苯丙氨酸酰肼 | 21820-50-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 苯丙氨酸酰肼
• 英文名称: DL-phenylalanine hydrazide
• 英文别名: DL-Phenylalanin-hydrazid；2-Amino-3-phenylpropanehydrazide
• CAS: 21820-50-8
• 化学式: C₉H₁₃N₃O
• 分子量: 179.222
• InChiKey: UHYBQLHLHAROJR-UHFFFAOYSA-N

物化性质

• 熔点：
  82-84 °C
• 沸点：
  410.0±38.0 °C(Predicted)
• 密度：
  1.175±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  81.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  苯丙氨酸酰肼 生成 2-amino-3-phenylpropionic acid hydrazide
  参考文献：
  名称：

  Losse et al., Journal fur praktische Chemie (Leipzig 1954), 1959, vol. <4> 8, p. 339,342

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基 3-苯基-DL-丙氨酸酯 在 乙醇 、 一水合肼 作用下， 生成 苯丙氨酸酰肼
  参考文献：
  名称：

  The Apparent Ionization Constants of a Series of Phenylalanine Derivatives¹

  摘要：

  DOI：

  10.1021/ja01520a061

文献信息

• Ultrasonication-enhanced gelation properties of a versatile amphiphilic formamidine-based gelator exhibiting both organogelation and hydrogelation abilities
  作者：Jürgen Bachl、Diego Sampedro、Judith Mayr、David Díaz Díaz

  DOI：10.1039/c7cp03529b

  日期：——

  temperature, viscoelastic moduli) in comparison to the heating-cooling protocol typically used to obtain supramolecular gels. Thermoreversibility, thixotropy, injectability and multistimuli responsiveness are some of the most relevant functionalities of these gels. Electron microscopy imaging revealed the formation of entangled networks made of fibers of nanometer 15 diameters and micrometer lengths, with different

  我们描述了一种由甲phi核构建的新型两亲胶凝剂的制备，该胶凝剂能够形成浓度范围为15–150 mg / mL的各种物理有机凝胶和水凝胶。有趣的是，对各向同性溶液（即凝胶前体）进行超声处理可显着提高凝胶动力学，凝胶作用范围和特性凝胶特性（例如，临界凝胶浓度，凝胶至溶胶转变温度，与通常用于获得超分子凝胶的加热-冷却方案相比）。热可逆性，触变性，可注射性和多刺激响应性是这些凝胶最相关的功能。电子显微镜成像揭示了由纳米15直径和微米长度的纤维制成的缠结网络的形成，其具有取决于溶剂的不同形态特征。从FTIR，NMR，PXRD和计算研究获得了对分子聚集驱动力的见解。结果表明，在π-π堆积相互作用下，通过添加NH·······O氢键以及疏水相互作用，可以使纤维具有较大的稳定性。
• Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives
  作者：Alexander V. Aksenov、Nikita K. Kirilov、Nicolai A. Aksenov、Nikolai A. Arutiunov、Dmitrii A. Aksenov、Michael Rubin

  DOI：10.1007/s10593-022-03053-2

  日期：2022.1

  Novel preparative approach for the synthesis of alkylamines with 1,3,4-oxadiazole heterocyclic substituent is described. This method is based on unusual cascade transformation involving formal (4+1) cyclocondensation of hydrazides of amino acids with nitroalkanes electrophilically activated in the presence of polyphosphoric acid.

