1-ethyl-1-methylpropyl acrylate | 336609-22-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-ethyl-1-methylpropyl acrylate
• 英文别名: 3-methylpentan-3-yl prop-2-enoate
• CAS: 336609-22-4
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: VCNYEJFEMXFKTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-ethyl-1-methylpropyl acrylate 、 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-hydroxy-9,10-secopregna-5,7,10(19),16-tetraene 以 四氢呋喃 为溶剂， 生成 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-{2-(1-ethyl-1-methylpropoxycarbonyl)ethoxy}-9,10-secopregna-5,7,10(19),16-tetraene
  参考文献：
  名称：

  VITAMIN D DERIVATIVES POSSESSING A 22-OXA OR 22-THIA ATOM, A C17-SIDE CHAIN SUBSTITUTED BY AN ACID, ESTER OR AMIDE GROUP AND A 16(17)-DOUBLE BOND

  摘要：

  公开号：

  EP1295871B1
• 作为产物：
  描述：

  3-甲基-3-戊醇 、 丙烯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 14.0h， 以63%的产率得到1-ethyl-1-methylpropyl acrylate
  参考文献：
  名称：

  Vitamin d derivatives

  摘要：

  本发明的目的是提供作为药物的维生素D衍生物，特别是作为治疗银屑病等皮肤疾病的治疗剂，并且具有减少高钙血症作用的维生素D衍生物。 本发明提供了化学式（1）的维生素D衍生物： 1 其中 X代表氧原子或硫原子； m代表1至3的数字； R 1 和R 2 分别代表氢原子或烷基； R 4 和R 5 分别代表氢原子或羟基等； R 3 代表—YR 8 等； R 6 代表氢原子等；以及 R 7 代表氢原子等。

  公开号：

  US20040019023A1

文献信息

• PROCESS FOR PREPARING TERTIARY ALKYL ESTERS OF (METH) ACRYLIC ACID HAVING AT LEAST 4 CARBON ATOMS IN THE ALKYL RADICAL
  申请人：Lipowsky Gunter

  公开号：US20090023947A1

  公开（公告）日：2009-01-22

  A process for preparing tertiary alkyl esters of (meth)acrylic acid having at least 4 carbon atoms in the alkyl radical, comprising the steps of: (1) reacting (meth)acrylic acid with at least one olefin of the general formula I: in which R 1 and R 2 are an alkyl radical, and R 3 is a hydrogen atom, an alkyl radical, a cycloalkyl radical, an aryl radical, an alkylcycloalkyl radical, an alkylaryl radical, a cycloalkylaryl radical, or an alkylcycloalkylaryl radical; in homogeneous phase in the presence of an acidic catalyst in a reactor, (2) discharging the resulting reaction mixture (1) from the reactor, (3) separating the discharged reaction mixture (2) into a mixture (3.1) which comprises the catalyst and a mixture (3.2) which comprises the tertiary alkyl ester of (meth)acrylic acid having at least 4 carbon atoms in the alkyl radical, and (4) removing the tertiary alkyl ester of (meth)acrylic acid having at least 4 carbon atoms in the alkyl radical from the mixture (3.2), wherein, (5) in process step (4), at least one compound S which comprises at least one N-oxyl group is added as a stabilizer.

  一种制备具有至少4个碳原子的烷基基团的(甲基)丙烯酸的三级烷基酯的方法，包括以下步骤：(1) 在反应器中，在酸性催化剂的存在下，将(甲基)丙烯酸与至少一种具有通式I的烯烃反应：其中R1和R2为烷基基团，R3为氢原子、烷基基团、环烷基基团、芳基、烷基环烷基基团、烷基芳基基团、环烷基芳基基团或烷基环烷基芳基基团；(2) 从反应器中排出得到的反应混合物(1)；(3) 将排出的反应混合物(2)分离为包含催化剂的混合物(3.1)和包含至少4个碳原子的烷基基团的(甲基)丙烯酸的三级烷基酯的混合物(3.2)；(4) 从混合物(3.2)中去除至少4个碳原子的烷基基团的(甲基)丙烯酸的三级烷基酯；其中，在步骤(4)中，至少添加一种包含至少一个N-氧基团的化合物S作为稳定剂。
• Coating Composition, Optical Film, Antireflective, Film, Polarizing Plate, And Display Device Using The Same
  申请人：Yoshizawa Masataka

  公开号：US20080038561A1

  公开（公告）日：2008-02-14

  There is provided a coating composition capable of improving evenness in drying and evenness in airing and causing no impairment of evenness in coating, which is useful for an antireflective film having high uniformity in surface conditions and attaining sufficient antireflection performance and for a polarizing plate and a display device each using such an antireflective film. As the coating composition as mentioned above, a coating composition including a fluoroaliphatic group-containing copolymer that includes a repeating unit corresponding to the fluoroaliphatic group-containing monomer represented by the following formula (1) and a repeating unit corresponding to the monomer represented by the following formula (2) was found: in formula [1], R 0 represents a hydrogen atom, a halogen atom or a methyl group; L represents a divalent linkage group; and n represents an integer of 1 to 18, and in formula [2], R 11 represents a hydrogen atom, a halogen atom or a methyl group; L 11 represents a divalent linkage group; and R 13 , R 14 and R 15 each represents a 1-20C linear, branched or cyclic alkyl group which may have a substituent.

