有这些化合物的药物组合物是色胺酸蛋白酶抑制剂。
• [EN] PROSTATE-SPECIFIC MEMBRANE ANTIGEN TARGETED HIGH-AFFINITY AGENTS FOR ENDORADIOTHERAPY OF PROSTATE CANCER<br/>[FR] AGENTS À AFFINITÉ ÉLEVÉE CIBLANT UN ANTIGÈNE MEMBRANAIRE SPÉCIFIQUE DE LA PROSTATE POUR ENDORADIOTHÉRAPIE DU CANCER DE LA PROSTATE
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2018222778A1

  公开（公告）日：2018-12-06

  Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer are disclosed.

  揭示了针对前列腺癌的内放射治疗的前列腺特异性膜抗原靶向高亲和力药物。