  描述了合成具有 1,3,4-恶二唑杂环取代基的烷基胺的新制备方法。该方法基于不寻常的级联转化，包括氨基酸酰肼与硝基烷在多磷酸存在下亲电活化的形式 (4+1) 环缩合。
• DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO-OR NANOEMULSIFICATION
  申请人：Dietz Ulrich

  公开号：US20130090488A1

  公开（公告）日：2013-04-11

  The present invention is directed to solubilizing compounds, a device and a method for solubilizing and removing carboxylic acids and especially fatty acids from oils, fats, aqueous emulsion, aqueous media and organic solutions. Devices utilizing the inventive method shall be used for separating carboxylic acids from oils, fats, aqueous emulsion, lipophilic media or organic solutions, respectively by preparing an aqueous micro- or nanoemulsion of the carboxylic acids especially the fatty acids and the solubilizing compound which contains at least one amidino and/or gianidino group. Solubilization effects of solubilizing compounds combined with the inventive use of separation methods for carboxylic acids can be used to treat persons in need of removal of fatty acids or analyze carboxylic acids from blood or process other solutions in food, pharmacy, chemistry, bio fuel industry or other industrial processings.

  本发明涉及溶解化合物、用于从油、脂肪、水乳液、水介质和有机溶液中溶解和去除羧酸，特别是脂肪酸的装置和方法。采用本发明方法的装置将用于通过制备羧酸特别是脂肪酸和含有至少一种氨基甲酰基和/或肼基团的溶解化合物的水微观或纳米乳液，分离油、脂肪、水乳液、亲脂性介质或有机溶液中的羧酸。溶解化合物的溶解效果与本发明所述的羧酸分离方法相结合，可用于治疗需要去除脂肪酸或从血液中分析羧酸或处理食品、药品、化学、生物燃料工业或其他工业加工过程中的其他溶液的人员。
• Device and method for solubilizing, separating, removing and reacting carboxylic acids in oils, fats, aqueous or organic solutions by means of micro-or nanoemulsification
  申请人：Dietz Ulrich

  公开号：US09127233B2

  公开（公告）日：2015-09-08

  The present invention is directed to solubilizing compounds, a device and a method for solubilizing and removing carboxylic acids and especially fatty acids from oils, fats, aqueous emulsion, aqueous media and organic solutions. Devices utilizing the inventive method shall be used for separating carboxylic acids from oils, fats, aqueous emulsion, lipophilic media or organic solutions, respectively by preparing an aqueous micro- or nanoemulsion of the carboxylic acids especially the fatty acids and the solubilizing compound which contains at least one amidino and/or gianidino group. Solubilization effects of solubilizing compounds combined with the inventive use of separation methods for carboxylic acids can be used to treat persons in need of removal of fatty acids or analyze carboxylic acids from blood or process other solutions in food, pharmacy, chemistry, bio fuel industry or other industrial processings.

  本发明涉及可溶化化合物、用于从油、脂肪、水乳液、水介质和有机溶液中溶解和去除羧酸，特别是脂肪酸的装置和方法。采用本发明方法的装置将用于通过制备羧酸，特别是脂肪酸和含有至少一种酰胺基和/或氨基甲酸基团的可溶化化合物的水微观或纳米乳液，分离油、脂肪、水乳液、亲脂性介质或有机溶液中的羧酸。可溶化化合物的溶解效果与本发明用于羧酸的分离方法相结合，可用于治疗需要去除脂肪酸或分析血液中的羧酸或处理食品、药品、化学品、生物燃料工业或其他工业加工中的其他溶液的人。
• A process for enzymatic production of peptides
  申请人：DE FORENEDE BRYGGERIER A/S

  公开号：EP0017485A1

  公开（公告）日：1980-10-15

  A process for producing a peptide comprises reacting a substrate selected from amino acid esters, peptide esters, depsipeptides, optionally N-substituted amino acid amides and peptide amides, and optionally N-terminal protected peptides, with an amine component selected from amino acids, optionally N-substituted aminoacid amides and amino acid esters in the presence of a carboxypeptidase enzyme in an aqueous solution or dispersion having a pH from 5 to 10.5.

  一种生产肽的工艺包括在 pH 值为 5 至 10.5 的水溶液或分散液中，在羧肽酶的存在下，使选 自氨基酸酯、肽酯、解肽、任选 N-取代氨基酸酰胺和肽酰胺以及任选 N-末端保护肽的底物与选 自氨基酸、任选 N-取代氨基酸酰胺和氨基酸酯的胺组分反应。