  提供了一种涂层组合物，能够提高干燥均匀性和通风均匀性，且不会影响涂层均匀性，该组合物对于具有高表面条件均匀性和达到足够抗反射性能的抗反射膜以及使用此类抗反射膜的偏光板和显示装置非常有用。作为上述涂层组合物，发现包括重复单元对应于以下公式（1）所表示的含氟脂肪基单体的含氟脂肪基共聚物和对应于以下公式（2）所表示的单体的重复单元的涂层组合物：在公式[1]中，R0表示氢原子、卤素原子或甲基基团；L表示双价连接基团；n表示1到18的整数，在公式[2]中，R11表示氢原子、卤素原子或甲基基团；L11表示双价连接基团；R13、R14和R15分别表示1-20C线性、支链或环状烷基，可以有取代基。
• Vitamin D derivatives
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US07985744B2

  公开（公告）日：2011-07-26

  The object of the present invention is to provide vitamin D derivatives that have excellent physiological activities as medicines, particularly as therapeutic agents for skin diseases such as psoriasis, and that have a reduced hypercalcemic effect. The present invention provides a vitamin D derivative of Formula (1): wherein X represents an oxygen atom or a sulfur atom; m represents a number of 1 to 3; R1 and R2 each represent a hydrogen atom or an alkyl group; R4 and R5 each represent a hydrogen atom or a hydroxyl group, etc.; R3 represents —YR8, etc.; R6 represents a hydrogen atom, etc.; R7 represents a hydrogen atom, etc.

  本发明的目的是提供具有出色生理活性的维生素D衍生物作为药物，特别是作为治疗银屑病等皮肤疾病的治疗剂，并具有减少高钙血症作用。本发明提供了一种式为（1）的维生素D衍生物：其中X表示氧原子或硫原子；m表示1到3的数字；R1和R2分别表示氢原子或烷基；R4和R5分别表示氢原子或羟基等；R3表示-YR8等；R6表示氢原子等；R7表示氢原子等。
• VITAMIN D DERIVATIVES
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1295871A1

  公开（公告）日：2003-03-26

  The object of the present invention is to provide vitamin D derivatives that have excellent physiological activities as medicines, particularly as therapeutic agents for skin diseases such as psoriasis, and that have a reduced hypercalcemic effect. The present invention provides a vitamin D derivative of Formula (1):    wherein X represents an oxygen atom or a sulfur atom; m represents a number of 1 to 3; R1 and R2 each represent a hydrogen atom or an alkyl group; R4 and R5 each represent a hydrogen atom or a hydroxyl group, etc.; R3 represents -YR8, etc.; R6 represents a hydrogen atom, etc.; and R7 represents a hydrogen atom, etc.

  本发明的目的是提供具有优良生理活性的维生素 D 衍生物，作为药物，特别是作为皮肤病如牛皮癣的治疗药物，具有降低高钙血症的作用。 本发明提供了一种式（1）的维生素 D 衍生物： 其中 X 代表氧原子或硫原子； m 代表 1 至 3 的数字； R1 和 R2 各自代表氢原子或烷基； R4和R5各自代表氢原子或羟基等； R3 代表-YR8 等； R6 代表氢原子等；以及 R7 代表氢原子等。
• HIGH VISCOSITY INDEX COMB POLYMER VISCOSITY MODIFIERS AND METHODS OF MODIFYING LUBRICANT VISCOSITY USING SAME
  申请人：Infineum International Limited

  公开号：EP3839017A1

  公开（公告）日：2021-06-23

  A comb copolymer viscosity modifier may be made by polymerization comprising at least, or consisting essentially of, the following monomers: (a) a hydrogenated polybutadiene-based (alk)acrylate ester macromonomer (which repeat units may comprise from 7.0 wt% to 18 wt% of the repeat units of the comb copolymer viscosity modifier); (b) a C3-C8 alkyl (alk)acrylate ester monomer (which repeat units may comprise from 40 wt% to 71 wt% or from 45 wt% to 64 wt% of the repeat units of the comb copolymer viscosity modifier); and (c) a C12-C24 alkyl (alk)acrylate ester monomer, wherein repeat units based on the C12-C24 alkyl (alk)acrylate ester monomer comprise at least 21.0 wt% (and optionally up to 35.0 wt%) of repeat units of the comb copolymer viscosity modifier. Lubricant compositions comprising the comb copolymer viscosity modifier, as well as uses thereof and methods for modifying viscosity, are also contemplated herein.

  梳状共聚物粘指剂可通过聚合制成，至少或主要由以下单体组成：(a) 氢化聚丁二烯基（烷基）丙烯酸酯大单体（其重复单元可占梳状共聚物粘指剂重复单元的 7.0 wt% 至 18 wt%）；(b) C3-C8 烷基（烷基）丙烯酸酯单体（其重复单元可占梳状共聚物粘指剂重复单元的 7.(b) C3-C8 烷基(烷基)丙烯酸酯单体(其重复单元可占梳状共聚物粘指剂重复单元的 40% 至 71% 或 45% 至 64%)；(c) C12-C24 烷基(烷基)丙烯酸酯单体，其中基于 C12-C24 烷基(烷基)丙烯酸酯单体的重复单元占至少 21.0 wt%（可选最多 35.0 wt%）的组合共聚物粘指剂重复单元。本文还考虑了包含梳状共聚物粘指剂的润滑剂组合物及其用途和粘度调节方法。